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Homeobox C6

HOXC6, Hox-3.3, homeobox C6
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HOXC5, Hoxc8, POLYMERASE, HOXC4
Papers on HOXC6
Identification of Differential Genes Expression Profiles and Pathways of Bone Marrow Mesenchymal Stem Cells of Adolescent Idiopathic Scoliosis Patients by Microarray and Integrated Gene Network Analysis.
New
Zhang et al., Beijing, China. In Spine (phila Pa 1976), Jan 2016
Furthermore, gene signal transduction networks analysis indicated that MAP2K, SMAD3, HOXC6, HSPA6, GTF2I, CREBBP, PIK3R2 and DUSP2 may play essential roles in AIS pathogenesis and accompanied osteopenia.
The role of HOXC6 in prostate cancer development.
New
Schalken et al., Nijmegen, Netherlands. In Prostate, Dec 2015
We analyzed AR regulation and function of HOXC6 in PCa cell lines.
Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
New
Imkamp et al., Hannover, Germany. In Anticancer Res, Oct 2015
RESULTS: The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6).
Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer.
New
Schalken et al., Nijmegen, Netherlands. In Clin Cancer Res, Aug 2015
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer.
New
Mandal et al., Arlington, United States. In Biochim Biophys Acta, Jun 2015
HOXC6 is a homeobox-containing gene associated with mammary gland development and is overexpressed in variety of cancers including breast and prostate cancers.
INHIBITION OF ERN1 SIGNALING ENZYME AFFECTS HYPOXIC REGULATION OF THE EXPRESSION OF E2F8, EPAS1, HOXC6, ATF3, TBX3 AND FOXF1 GENES IN U87 GLIOMA CELLS.
New
Bikfalvi et al., In Ukr Biochem J, Mar 2015
We studied the effect of hypoxia on the expression of genes encoding the transcription factors such as E2F8 (E2F transcription factor 8), EPAS1 (endothelial PAS domain protein 1), TBX3 (T-box 3), ATF3 (activating transcription factor 3), FOXF1 (forkhead box F), and HOXC6 (homeobox C6) in U87 glioma cells with and without ERN1 signaling enzyme function.
Downregulation of HOXC6 in Serous Ovarian Cancer.
Mostafavi et al., Charlotte, United States. In Cancer Invest, 2014
Although dysregulation of several HOX genes in ovarian cancer has been reported, little is known about HOXC6 expression in epithelial ovarian cancer.
Comparison analysis in synchronous and metachronous metastatic colorectal cancer based on microarray expression profile.
Cai et al., In Hepatogastroenterology, 2014
CONCLUSIONS: Some DEGs, such as NFAT5, OLR1, ERAP2, HOXC6 and TWIST1 might play crucial roles in the regulation of CRC metastasis (both SC and MC) and by disrupting some pathways.
DNA methylation status is more reliable than gene expression at detecting cancer in prostate biopsy.
Ostrowski et al., Warsaw, Poland. In Br J Cancer, 2014
RESULTS: HOXC6, AMACR and PCA3 expression showed the best discrimination between PCa and BPH.
Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.
Sidransky et al., Baltimore, United States. In Epigenetics, 2014
We uncovered 186 downregulated genes harboring cancer specific promoter methylation including PAX1 and PAX5 and we identified 10 key tumor suppressor genes (GABRB3, HOXC12, PARP15, SLCO4C1, CDKN2A, PAX1, PIK3AP1, HOXC6, PLCB1, and ZIC4) inactivated by both promoter methylation and/or somatic mutation.
The survival predictive significance of HOXC6 and HOXC8 in esophageal squamous cell carcinoma.
Chen et al., Beijing, China. In J Surg Res, 2014
In this study, we explored the prognostic significance of the expressions of HOXC6 and HOXC8, responsible for embryonic development, by studying the specimens collected from clinical subjects during strict follow-up periods.
Deregulation of an imprinted gene network in prostate cancer.
Schulz et al., Düsseldorf, Germany. In Epigenetics, 2014
Deregulation of the network genes also correlated with EZH2 and HOXC6 overexpression.
Evaluation of protein biomarkers of prostate cancer aggressiveness.
Schmechel et al., Seattle, United States. In Bmc Cancer, 2013
RESULTS: In univariate analyses, lymph node positivity, surgical margin positivity, non-localized tumor, age at prostatectomy, and biomarkers CCND1, HMMR, IGF1, MKI67, SIAH2, and SMAD4 in malignant epithelium were significantly associated with time to BF. HMMR, IGF1, and SMAD4 remained significantly associated with BF after adjusting for clinicopathologic features while additional associations were observed for HOXC6 and MAP4K4 following adjustment.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Review
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.
GeneRIF
Mandal et al., Arlington, United States. In J Mol Biol, 2011
These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 and MLL3, in coordination with ERalpha and ERbeta, transcriptionally regulate HOXC6 in an estrogen-dependent manner.
Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis.
GeneRIF
Wacker et al., Ulm, Germany. In Dev Dyn, 2009
Hoxc6 functions are not restricted to the expected role in anterior-posterior pattern formation, but they also regulate N-tubulin, thereby having an effect on the initial formation of primary neurons in Xenopus laevis embryos
[Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].
GeneRIF
Chen et al., China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2009
Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells.
HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells.
GeneRIF
Moriuchi et al., Sapporo, Japan. In J Cell Mol Med, 2007
HOXC6 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells.
Loss of HOXC6 expression induces apoptosis in prostate cancer cells.
GeneRIF
Moreno et al., Atlanta, United States. In Oncogene, 2005
proapoptotic repression targets include neutral endopeptidase (NEP) and insulin-like growth factor binding protein-3 (IGFBP-3)
The HOXC6 homeodomain-containing proteins.
Review
Gielen et al., Liège, Belgium. In Int J Biochem Cell Biol, 1998
The HOXC6 homeodomain-containing proteins act as transcription factors in the genetic control of multiple genes involved in development and cell differentiation.
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