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Chromobox homolog 1

HP1beta, Mod-1, CBX1, M-31
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Haptoglobin, Histone, HP1gamma, CAN, ACID
Papers using HP1beta antibodies
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays.
Supplier
Defossez Pierre-Antoine, In PLoS ONE, 1998
... The Cbx1 expression construct was derived by PCR from mouse cDNA, cloned into pEGFP-C1 (Clontech, USA) and verified by ...
Papers on HP1beta
Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.
New
Jäättelä et al., Copenhagen, Denmark. In Nucleic Acids Res, Jan 2016
Accordingly, HDGFRP2 is found in complex with the heterochromatin-binding chromobox homologue 1 (CBX1) and Pogo transposable element with ZNF domain (POGZ).
Bacillus licheniformis Isolated from Traditional Korean Food Resources Enhances the Longevity of Caenorhabditis elegans through Serotonin Signaling.
New
Kim et al., Chŏnju, South Korea. In J Agric Food Chem, Jan 2016
In addition, qRT-PCR and an aging assay with mutant worms showed that the conditioning of B. licheniformis strain 141 directly influenced genes associated with serotonin signaling in nematodes, including tph-1 (tryptophan hydroxylase), bas-1 (serotonin- and dopamine-synthetic aromatic amino acid decarboxylase), mod-1 (serotonin-gated chloride channel), ser-1, and ser-7 (serotonin receptors) during C. elegans aging.
Sensory and physicochemical evaluation of low-fat chicken mortadella with added native and modified starches.
New
Demiate et al., Santa Maria, Brazil. In J Food Sci Technol, Jul 2015
Two formulations containing native cassava and regular corn starch, coded CASS (5.0 % of cassava starch) and CORN (5.0 % of regular corn starch), and one formulation produced with physically treated starch coded as MOD1 (2.5 % of Novation 2300) and chemically modified starch coded as MOD2 (2.5 % of Thermtex) were studied.
A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects.
New
Fundele et al., Uppsala, Sweden. In J Biosci, Jun 2015
Mammals have three HP1 protein isotypes HP1 beta (CBX1), HP1 alpha (CBX3) and HP1 alpha (CBX5) that are encoded by the corresponding genes Cbx1, Cbx3 and Cbx5.
Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species.
New
Li et al., Beijing, China. In Cell Res, May 2015
Arabidopsis Mosaic Death 1 (MOD1), an enoyl-acyl carrier protein (ACP) reductase essential for fatty acid biosynthesis in chloroplasts, negatively regulates PCD in Arabidopsis.
Proteomic analysis of embryonic kidney development: Heterochromatin proteins as epigenetic regulators of nephrogenesis.
Dihazi et al., Göttingen, Germany. In Sci Rep, 2014
Bioinformatics analysis suggests developmental stage-specific pathway activation and highlighted heterochromatin protein 1 (Cbx1, Cbx3, Cbx5) and Trim28 as potential key players in nephrogenesis.
An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Impact
Srinivasan et al., Los Angeles, United States. In Cell Metab, 2013
We show that the serotonergic chloride channel MOD-1 relays a long-range endocrine signal from C. elegans body cavity neurons to control distal ATGL-1 function, via the nuclear receptor NHR-76.
Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.
Impact
Bargmann et al., New York City, United States. In Cell, 2013
Serotonin promotes dwelling states through the MOD-1 serotonin-gated chloride channel.
Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.
GeneRIF
Khanna et al., Brisbane, Australia. In J Biol Chem, 2012
a novel mechanism of KAP-1-mediated chromatin restructuring via Chk2-regulated HP1-beta exchange from heterochromatin, promoting DNA repair.
A heterochromatin protein 1 (HP1) dimer and a proliferating cell nuclear antigen (PCNA) protein interact in vivo and are parts of a multiprotein complex involved in DNA replication and DNA repair.
GeneRIF
Dobrucki et al., Kraków, Poland. In Cell Cycle, 2012
HP1 beta and PCNA, a key player in DNA replication, are closely spaced components of a multiprotein complex involved in replication, both in S phase and during DNA repair, and that the functional complex requires formation of an HP1 dimer.
Gastrin-releasing peptide signaling alters colon cancer invasiveness via heterochromatin protein 1Hsβ.
GeneRIF
Benya et al., Chicago, United States. In Am J Pathol, 2011
Abrogating GRP/GRPR signaling specifically down-regulates HP1(Hsbeta) expression and inhibiting GRPR signaling, or ablating HP1(Hsbeta) expression, increases colon cancer cell invasiveness in vitro.
HP1 proteins--what is the essential interaction?
Review
Singh, Germany. In Genetika, 2010
There are three mammalian HP1 genes, Cbx5 (encoding HP1alpha), Cbx1 (encoding HP1beta) and Cbx3 (encoding HP1gamma).
Human heterochromatin protein 1 isoform HP1beta enhances androgen receptor activity and is implicated in prostate cancer growth.
GeneRIF
Naito et al., Fukuoka, Japan. In Endocr Relat Cancer, 2010
HP1beta is involved in the proliferation of AR-expressing prostate cancer cells and progression to CRPC as an AR coactivator.
Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
GeneRIF
Parnaik et al., Hyderābād, India. In Plos One, 2009
Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity.
The emerging role of HP1 in the DNA damage response.
Review
Luijsterburg et al., Copenhagen, Denmark. In Mol Cell Biol, 2009
The loss of HP1 renders nematodes highly sensitive to DNA damage, and mice lacking HP1beta suffer from genomic instability, suggesting that the loss of HP1 is not necessarily beneficial for repair.
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Impact
Price et al., Boston, United States. In Nat Cell Biol, 2009
In addition, the ability of Tip60 to access H3K9me3 is dependent on the DNA damage-induced displacement of HP1beta (heterochromatin protein 1beta) from H3K9me3.
JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
Impact
Kouzarides et al., Cambridge, United Kingdom. In Nature, 2009
Heterochromatin protein 1alpha (HP1alpha), but not HP1beta, specifically binds to this region of H3 through its chromo-shadow domain.
Mobilization and recruitment of HP1: a bimodal response to DNA breakage.
Review
Venkitaraman et al., Cambridge, United Kingdom. In Cell Cycle, 2009
We have reported (Ayoub et al., Nature 2008; 453: 682-6) that the rapid mobilization of the heterochromatin protein, HP1beta, within seconds from DSB sites promotes chromatin changes like H2AX phosphorylation that trigger this response.
Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.
Review
Venkitaraman et al., Cambridge, United Kingdom. In Cell Cycle, 2009
Here, we briefly outline what is known about the chromatin changes that occur during the cellular response to DNA breakage, focusing on our recent findings revealing that the chromatin factor HP1beta is mobilized within seconds after DNA damage by an unrecognized signaling cascade mediated by casein kinase 2 (CK2) phosphorylation, paving the way for histone H2AX phosphorylation.
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.
Impact
GeneRIF
Venkitaraman et al., Cambridge, United Kingdom. In Nature, 2008
findings reveal an unrecognized signalling cascade that helps to initiate the DNA damage response, altering chromatin by modifying a histone-code mediator protein, HP1, but not the code itself
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