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Homeobox C8

Hoxc8, Hox-3.1
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Antennapedia, HOXC6, Histone, Hoxc9
Papers on Hoxc8
Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer.
New
Mao et al., Nantong, China. In Reprod Sci, Feb 2016
UNASSIGNED: Homeobox C8 (HOXC8) is a transcription factor that has been reported as a potential driver oncogene in several tumors and involved in the regulation of many cancer-related proteins.
Upregulated HOXC8 Expression Is Associated with Poor Prognosis and Oxaliplatin Resistance in Hepatocellular Carcinoma.
New
Shi et al., Nantong, China. In Dig Dis Sci, Nov 2015
AIM: In this article, we examined whether HOXC8 was associated with the poor prognosis of hepatocellular carcinoma and explored the possible underlying mechanism.
[Analysis of gastric cancer tissues genome methylation by DNA methylation chip].
New
Li et al., Zhangjiakou, China. In Zhonghua Wei Chang Wai Ke Za Zhi, Nov 2015
In the CpG islands, 123 significantly different methylated genes were identified in gastric cancer tissues, such as WNT2B, JAK2 and TPT1, while 139 significantly different methylated genes were identified in their matched adjacent tissues, such as TNFRSF4, HOXC8 and NFYA.
Genome-Wide Linkage Analysis Identifies Loci for Physical Appearance Traits in Chickens.
New
Wen et al., China. In G3 (bethesda), Oct 2015
Mb) with 1% genome-wide significant level on LGE22C19W28_E50C23 linkage group (LGE22) for crest trait was identified, which is likely very closely linked to the HOXC8.
Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis.
New
Li et al., Hefei, China. In Oncotarget, Oct 2015
In this study, we show that embigin is transcriptionally regulated by Homeobox C8 (HOXC8) in breast cancer cells and embigin expression suppresses breast tumorigenesis.
An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction.
New
Alfaidy et al., Melbourne, Australia. In Mol Med, Aug 2015
The Homeobox gene array identified a >5-fold increase in HOXA9, HOXC8, HOXC10, HOXD1, HOXD8, HOXD9 and HOXD11, while NKX 3.1 showed a >2 fold-decrease in mRNA expression compared to untreated controls.
The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.
Hunter et al., Sheffield, United Kingdom. In Plos One, 2014
Expression array analysis identified a number of miR196a targets, including MAMDC2 and HOXC8.
A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans.
Impact
Scheele et al., Copenhagen, Denmark. In Cell Metab, 2013
We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26.
Cdx1 is essential for the initiation of HoxC8 expression during early embryogenesis.
GeneRIF
Fainsod et al., Jerusalem, Israel. In Faseb J, 2012
Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation.
Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
GeneRIF
Kim et al., Seoul, South Korea. In Mol Cells, 2011
Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion.
Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma.
GeneRIF
Berger et al., Heidelberg, Germany. In Br J Cancer, 2011
HOXC8 expression is inversely related to pancreatic ductal adenocarcinoma progression and metastasis.
HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes.
GeneRIF
Nordeen et al., Aurora, United States. In Mol Cancer Res, 2010
a complex role for HOXC8 in prostate cancer, promoting invasiveness while inhibiting AR-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate
Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.
GeneRIF
Huang et al., Augusta, United States. In Cancer Res, 2010
Ratio of microRNA to HOXC8 mRNA may be an indicator of the metastatic capability of breast tumors.
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
Impact
Patel et al., New York City, United States. In Cell, 2010
Furthermore, the MLL1-CyP33 interaction is required for repression of HOXA9 and HOXC8 genes in vivo.
Regulation of TGF-beta signaling by Smad7.
Review
Chen et al., Beijing, China. In Acta Biochim Biophys Sin (shanghai), 2009
Besides, these inhibitory Smad proteins also inhibit TGF-beta/BMP signaling in the nucleus by interacting with transcriptional repressors, such as histone deacetylases, Hoxc-8, and CtBP, or disrupting the formation of the TGF-beta-induced functional Smad-DNA complexes.
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Impact
Allis et al., In Nature, 2006
Depletion of H3K4me3 causes partial release of the NURF subunit, BPTF (bromodomain and PHD finger transcription factor), from chromatin and defective recruitment of the associated ATPase, SNF2L (also known as ISWI and SMARCA1), to the HOXC8 promoter.
Specification of motoneurons from human embryonic stem cells.
Impact
Zhang et al., In Nat Biotechnol, 2005
The in vitro-generated motoneurons expressed HB9, HoxC8, choline acetyltransferase and vesicular acetylcholine transporter, induced clustering of acetylcholine receptors in myotubes, and were electrophysiologically active.
MicroRNA-directed cleavage of HOXB8 mRNA.
Impact
Bartel et al., Cambridge, United States. In Science, 2004
We find that miR-196, a miRNA encoded at three paralogous locations in the A, B, and C mammalian HOX clusters, has extensive, evolutionarily conserved complementarity to messages of HOXB8, HOXC8, and HOXD8.
[The role of Smads and related transcription factors in the signal transduction of bone morphogenetic protein inducing bone formation].
Review
Tang et al., Shanghai, China. In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2003
Smad1 and Smad5 related with transcription factors included core binding factor A1 (CBFA1), smad-interacting protein 1 (SIP1), ornithine decarboxylase antizyme (OAZ), activating protein-1 (AP-1), xenopus ventralizing homeobox protein-2 (Xvent-2), sandostatin (Ski), antiproliferative proteins (Tob), and homeodomain-containing transcriptian factor-8 (Hoxc-8), et al.
Altering the spatial determinations in the mouse embryos by manipulating the Hox genes.
Review
Brûlet et al., Paris, France. In C R Acad Sci Iii, 1993
The Hoxc-8 null mutation can induce homeosis at the anterior margin of Hoxc-8 expression, where the mosaicism observed suggests that, at least in the segmented paraxial mesoderm, the number of cells expressing a Hox gene is a determinant parameter.
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