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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin-conjugating enzyme E2B, RAD6 homology

HR6B, E2(14k), ubiquitin-conjugating enzyme E2(14k)
may be involved in protein catabolism in response to fasting [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Ubiquitin, Ubiquitin-Protein Ligase, Histone, UBR1, ACID
Papers using HR6B antibodies
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Kirkpatrick David T., In PLoS ONE, 2002
... Hr6b genes were amplified using primer sets (Table S2) from cDNA and sub-cloned into pGADT7 and pGBKT7 plasmids (Clontech).
Papers on HR6B
Does oxidative stress modulate limb muscle atrophy in severe COPD patients?
Barreiro et al., Barcelona, Spain. In Eur Respir J, 2012
Compared with controls, in the quadriceps of muscle-wasted COPD patients, levels of protein carbonylation, oxidation of MyHC and myonuclei, superoxide anion production, superoxide dismutase, total protein ubiquinitation, E2(14k), atrogin-1, FoxO1 and p65 were higher, while content of MyHC, creatine kinase, carbonic anhydrase-3, myogenin, and fast-twitch fibre size were decreased.
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
Kwon et al., Pittsburgh, United States. In Plos One, 2011
UBR2 functions as a scaffold E3 that promotes HR6B/UbcH2-dependent ubiquitylation of H2A and H2B but not H3 and H4, through a mechanism distinct from typical polyubiquitylation.
Meiotic functions of RAD18.
Baarends et al., Rotterdam, Netherlands. In J Cell Sci, 2011
At the XY body, RAD18 mediates the chromatin association of its interaction partners, the ubiquitin-conjugating enzymes HR6A and HR6B.
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
Kwon et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2010
UBR2 interacts with the ubiquitin conjugating enzyme HR6B and its substrate H2A and promotes the HR6B-H2A interaction and the HR6B-to-H2A transfer of ubiquitin.
The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids.
Baarends et al., Rotterdam, Netherlands. In Bmc Genomics, 2009
HR6B represses major satellite repeat transcription in spermatocytes, and functions in the maintenance of X chromosome silencing in spermatocytes and spermatids.
Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.
Kwon et al., Pittsburgh, United States. In J Biol Chem, 2007
We show that HR6A and HR6B, the E2 enzymes that bind to UBR1 and UBR2, also interact with UBR3.
Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome.
Grootegoed et al., Rotterdam, Netherlands. In J Cell Sci, 2007
HR6B exerts control over different histone modifications in spermatocytes and spermatids, and that this function contributes to the postmeiotic maintenance of X chromosome silencing.
Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.
Scherthan et al., Berlin, Germany. In Exp Cell Res, 2006
The generally low frequencies of mid-preleptotene spermatocytes were significantly increased in male mice lacking recombination proteins SPO11, MEI1, MLH1, KU80, ubiquitin conjugating enzyme HR6B, and in mice with only one copy of the telomere length regulator Terf1.
Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway.
Tisdale et al., Birmingham, United Kingdom. In Life Sci, 2006
TPA induced an increased expression and activity of the ubiquitin-proteasome pathway, as evidenced by an increased functional activity, and increased expression of the 20S proteasome alpha-subunits, the 19S subunits MSS1 and p42, as well as the ubiquitin conjugating enzyme E2(14k), also with a maximal effect at a concentration of 25 nM and with a 3 h incubation time.
Ubiquitin-protein ligases in muscle wasting.
Lecker et al., Boston, United States. In Int J Biochem Cell Biol, 2005
Other experiments implicate E2(14k) and E3alpha, of the N-end rule pathway, as important players in the process.
The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth.
Klimaschewski et al., Innsbruck, Austria. In Mol Cell Neurosci, 2005
Therefore, N-end rule ubiquitination is required for neuronal differentiation of PC12 cells and may be involved in axonal regeneration of peripheral neurons.(HR6B enzyme, rat)
Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant.
Xu et al., Paris, France. In Mol Reprod Dev, 2003
Ube2b deficient mice are shown to present male infertility and sperm head shape anomalies.
Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways?
Lecker, Boston, United States. In Curr Opin Clin Nutr Metab Care, 2003
Other in-vitro studies also implicated E2(14k) and E3alpha, of the N-end rule pathway, as playing an important role in the process.
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Grootegoed et al., Rotterdam, Netherlands. In Mol Cell Biol, 2003
The present findings reveal a specific requirement for the ubiquitin-conjugating activity of HR6B in relation to dynamic aspects of the synaptonemal complex and meiotic recombination in spermatocytes.
Biochemical mechanisms of cellular catabolism.
Tisdale, Birmingham, United Kingdom. In Curr Opin Clin Nutr Metab Care, 2002
Glucocorticoids have been suggested to activate this system in sepsis, while in cancer cachexia a tumour-produced sulphated glycoprotein, proteolysis-inducing factor, induces protein catabolism in skeletal muscle by increasing expression of proteasome subunits and the ubiquitin carrier protein, E2(14k).
Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation.
Fischer et al., Cincinnati, United States. In Ann Surg, 2001
Released myofilaments are ubiquitinated in the N-end rule pathway, regulated by the ubiquitin-conjugating enzyme E2(14k) and the ubiquitin ligase E3 alpha, and degraded by the 26S proteasome.
Specific aspects of the ubiquitin system in spermatogenesis.
Grootegoed et al., Rotterdam, Netherlands. In J Endocrinol Invest, 2000
In spermatogenesis, there appears to be a special requirement for certain components of the ubiquitin system, as exemplified in human and mouse by mutation of USP9Y and HR6B, respectively.
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Hoeijmakers et al., Rotterdam, Netherlands. In Cell, 1996
The ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis.
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