The emerging role of HP1 in the DNA damage response.
Copenhagen, Denmark. In Mol Cell Biol, 2009
The loss of HP1 renders nematodes highly sensitive to DNA damage, and mice lacking HP1beta suffer from genomic instability, suggesting that the loss of HP1 is not necessarily beneficial for repair.
Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.
Cambridge, United Kingdom. In Cell Cycle, 2009
Here, we briefly outline what is known about the chromatin changes that occur during the cellular response to DNA breakage, focusing on our recent findings revealing that the chromatin factor HP1beta is mobilized within seconds after DNA damage by an unrecognized signaling cascade mediated by casein kinase 2 (CK2) phosphorylation, paving the way for histone H2AX phosphorylation.