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Homeobox D4

Hoxd4, Hox-4.2, HOX4B, Hox-5.1, hoxd4a
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HOXB4, HOXC6, HOXD8
Papers on Hoxd4
Characterization of HOX gene expression in canine mammary tumour cell lines from spontaneous tumours.
New
Curtis Bird et al., Auburn, United States. In Vet Comp Oncol, Sep 2015
Five canine HOX genes were overexpressed with expression profiles consistent with oncogene-like character (HOXA1, HOXA13, HOXD4, HOXD9 and SIX1) and three HOX genes with underexpressed profiles (HOXA11, HOXC8 and HOXC9) were also identified as was an apparent nonsense mutation in HOXC6.
Over-expression of miR-10b in NPC patients: correlation with LMP1 and Twist1.
New
Ayadi et al., Sfax, Tunisia. In Tumour Biol, May 2015
Then, we investigated the correlation between miR-10b expression and its upstream regulators LMP1/Twist1 as well as its adjacent gene HoxD4.
Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.
Ikegawa et al., Tokyo, Japan. In Plos One, 2014
To identify the causal gene of sporadic SEDAC, we performed whole exome sequencing for 12 subjects with sporadic SEDAC and identified heterozygous HOXD4 loss-of-function mutations in three subjects.
A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.
Puzyrev et al., Tomsk, Russia. In Plos One, 2014
Four CpG-sites located within the MIR10B gene sequence and about 1 kb upstream of the HOXD4 gene were also confirmed as hypomethylated in the independent dataset of the right coronary arteries in the area of advanced atherosclerotic plaques in comparison with the other vascular tissues.
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Morrell et al., Cambridge, United Kingdom. In Plos One, 2013
For example, this included a cluster on chromosome 2 of HOXD1, HOXD3, HOXD4, HOXD8 and HOXD9 that was expressed at a higher level in BOECs.
Copy number variants in short children born small for gestational age.
Ruivenkamp et al., Leiden, Netherlands. In Horm Res Paediatr, 2013
Bioinformatic analysis of the de novo and segregating CNVs suggested that HOXD4, AGPS, PDE11A, OSBPL6, PRKRA and PLEKHA3, and possibly DGKB and TNFRSF11B are potential candidate genes.
[DNA methylation profiling of the vascular tissues in the setting of atherosclerosis].
Puzyrev et al., In Mol Biol (mosk), 2013
The most pronounced differences in the methylation level were registered for CpG-sites of homeobox genes HOXA2 and HOXD4 as well as imprinted gene MEST.
Salamander Hox clusters contain repetitive DNA and expanded non-coding regions: a typical Hox structure for non-mammalian tetrapod vertebrates?
Tsonis et al., Lexington, United States. In Hum Genomics, 2012
In particular, the distance between hoxd13 and hoxd11 is longer in newt than orthologous regions from vertebrate species with expanded Hox clusters and is predicted to exceed the length of the entire HoxD clusters (hoxd13-hoxd4) of humans, mice, and frogs.
Zebrafish hoxd4a acts upstream of meis1.1 to direct vasculogenesis, angiogenesis and hematopoiesis.
Featherstone et al., Singapore, Singapore. In Plos One, 2012
Mice lacking the 4th-group paralog Hoxd4 display malformations of the anterior vertebral column, but are viable and fertile.
Genome-wide aberrant DNA methylation of microRNA host genes in hepatocellular carcinoma.
Santella et al., New York City, United States. In Epigenetics, 2012
Among the 54 significant CpG sites, 15 sites had more than 2-fold tumor/non-tumor changes, 17 sites had differences > 10%, and 10 sites had both features [including 8 significantly hypermethylated CpG sites in the host genes of miR-10a, miR-10b and miR-196b (HOXB4, HOXD4 and HOXA9, respectively)].
Methylation alterations of WT1 and homeobox genes in inflamed muscle biopsy samples from patients with untreated juvenile dermatomyositis suggest self-renewal capacity.
Pachman et al., Chicago, United States. In Arthritis Rheum, 2012
Six homeobox genes were among them; ALX4, HOXC11, HOXD3, and HOXD4 were hypomethylated, while EMX2 and HOXB1 were hypermethylated.
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.
Ding et al., Augusta, United States. In Plos One, 2011
The HOXD cluster contains nine genes (HOXD1, HOXD3, HOXD4, and HOXD8-13) that are positioned sequentially from 3' to 5', with HOXD1 at the 3' end and HOXD13 the 5' end.
Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and HOXD4.
GeneRIF
Featherstone et al., Singapore, Singapore. In Plos One, 2010
The expression profiles of Hoxd4 and miR-10b transcripts during neural differentiation of mouse embryonal carcinoma (EC) P19 cells are co-ordinately regulated and generated by Drosha cleavage.
Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.
GeneRIF
Zhang et al., Shanghai, China. In Acta Pharmacol Sin, 2010
The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women
Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice.
GeneRIF
Kappen et al., Omaha, United States. In Plos One, 2009
Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4-transgenic mice.
Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells.
GeneRIF
Chen et al., Beijing, China. In Bmc Mol Biol, 2008
microRNA-10a (miR-10a) targets a homologous DNA region in the promoter region of the hoxd4 gene and represses its expression at the transcriptional level
Enhancer detection in zebrafish permits the identification of neuronal subtypes that express Hox4 paralogs.
GeneRIF
Rinkwitz et al., Oldenburg, Germany. In Dev Dyn, 2008
hoxb4a in combination with its paralogs hoxa4a and hoxd4a may play a significant role in the development of precerebellar, vagal, and pectoral fin neuronal subtypes
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene.
Impact
Chambon et al., Strasbourg, France. In Nature, 1992
To test this model further, we have expressed the Hox-4.2
A human HOX4B regulatory element provides head-specific expression in Drosophila embryos.
Impact
McGinnis et al., New Haven, United States. In Nature, 1992
Like other homeobox genes of the Antennapedia and bithorax complexes (collectively called the HOM complex), the Drosophila Deformed (Dfd) gene has structural homologues in the Hox/HOX complexes of mouse and humans, one of which is human HOX4B (refs 3, 4).
Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae.
Impact
McGinnis et al., New Haven, United States. In Cell, 1990
A fusion gene consisting of a heat shock promoter attached to the human Hox-4.2
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