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Histidine rich calcium binding protein

HRC
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: CAN, Triadin, V1a, HAD, Calsequestrin
Papers on HRC
Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
New
Kim et al., Kwangju, South Korea. In Mol Cells, Jan 2016
Among them, calsequestrin (CSQ) and histidine-rich Ca(2+) binding protein (HRC) are known to bind the charged luminal region of triadin (TRN) and thus directly or indirectly regulate ryanodine receptor 2 (RyR2) activity.
The Hexapeptide Repeated Segment LIAGY is a Hot Spot of Aggregation of the Pseudomonas syringae Ice Nucleation Protein.
New
Di Martino, Cergy-Pontoise, France. In Protein Pept Lett, Dec 2015
A total of 38 hot spots of aggregation were predicted in the INP sequence: 7 localized in the Nterminal domain, 2 in the C-terminal region, 28 in the highly repetitive central (HRC) region and 1 shared between the HRC and the Carboxyl-terminus regions of the protein.
A Slow-Release Substrate Stimulates Groundwater Microbial Communities for Long-Term in Situ Cr(VI) Reduction.
New
Zhou et al., Norman, United States. In Environ Sci Technol, Dec 2015
Previous work indicated that a one-time amendment of polylactate hydrogen-release compound (HRC) reduced groundwater Cr(VI) concentrations for >3.5 years at a contaminated aquifer; however, microbial communities responsible for Cr(VI) reduction are poorly understood.
Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
New
Györke et al., Columbus, United States. In Cardiovasc Res, Dec 2015
AIMS: Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart.
Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.
New
Tian et al., Wuhan, China. In Cancer Sci, Oct 2015
We have recently shown that the histidine-rich calcium binding protein (HRC) promotes the invasion and metastasis of hepatocellular carcinoma (HCC).
Manganese Catalyzed C-H Halogenation.
New
Impact
Groves et al., Princeton, United States. In Acc Chem Res, Jul 2015
Given the high reactivity and enzymatic-like selectively of metalloporphyrins, we envision that this new Heteroatom-Rebound Catalysis (HRC) strategy will find widespread application in the C-H functionalization arena and serve as an effective tool for forming new carbon-heteroatom bonds at otherwise inaccessible sites in target molecules.
The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1.
New
Tian et al., Wuhan, China. In Oncotarget, Apr 2015
The histidine-rich calcium binding protein (HRC) is a regulator of Ca2+-homeostasis.
A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity.
Colson et al., Gold Coast, Australia. In Genet Res (camb), 2014
This investigation examined whether a palatable high refined carbohydrate (HRC) diet with the potential to induce obesity was linked to modulation of serotonin and dopamine signalling within the hypothalamus of rats.
Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend.
Review
Kranias et al., Cincinnati, United States. In J Mol Cell Cardiol, 2014
In addition, the intra-luminal histidine-rich calcium binding protein (HRC) has been shown to interact with both SERCA2a and triadin.
Effect of antisense microRNA targeting survivin on rectal cancer HRC-9698 cells and its mechanism.
Li et al., Changsha, China. In Int J Clin Exp Pathol, 2014
METHODS: Cultivate human rectal cancer HRC-9698 cells.
Overview of fundamental study of pazopanib in cancer.
Review
Zhou et al., Tianjin, China. In Thorac Cancer, 2014
It inhibited the proliferation of cell lines, such as DU-145 and HRC-45 in hepatocellular carcinoma, through mechanisms like "cell cycle arrest."
The arrhythmogenic human HRC point mutation S96A leads to spontaneous Ca(2+) release due to an impaired ability to buffer store Ca(2+).
Jones et al., Dunedin, New Zealand. In J Mol Cell Cardiol, 2014
The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been linked to cardiac arrhythmias in idiopathic dilated cardiomyopathy patients, potentially attributable to an increase in spontaneous Ca(2+) release events.
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
Review
Kranias et al., Athens, Greece. In J Mol Cell Cardiol, 2011
The histidine-rich calcium binding protein (HRC) is a novel regulator of sarcoplasmic reticulum (SR) Ca(2+)-uptake, storage and release.
Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis.
Review
O'Shea et al., Charlottesville, United States. In Clin Perinatol, 2010
A new tool, continuous monitoring of heart rate characteristics (HRC), is now available for clinical use.
Factors controlling the activity of the SERCA2a pump in the normal and failing heart.
Review
Vangheluwe et al., Leuven, Belgium. In Biofactors, 2009
Finally, we address the controversies and unanswered questions of other putative regulators of the cardiac Ca(2+) pump, such as sarcalumenin, HRC, S100A1, Bcl-2, HAX-1, calreticulin, calnexin, ERp57, IRS-1, and -2.
The Ser96Ala variant in histidine-rich calcium-binding protein is associated with life-threatening ventricular arrhythmias in idiopathic dilated cardiomyopathy.
GeneRIF
Kranias et al., Athens, Greece. In Eur Heart J, 2008
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.
GeneRIF
Kranias et al., Athens, Greece. In Am J Physiol Heart Circ Physiol, 2007
Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 and triadin, mediating a fine cross talk between SR Ca uptake and release in the heart.
Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein.
GeneRIF
Black et al., San Francisco, United States. In Mol Cell Biol, 2006
The exaggerated response of HRC knockout mice to the induction of cardiac hypertrophy is consistent with a regulatory role for HRC in calcium handling in vivo.
Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function.
GeneRIF
Kranias et al., Cincinnati, United States. In J Mol Cell Cardiol, 2006
HRC may be an integral regulatory protein involved in cardiac muscle SR Ca uptake and Ca homeostasis
Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein.
GeneRIF
Cho et al., Kwangju, South Korea. In Biochim Biophys Acta, 2005
Structure and expression of the mammalian HRC gene, together with the comparative expression data of the related sarcoplasmic reticulum genes.
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