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Homeobox C9

Hoxc9, Hox-3.2
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Hoxc8, Antennapedia, CAN, Hoxa5, SET
Papers on Hoxc9
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice.
New
Ribot et al., Palma, Spain. In J Cell Physiol, Feb 2016
Primary white Rb(+/-) adipocytes displayed under basal conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b), but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2).
Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits.
New
Klöting et al., Leipzig, Germany. In Obesity (silver Spring), Jan 2016
Here, the hypothesis that human adipose tissue (AT) expression of the developmental genes homeobox transcription factors C9 (HOXC9) and C10 (HOXC10) is fat depot-specific and related to obesity-related traits was tested.
Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1.
New
Cui et al., Chongqing, China. In Neuro Oncol, Dec 2015
BACKGROUND: The transcription factor homeobox C9 (HOXC9) plays a crucial role in developmental regulatory systems, where it determines the specific positional identities of cells along the anteroposterior axis.
A stringent validation of mouse adipose tissue identity markers.
New
Nedergaard et al., Stockholm, Sweden. In Am J Physiol Endocrinol Metab, Jul 2015
Most of these markers unexpectedly turned out to be noninformative concerning tissue classification (Car4, Cited1, Ebf3, Eva1, Fbxo31, Fgf21, Lhx8, Hoxc8, and Hoxc9).
(1)H, (15)N and (13)C chemical shift assignments of the homeodomain of Hoxc9 in complex with the cell cycle regulator Geminin.
New
Zhu et al., Hong Kong, Hong Kong. In Biomol Nmr Assign, Apr 2015
Here we report complete chemical shift assignments of the homeodomain of Hoxc9 (Hoxc9-HD) in complex with the homeodomain binding region of Geminin (Gem-HBR), which were determined by triple resonance NMR experiments.
MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.
New
Zhu et al., Hefei, China. In Cancer Lett, Mar 2015
Here, we showed that as a new direct target, the homeobox C9 (HOXC9) gene also executes the promoting effect of miR-193a-3p on the bladder cancer chemoresistance from a systematic study of multi-chemosensitive (5637) and resistant (H-bc) bladder cancer cell lines in both cell culture and tumor-xenograft/nude mice system.
Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells.
Ding et al., In Genom Data, 2015
The homeobox protein HOXC9 is a key regulator of neuroblastoma differentiation.
Direct evidence of brown adipocytes in different fat depots in children.
Körner et al., Leipzig, Germany. In Plos One, 2014
Samples with brown-like adipocytes showed an increased expression of UCP1 (>200fold), PRDM16 (2.8fold), PGC1α and CIDEA while other brown/beige selective markers, such as PAT2, P2RX5, ZIC1, LHX8, TMEM26, HOXC9 and TBX1 were not significantly different between UCP1 positive and negative samples.
Evolving locomotion with Hoxc9.
Mallo, Portugal. In Dev Cell, 2014
(2014) show that Hoxc9 restriction of Foxp1, high levels of which specify limb-innervating motor neurons, first appeared in vertebrates concomitantly with paired appendages.
Evolving Hox activity profiles govern diversity in locomotor systems.
Dasen et al., New York City, United States. In Dev Cell, 2014
This suppression is mediated by a key regulatory domain that is specifically found in the Hoxc9 proteins of appendage-bearing vertebrates.
A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.
Logan et al., London, United Kingdom. In Plos Genet, 2014
We demonstrate that Hoxc9, which is expressed in caudal LPM where Tbx5 is not expressed, can form a repressive complex on the Tbx5 forelimb regulatory element.
Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity.
Kingwell et al., Melbourne, Australia. In Plos One, 2013
WAT genes (HOXC9, RB1) were expressed equally in the two groups.
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
Impact
Scheele et al., Copenhagen, Denmark. In Cell Metab, 2013
We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26.
Homeobox C9 is not potentially related to congenital heart disease in Chinese patients.
GeneRIF
Ma et al., Shenyang, China. In Genet Test Mol Biomarkers, 2012
We did not find any potential pathological mutations in the Hoxc9 gene among Chinese patients with congenital heart disease.
HOXC9: a key regulator of endothelial cell quiescence and vascular morphogenesis.
Review
Kroll et al., Mannheim, Germany. In Trends Cardiovasc Med, 2012
HOXC9 is highly expressed in quiescent endothelial cells and keeps the vasculature in a resting state via inhibition of interleukin-8 production.
HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.
GeneRIF
Ding et al., Augusta, United States. In Cancer Res, 2011
HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.
The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8.
GeneRIF
Kroll et al., Mannheim, Germany. In Circ Res, 2011
The data identify HOXC9 as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner
Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
GeneRIF
Dasen et al., New York City, United States. In Neuron, 2010
Hoxc9, has an essential role in organizing the motor system through global repressive activities. Hoxc9 is required for the generation of thoracic motor columns, and in its absence, neurons acquire the fates of limb-innervating populations
RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
GeneRIF
Zhu et al., Suzhou, China. In J Cancer Res Clin Oncol, 2009
Methylated state of this set of genes may be more specific to the late rather than the early stage of NSCLC.
Altered Hox expression and segmental identity in Mll-mutant mice.
Impact
Korsmeyer et al., Saint Louis, United States. In Nature, 1995
Anterior boundaries of Hoxa-7 and Hoxc-9 expression were shifted posteriorly in Mll +/- embryos, but their expression was abolished in Mll -/- embryos.
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