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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Homeobox D8

HOXD8, Hox-4.3
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] (from NCBI)
Papers on HOXD8
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Miyazono et al., Tokyo, Japan. In J Cell Sci, 2009
Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels.
Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds.
Lanning et al., Richmond, United States. In J Surg Res, 2008
Hoxd8 is increased in mid-gestational wounds compared with late-gestational control skin
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