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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitogen-activated protein kinase kinase kinase kinase 1

HPK1, hematopoietic progenitor kinase 1
Top mentioned proteins: JNK, AP-1, PAK1, Src, V1a
Papers on HPK1
[14-3-3/HIP-55 complex increases the stability of HIP-55].
Li et al., Beijing, China. In Beijing Da Xue Xue Bao, Jan 2016
OBJECTIVE: To further demonstrate the interaction of a new 14-3-3 interaction protein hematopoietic progenitor kinase 1[HPK1]-interacting protein (HIP-55) and 14-3-3 proteins and its potential biological function in HEK293 cells.
The emerging roles of F-box proteins in pancreatic tumorigenesis.
Wang et al., Houston, United States. In Semin Cancer Biol, Oct 2015
We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.
[Interactions between MAP4K1 and adaptor proteins].
Zhang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, Mar 2015
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1, also called hematopoietic progenitor kinase 1, HPK1) is a serine/threonine kinase.
Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways.
Song et al., College Park, United States. In Proc Natl Acad Sci U S A, 2014
Furthermore, BCR signaling is enhanced in Abp1(-/-) B cells compared with wild-type B cells, including Ca(2+) flux and phosphorylation of B-cell linker protein, the mitogen-activated protein kinase kinase MEK1/2, and ERK, coinciding with reductions in recruitment of the inhibitory signaling molecules hematopoietic progenitor kinase 1 and SH2-containing inositol 5-phosphatase to BCR signalosomes.
Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs.
Fu et al., Atlanta, United States. In Oncotarget, 2014
HIP-55 (HPK1-interacting protein of 55 kDa, also named DBNL, SH3P7, and mAbp1) is a multidomain adaptor protein that is critical for organ development and the immune response.
Regulation of cell survival by the HIP-55 signaling network.
Li et al., Beijing, China. In Mol Biosyst, 2014
HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa) is the mammalian homologue of the yeast Abp1p.
The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.
Wang et al., In J Biol Chem, 2014
HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in >95% pancreatic cancer through proteasome-mediated degradation.
Phosphosite mapping of HIP-55 protein in mammalian cells.
Li et al., Changchun, China. In Int J Mol Sci, 2013
In the present study, hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa (HIP-55) protein was over-expressed in HEK293 cells, which was genetically attached with 6x His tag.
HPK1 as a novel target for cancer immunotherapy.
Burakoff et al., New York City, United States. In Immunol Res, 2012
We have identified a hematopoietic cell-restricted serine/threonine kinase, hematopoietic progenitor kinase 1 (HPK1), as a possible target for therapeutic intervention.
Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc.
Yang et al., Lexington, United States. In Biochim Biophys Acta, 2012
Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun.
The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.
Studzinski et al., Newark, United States. In Leuk Res, 2012
QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased.
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).
Tan et al., Houston, United States. In J Biol Chem, 2012
a novel negative feedback regulation of BCR signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK
Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.
Di Bartolo et al., Paris, France. In J Cell Biol, 2011
HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters.
Hematopoietic progenitor kinase 1, mitogen-activated protein/extracellular signal-related protein kinase kinase kinase 1, and phosphomitogen-activated protein kinase kinase 4 are overexpressed in extramammary Paget disease.
Furue et al., Fukuoka, Japan. In Am J Dermatopathol, 2011
The purpose of the study was to investigate the potential contribution of HPK1, MEKK1, TAK1, p-MKK4 to the development of extramammary Paget disease
Concepts of activated T cell death.
Arnold et al., Heidelberg, Germany. In Crit Rev Oncol Hematol, 2008
Here, we discuss the regulation of AICD and ACAD in T cells and review the role of cytokines, T cell receptor (TCR) proximal signaling mediators like hematopoietic progenitor kinase 1 (HPK1) and the NF-kappaB pathway.
Life and death in peripheral T cells.
Lavrik et al., Heidelberg, Germany. In Nat Rev Immunol, 2007
Life and death of T cells is determined by multiple factors, such as T-cell receptor triggering, co-stimulation or cytokine signalling, and by molecules, such as caspase-8 (FLICE)-like inhibitory protein (FLIP) and haematopoietic progenitor kinase 1 (HPK1), which regulate the nuclear factor-kappaB (NF-kappaB) pathway.
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.
Tan et al., Houston, United States. In Nat Immunol, 2007
HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling.
Functional interactions of HPK1 with adaptor proteins.
Tan et al., Houston, United States. In J Cell Biochem, 2005
Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a hematopoietic-specific mammalian STE20-like protein serine/threonine kinase, comprised of a STE20-like kinase domain in its N-terminus, four proline-rich motifs, a caspase cleavage site, and a distal C-terminal Citron homology domain.
Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.
Nussenzweig et al., New York City, United States. In Immunity, 2003
This pathway appears to be initiated by hematopoietic progenitor kinase-1 (HPK1), which interacts directly with Bam32, and differs from all previously characterized BCR signaling pathways in that it is required for normal BCR-mediated proliferation but not for B cell survival.
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.
Weiss et al., San Francisco, United States. In Immunity, 2000
The serine/threonine kinase HPK1 is a member of the germinal center kinase (GCK) family that has been implicated in the regulation of MAP kinase pathways.
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