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Homeobox D12

Hoxd12, Hox-4.7
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Hoxd11, SP-D, ACID, Shh, HOX11
Papers on Hoxd12
Systematic analysis of gene expression pattern in has-miR-197 over-expressed human uterine leiomyoma cells.
Xu et al., Jiangyin, China. In Biomed Pharmacother, Oct 2015
The qRT-PCR results confirmed that 17 of the 66 selected genes, which were up- or down-regulated more than 10-fold by miR-197, were consistent with the microarray results, including tumorigenesis-related genes, such as DRT7, SLC549, SFMBT2, FLJ37956, FBLN2, C10orf35, HOXD12, CACNG7, and LOC100134279.
Gene microarray analysis of the lncRNA expression profile in human urothelial carcinoma of the bladder.
Wu et al., Shanghai, China. In Int J Clin Exp Med, 2013
nc-HOXA11-86, nc-HOXD10-7, nc-HOXB9-205, CES4, nc-HOXD12-3, systematic research on these lncRNAs will help clarify the mechanisms of urothelial carcinoma of the bladder and guide the early diagnosis and treatment of this cancer in the future.
Anorectal atresia and variants at predicted regulatory sites in candidate genes.
Mills et al., Bethesda, United States. In Ann Hum Genet, 2013
Variants predicted to affect transcription factor binding, splicing, and DNA methylation in WNT3A, PCSK5, TCF4, MKKS, GLI2, HOXD12, and BMP4 were associated with anorectal atresia based on a nominal P value < 0.05.
Spatio-temporal expression of HOX genes in human hindgut development.
Schwarzer et al., Innsbruck, Austria. In Dev Dyn, 2013
RESULTS: Applying in situ hybridization and immunohistochemistry, we observed expression of HOXA11, HOXA13, HOXD12, and HOXD13 in developmental week 6.
Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.
Ding et al., Augusta, United States. In Plos One, 2011
Individual induction of HOXD8, HOXD9, HOXD10 or HOXD12 is sufficient to induce both growth arrest and neuronal differentiation, which is associated with downregulation of cell cycle-promoting genes and upregulation of neuronal differentiation genes.
Duplication at chromosome 2q31.1-q31.2 in a family presenting syndactyly and nystagmus.
Holder-Espinasse et al., Lille, France. In Eur J Hum Genet, 2011
We performed expression studies in lymphoblasts by reverse transcription-PCR and observed an HOXD13 and HOXD10 overexpression, whereas the HOXD12 expression was decreased.
Study of HOXD genes in autism particularly regarding the ratio of second to fourth digit length.
Osawa et al., Hamamatsu, Japan. In Brain Dev, 2010
data show no significant difference in HOXD11, HOXD12 & HOXD13 genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD
A region of the human HOXD cluster that confers polycomb-group responsiveness.
Kingston et al., Boston, United States. In Cell, 2010
In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate.
Breaking the seals: efficient mRNA detection from human archival paraffin-embedded tissue.
Schwarzer et al., Innsbruck, Austria. In Rna, 2009
During our study on HOXA13, HOXD12, and HOXD13 mRNA expression in human adult and embryonic tissues, we were confronted with the fact that, within our specimen collection, as in other University Departments in Europe, <20% of all samples yielded reliable labeling, while most samples were resistant to hybridization by standard protocols due to over-fixation.
Point mutation of Hoxd12 in mice.
Jung et al., Seoul, South Korea. In Yonsei Med J, 2009
point mutation rather than the entire deletion of Hoxd12, such as in knockout and transgenic mice, causes the abnormal limb phenotype in microdactyly mice
Characterization of Xenopus digits and regenerated limbs of the froglet.
Ide et al., Sendai, Japan. In Dev Dyn, 2006
The anteriormost digit is characterized by being hoxd13-positive and hoxd12 (hoxd11)-negative in the chick and mouse.
Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas.
Ushijima et al., Tokyo, Japan. In Cancer Res, 2006
CGIs in putative promoter regions of 34 genes (ABHD9, BARHL1, CLIC5, CNNM1, COL2A1, CPT1C, DDIT4L, DERL3, DHRS3, DPYS, EFEMP2, FAM62C, FAM78A, FLJ33790, GBX2, GPR10, GPRASP1, HOXA9, HOXD11, HOXD12, HOXD13, p14ARF, PAX6, PRDX2, PTPRG, RASD1, RAX, REC8L1, SLC27A3, TGFB2, TLX2, TMEM22, TMEM30B, and UNC5C) were found to be methylated in at least 1 of 13 melanoma cell lines but not in two cultured normal melanocytes.
[Analysis of association between 5' HOXD gene and idiopathic congenital talipes equinovarus].
Sun et al., Shenyang, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2005
Data show that HOXD12 are important susceptible genes of idiopathic congenital talipes equinovarus.
Aberrant expression of HOX genes in human invasive breast carcinoma.
Moriuchi et al., Sapporo, Japan. In Oncol Rep, 2005
Comparing expression levels of each HOX gene among the different types of cancer tissues, the expression level of HOXB7 was lower in lymph node metastasis-positive cancer tissues than negative cancer tissues; those of HOXD12 and D13 were higher in progesterone receptor-positive cancer tissues than negative cancer tissues; and the expression level of HOXC5 was lower in cancerous tissues with mutated-type p53 than in normal and cancerous tissues with wild-type p53.
A dual role for Hox genes in limb anterior-posterior asymmetry.
Duboule et al., Genève, Switzerland. In Science, 2004
early posterior restriction of Hox gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh; this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes
A pair of sibs with tibial hemimelia born to phenotypically normal parents.
Ikegawa et al., Tokyo, Japan. In J Hum Genet, 2002
Screening of mutation by direct sequencing of candidate genes including Sonic hedgehog, HOXD-11, and HOXD-12 was unable to identify a disease-causing mutation.
Retinoic acid is essential for Shh/Hoxd signaling during rat limb outgrowth but not for limb initiation.
Smith et al., Madison, United States. In Dev Dyn, 1999
Molecular analysis of RA-deficient limb buds revealed enhanced gli-3 and reduced hoxd-12, hoxd-13, shh, and fgf-4, while fgf-8, en-1, and wnt-7a expression remained unaltered.
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