Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice.
Palma, Spain. In J Cell Physiol, Feb 2016
Primary white Rb(+/-) adipocytes displayed under basal conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b), but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2).
A stringent validation of mouse adipose tissue identity markers.
Stockholm, Sweden. In Am J Physiol Endocrinol Metab, Jul 2015
Most of these markers unexpectedly turned out to be noninformative concerning tissue classification (Car4, Cited1, Ebf3, Eva1, Fbxo31, Fgf21, Lhx8, Hoxc8, and Hoxc9).
Direct evidence of brown adipocytes in different fat depots in children.
Leipzig, Germany. In Plos One, 2014
Samples with brown-like adipocytes showed an increased expression of UCP1 (>200fold), PRDM16 (2.8fold), PGC1α and CIDEA while other brown/beige selective markers, such as PAT2, P2RX5, ZIC1, LHX8, TMEM26, HOXC9 and TBX1 were not significantly different between UCP1 positive and negative samples.
Evolving locomotion with Hoxc9.
Portugal. In Dev Cell, 2014
(2014) show that Hoxc9 restriction of Foxp1, high levels of which specify limb-innervating motor neurons, first appeared in vertebrates concomitantly with paired appendages.