Does oxidative stress modulate limb muscle atrophy in severe COPD patients?
Barcelona, Spain. In Eur Respir J, 2012
Compared with controls, in the quadriceps of muscle-wasted COPD patients, levels of protein carbonylation, oxidation of MyHC and myonuclei, superoxide anion production, superoxide dismutase, total protein ubiquinitation, E2(14k), atrogin-1, FoxO1 and p65 were higher, while content of MyHC, creatine kinase, carbonic anhydrase-3, myogenin, and fast-twitch fibre size were decreased.
Meiotic functions of RAD18.
Rotterdam, Netherlands. In J Cell Sci, 2011
At the XY body, RAD18 mediates the chromatin association of its interaction partners, the ubiquitin-conjugating enzymes HR6A and HR6B.
Biochemical mechanisms of cellular catabolism.
Birmingham, United Kingdom. In Curr Opin Clin Nutr Metab Care, 2002
Glucocorticoids have been suggested to activate this system in sepsis, while in cancer cachexia a tumour-produced sulphated glycoprotein, proteolysis-inducing factor, induces protein catabolism in skeletal muscle by increasing expression of proteasome subunits and the ubiquitin carrier protein, E2(14k).
Specific aspects of the ubiquitin system in spermatogenesis.
Rotterdam, Netherlands. In J Endocrinol Invest, 2000
In spermatogenesis, there appears to be a special requirement for certain components of the ubiquitin system, as exemplified in human and mouse by mutation of USP9Y and HR6B, respectively.