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2-hydroxyacyl-CoA lyase 1

HPCL, 2-hydroxyphytanoyl-CoA lyase, HACL1, 2-HPCL
human homolog catalyzes alpha-oxidation and carbon-carbon cleavage of 3-methyl-branched fatty acids [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, fibrillin-1, STEP, OUT
Papers on HPCL
Sudden infant death syndrome and abnormal metabolism of thiamin.
New
Lonsdale, Cleveland, United States. In Med Hypotheses, Dec 2015
TPP is also a cofactor for the enzyme 2-hydroxyacyl-CoA lyase (HACL1) in the peroxisome, emphasizing its importance in alpha oxidation and plasmalogen synthesis in cell membrane physiology.
Enhancement of chondrocyte proliferation, distribution, and functions within polycaprolactone scaffolds by surface treatments.
New
Janvikul et al., Thailand. In J Biomed Mater Res A, Jul 2015
The hydrolysis of PCL was performed either before or after scaffold fabrication in the preparations of pre-hydrolyzed PCL (pre-HPCL) or post-HPCL scaffolds, respectively.
Thiamine and magnesium deficiencies: keys to disease.
New
Lonsdale, Cleveland, United States. In Med Hypotheses, Feb 2015
Because of the discovery of 2-hydroxyacyl-CoA lyase (HACL1) as the first peroxisomal enzyme in mammals found to be dependent on thiamine pyrophosphate (TPP) and the ability of thiamine to bind with prion protein, these factors should improve our clinical approach to TD. HACL1 has two important roles in alpha oxidation, the degradation of phytanic acid and shortening of 2-hydroxy long-chain fatty acids so that they can be degraded further by beta oxidation.
Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer.
Sun et al., Atlanta, United States. In Cancer Med, 2014
Gene expression profiling identified differential expression of a 5-gene panel (GLS, UBEC2, HACL1, MSI2, and LOC100129585) in cell lines with relatively greater sensitivity to platinum and veliparib combination.
RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1.
Van Veldhoven et al., Leuven, Belgium. In J Lipid Res, 2014
The enzymes involved in the aldehyde-generating steps of these processes are 2-hydroxyacyl-CoA lyase (HACL1) and sphingosine-1-phosphate lyase (SGPL1), respectively.
Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: in vitro and in vivo evaluation.
Rui et al., Nanjing, China. In Int J Pharm, 2013
It was found that the formulation presented a well zero-order behavior at the weight ratio of drug 11:14 (core:layer) and the combination of HPC-L (8.0 mPa s) and HPC-M (350 mPa s) (8:9), with the "f2" of 66.90.
Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase.
GeneRIF
Van Veldhoven et al., Leuven, Belgium. In Biochim Biophys Acta, 2011
Transport of thiamine pyrophosphate into peroxisomes is dependent on HACL1 import, without requirement of a specific solute transporter.
A new crystal form of mouse thiamin pyrophosphokinase.
Hurley et al., Indianapolis, United States. In Int J Biochem Mol Biol, 2010
TPP is the cofactor of metabolically important enzymes such as pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, branched-chain α-keto acid dehydrogenase, transketolase and 2-hydroxyphytanoyl-CoA lyase.
[A preliminary study on screening for Porphyromonas gingivalis outer membrane protein antigen with two-dimensional liquid phase fractionation and matrix-assisted laser desorption ionization time-of-flight/time-of-flight mass spectrometry].
Gou et al., Xi'an, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2010
B7 fractions of 3 strains of Pg were separated by the reversed-phase high performance liquid chromatography (RP-HPCL) separation process.
[Effect of doxorubicin induced GM-CSF gene expression regulated by Egr-1 promoter on recovery of hematopoietic function in bearing-melanoma mice].
Hao et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009
The experimental mice were randomly divided into 4 groups (6 mice in each group): (1) HFCL/EG + ADM group in which the HFCL/EG cells were transplanted intravenously in SCID mice bearing melanoma, ADM was given intraperitoneally after 3 days; (2) HFCL + ADM group in which the HFCL cells were transplanted intravenously, ADM was given intraperitoneally after 3 days; (3) HPCL/EG group in which HFCL/EG cells were transplanted alone; (4) HFCL group in which HFCL cells were transplanted alone.
Histaminergic activity in a rodent model of Parkinson's disease.
Brus et al., Zabrze, Poland. In Neurotox Res, 2009
At 8 weeks levels of DA and its metabolites L: -3,4-dihydroxyphenylalanine (DOPAC) and homovanillic acid (HVA) were estimated in the striatum and frontal cortex by HPCL/ED technique.
The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids.
Review
Van Veldhoven et al., Leuven, Belgium. In Biochem Soc Trans, 2007
2-Hydroxyphytanoyl-CoA lyase (abbreviated as 2-HPCL), renamed to 2-hydroxyacyl-CoA lyase (abbreviated as HACL1), is the first peroxisomal enzyme in mammals that has been found to be dependent on TPP (thiamin pyrophosphate).
Presence of thiamine pyrophosphate in mammalian peroxisomes.
Van Veldhoven et al., Leuven, Belgium. In Bmc Biochem, 2006
BACKGROUND: Thiamine pyrophosphate (TPP) is a cofactor for 2-hydroxyacyl-CoA lyase 1 (HACL1), a peroxisomal enzyme essential for the alpha-oxidation of phytanic acid and 2-hydroxy straight chain fatty acids.
Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids.
GeneRIF
Casteels et al., Leuven, Belgium. In J Biol Chem, 2005
2-hydroxyphytanoyl-CoA lyase has a role in the breakdown of long chain 2-hydroxyfatty acids
Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation.
Review
Gibberd et al., London, United Kingdom. In J Neurochem, 2002
The transport and biochemical pathways of phytanic acid metabolism have recently been defined with the cloning of two key enzymes, phytanoyl-CoA 2-hydroxylase (PAHX) and 2-hydroxyphytanoyl-CoA lyase, together with the confirmation of their localization in peroxisomes.
Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids.
GeneRIF
Casteels et al., Leuven, Belgium. In Proc Natl Acad Sci U S A, 1999
peroxisomal thiamine-pyrophosphate depending enzyme required for the degradation of phytanic acid, catalyzing the cleavage of 2-hydroxyphytanoyl-CoA lyase into formyl-CoA and pristanal
Radioimmune, radiobinding and HPLC analysis of 2-5A and related oligonucleotides from intact cells.
Impact
Kerr et al., In Nature, 1980
In combination with more satisfactory high performance liquid chromatography (HPCL) methods using reverse-phase C18 columns, these assays have been used to detect core and 2-5A in crude extracts from interferon-treated cells.
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