[14-3-3/HIP-55 complex increases the stability of HIP-55].
Beijing, China. In Beijing Da Xue Xue Bao, Jan 2016
OBJECTIVE: To further demonstrate the interaction of a new 14-3-3 interaction protein hematopoietic progenitor kinase 1[HPK1]-interacting protein (HIP-55) and 14-3-3 proteins and its potential biological function in HEK293 cells.
The emerging roles of F-box proteins in pancreatic tumorigenesis.
Houston, United States. In Semin Cancer Biol, Oct 2015
We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.
[Interactions between MAP4K1 and adaptor proteins].
Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, Mar 2015
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1, also called hematopoietic progenitor kinase 1, HPK1) is a serine/threonine kinase.
Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.
College Park, United States. In Proc Natl Acad Sci U S A, 2014
Furthermore, BCR signaling is enhanced in Abp1(-/-) B cells compared with wild-type B cells, including Ca(2+) flux and phosphorylation of B-cell linker protein, the mitogen-activated protein kinase kinase MEK1/2, and ERK, coinciding with reductions in recruitment of the inhibitory signaling molecules hematopoietic progenitor kinase 1 and SH2-containing inositol 5-phosphatase to BCR signalosomes.
Phosphosite mapping of HIP-55 protein in mammalian cells.
Changchun, China. In Int J Mol Sci, 2013
In the present study, hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa (HIP-55) protein was over-expressed in HEK293 cells, which was genetically attached with 6x His tag.
HPK1 as a novel target for cancer immunotherapy.
New York City, United States. In Immunol Res, 2012
We have identified a hematopoietic cell-restricted serine/threonine kinase, hematopoietic progenitor kinase 1 (HPK1), as a possible target for therapeutic intervention.
Concepts of activated T cell death.
Heidelberg, Germany. In Crit Rev Oncol Hematol, 2008
Here, we discuss the regulation of AICD and ACAD in T cells and review the role of cytokines, T cell receptor (TCR) proximal signaling mediators like hematopoietic progenitor kinase 1 (HPK1) and the NF-kappaB pathway.
Life and death in peripheral T cells.
Heidelberg, Germany. In Nat Rev Immunol, 2007
Life and death of T cells is determined by multiple factors, such as T-cell receptor triggering, co-stimulation or cytokine signalling, and by molecules, such as caspase-8 (FLICE)-like inhibitory protein (FLIP) and haematopoietic progenitor kinase 1 (HPK1), which regulate the nuclear factor-kappaB (NF-kappaB) pathway.
Functional interactions of HPK1 with adaptor proteins.
Houston, United States. In J Cell Biochem, 2005
Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20-like kinase domain in its N-terminus, four proline-rich motifs, a caspase cleavage site, and a distal C-terminal Citron homology domain.