Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer.
Nijmegen, Netherlands. In Clin Cancer Res, Aug 2015
After quantitative PCR analysis on tissue specimens and urinary sediments, eight promising biomarkers for the urinary detection of prostate cancer were selected (ONECUT2, HOXC4, HOXC6, DLX1, TDRD1, NKAIN1, MS4A8B, PPFIA2).
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Irvine, United States. In J Immunol, 2015
The selectivity of histone deacetylase inhibitor-mediated silencing of AICDA/Aicda and PRDM1/Prdm1 was emphasized by unchanged expression of HoxC4 and Irf4 (important inducers/modulators of AICDA/Aicda), Rev1 and Ung (central elements for CSR/SHM), and Bcl6, Bach2, or Pax5 (repressors of PRDM1/Prdm1 expression), as well as unchanged expression of miR-19a/b, miR-20a, and miR-25, which are not known to regulate AICDA/Aicda or PRDM1/Prdm1.
Adult human neural crest-derived cells for articular cartilage repair.
Basel, Switzerland. In Sci Transl Med, 2014
Using hyaline cartilage as a model, we showed that adult human neuroectoderm-derived nasal chondrocytes (NCs) can be constitutively distinguished from mesoderm-derived articular chondrocytes (ACs) by lack of expression of specific HOX genes, including HOXC4 and HOXD8.
[Expression of HOXC4 gene during early development in zebrafish].
Guiyang, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2013
OBJECTIVE: To investigate the mechanism of HOXC4 gene during early development in zebrafish, study it's expression in hematopoiesis system with whole mount in situ hybridization (WISH), then make a foundation work for further study of HOXC4 gene in hematopoiesis development.
Hormones and AID: balancing immunity and autoimmunity.
Milano, Italy. In Autoimmunity, 2013
Those regulatory pathways can be direct when the estrogen receptor (ER) binds the AID promoter, or indirect via activation of transcription factors that enhance AID expression (e.g., HoxC4).
Regulation of Aicda expression and AID activity.
Irvine, United States. In Autoimmunity, 2013
Transcription factors, such as HoxC4 and NF-κB, which are up-regulated in a B cell lineage-and/or differentiation stage-specific manner, regulate the induction of AID.
DNA methylation profiles of long- and short-term glioblastoma survivors.
Birmingham, United Kingdom. In Epigenetics, 2013
Our preliminary study also identified a set of CpG loci differentially hypermethylated between STS and LTS cases, including members of the homeobox gene family (HOXD8, HOXD13 and HOXC4), the transcription factors NR2F2 and TFAP2A, and Dickkopf 2, a negative regulator of the wnt/β-catenin signaling pathway.
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination.
Irvine, United States. In Crit Rev Immunol, 2006
Integration of different intracellular signal transduction pathways, as activated by these stimuli, leads to a dynamic aicda-regulating program, which involves both positively acting trans-factors, such as Pax5, HoxC4, E47, and Irf8, and negative modulators, such as Blimp1 and Id2, to restrict aicda expression primarily to germinal center B cells.