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Homeobox D8

HOXD8, Hox-4.3
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: CAN, Hoxc8, HOXD1, Hoxd4, ACID
Papers on HOXD8
An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction.
Alfaidy et al., Melbourne, Australia. In Mol Med, Aug 2015
The Homeobox gene array identified a >5-fold increase in HOXA9, HOXC8, HOXC10, HOXD1, HOXD8, HOXD9 and HOXD11, while NKX 3.1 showed a >2 fold-decrease in mRNA expression compared to untreated controls.
DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations.
Achatz et al., São Paulo, Brazil. In Braz J Med Biol Res, Jul 2015
This study aimed to identify the DNA methylation pattern of genes potentially related to the TDG pathway (CDKN2A, FOXA1, HOXD8, OCT4, SOX2, and SOX17) in 30 patients with germline TP53 mutations, 10 patients with wild-type TP53, and 10 healthy individuals.
Transcriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheathing cells, and Schwann cell-like glia.
Baumgärtner et al., Hannover, Germany. In Glia, 2014
Differentially expressed genes possibly involved in the maintenance of cell type-specific identity included an up-regulation of HOXD8 and HOXC4 in SCs, and an up-regulation of CNTNAP2 and EFEMP1 in OECs/SG.
Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.
Gudas et al., New York City, United States. In J Cell Physiol, 2014
We detected the H3K9me3 mark at HOXB7, HOXC10, HOXC13, and HOXD8 at levels higher in OKF6-TERT1R than in SCC-9 cells; at IRX1 and SIX2 the H3K9me3 levels were conversely higher in SCC-9 than in OKF6-TERT1R.
Expression of the HOX genes and HOTAIR in atypical teratoid rhabdoid tumors and other pediatric brain tumors.
Bhardwaj et al., Westmead, Australia. In Cancer Genet, 2014
Results indicate that in ATRTs, medulloblastomas, and JPAs, the HOTAIR and HOXC genes are highly expressed; however, HOXD8-10 genes are not silenced.
Adult human neural crest-derived cells for articular cartilage repair.
Martin et al., Basel, Switzerland. In Sci Transl Med, 2014
Using hyaline cartilage as a model, we showed that adult human neuroectoderm-derived nasal chondrocytes (NCs) can be constitutively distinguished from mesoderm-derived articular chondrocytes (ACs) by lack of expression of specific HOX genes, including HOXC4 and HOXD8.
Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease.
Kanai et al., In Int J Cancer, 2014
DNA methylation levels of hallmark genes for each cluster, such as IRX2, HOXD8, SPARCL1, RGS5 and EI24, were again correlated with clinicopathological characteristics in the validation cohort.
Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.
Gudas et al., New York City, United States. In Exp Cell Res, 2014
HOXB7, HOXC10, HOXC13, and HOXD8 transcripts are higher in SCC-9 than in OKF6-TERT1R cells; using ChIP (chromatin immunoprecipitation) we detected PRC2 protein SUZ12 and the epigenetic H3K27me3 mark on histone H3 at these genes in OKF6-TERT1R, but not in SCC-9 cells.
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Morrell et al., Cambridge, United Kingdom. In Plos One, 2013
For example, this included a cluster on chromosome 2 of HOXD1, HOXD3, HOXD4, HOXD8 and HOXD9 that was expressed at a higher level in BOECs.
DNA methylation profiles of long- and short-term glioblastoma survivors.
Latif et al., Birmingham, United Kingdom. In Epigenetics, 2013
Our preliminary study also identified a set of CpG loci differentially hypermethylated between STS and LTS cases, including members of the homeobox gene family (HOXD8, HOXD13 and HOXC4), the transcription factors NR2F2 and TFAP2A, and Dickkopf 2, a negative regulator of the wnt/β-catenin signaling pathway.
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.
Ding et al., Augusta, United States. In Plos One, 2011
The HOXD cluster contains nine genes (HOXD1, HOXD3, HOXD4, and HOXD8-13) that are positioned sequentially from 3' to 5', with HOXD1 at the 3' end and HOXD13 the 5' end.
Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma.
Parekh et al., United States. In Blood, 2010
Using biologic and statistical criteria, we further identified 4 hypermethylated genes CDKN2B, MLF-1, PCDH8, and HOXD8 and 4 hypomethylated genes CD37, HDAC1, NOTCH1, and CDK5 when aberrant methylation was associated with inverse changes in mRNA levels.
The HOX Code as a "biological fingerprint" to distinguish functionally distinct stem cell populations derived from cord blood.
Kögler et al., Düsseldorf, Germany. In Stem Cell Res, 2010
Briefly, RT-PCR analysis of the HOX code revealed a high similarity between BM-MSC and CB-MSC, which are both HOX-positive, whereas USSC resembled H9 embryonic stem cells HOX-negative.Especially HOXA9, HOXB7, HOXC10 and HOXD8 are good candidate markers to discriminate MSC from USSC.
Regulation of H3K27me3 and H3K4me3 during early porcine embryonic development.
Hall et al., Copenhagen, Denmark. In Mol Reprod Dev, 2010
In addition, the expression of Hox genes, HOXA2, HOXA3, HOXA7, HOXA10, HOXB4, HOXB7, HOXC8, HOXD8, and HOXD10 was investigated.
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Miyazono et al., Tokyo, Japan. In J Cell Sci, 2009
Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels.
Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds.
Lanning et al., Richmond, United States. In J Surg Res, 2008
Hoxd8 is increased in mid-gestational wounds compared with late-gestational control skin
MicroRNA-directed cleavage of HOXB8 mRNA.
Bartel et al., Cambridge, United States. In Science, 2004
We find that miR-196, a miRNA encoded at three paralogous locations in the A, B, and C mammalian HOX clusters, has extensive, evolutionarily conserved complementarity to messages of HOXB8, HOXC8, and HOXD8.
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