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Homeobox C13

HOXC13
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAIR, cytokeratin, CAN, HOXA9, Hoxc10
Papers on HOXC13
Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus.
New
Gurnett et al., Saint Louis, United States. In J Med Genet, Feb 2016
RESULTS: The microdeletions share a minimal non-coding region overlap upstream of HOXC13, with variable phenotypes depending upon HOXC13, HOXC12 or the HOTAIR lncRNA inclusion.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Dysregulated expression of sterol O-acyltransferase 1 (Soat1) in the hair shaft of Hoxc13 null mice.
New
Awgulewitsch et al., Charleston, United States. In Exp Mol Pathol, Dec 2015
A comparative analysis of mRNA and protein expression patterns of Soat1/SOAT1 and the transcriptional regulator Hoxc13/HOXC13 in postnatal skin of FVB/NTac mice indicated co-expression in the most proximal cells of the differentiating medulla.
DNA-protein interaction dynamics at the Lamin B2 replication origin.
Giacca et al., Pisa, Italy. In Cell Cycle, 2014
In addition to the pre-RC component ORC4 and to the transcription factors USF and HOXC13, we found that 2 components of the AP-1 transcription factor, c-Fos and c-Jun, are also associated with the origin DNA during the late G1 phase of the cell cycle and that these factors interact with ORC4.
Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.
Gudas et al., New York City, United States. In J Cell Physiol, 2014
We detected the H3K9me3 mark at HOXB7, HOXC10, HOXC13, and HOXD8 at levels higher in OKF6-TERT1R than in SCC-9 cells; at IRX1 and SIX2 the H3K9me3 levels were conversely higher in SCC-9 than in OKF6-TERT1R.
The genetics of fat distribution.
Review
Kovacs et al., Leipzig, Germany. In Diabetologia, 2014
Moreover, recent GWAS identified several polymorphisms in developmental genes (including TBX15, HOXC13, RSPO3 and CPEB4) strongly associated with FD.
Skin tumors with matrical differentiation: lessons from hair keratins, beta-catenin and PHLDA-1 expression.
Cribier et al., Paris, France. In J Cutan Pathol, 2014
METHODS: In 36 prospectively collected tumors, K31, K35, CK17, LEF1, HOXC13, beta-catenin and PHLDA1 expressions were evaluated.
Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.
Gudas et al., New York City, United States. In Exp Cell Res, 2014
HOXB7, HOXC10, HOXC13, and HOXD8 transcripts are higher in SCC-9 than in OKF6-TERT1R cells; using ChIP (chromatin immunoprecipitation) we detected PRC2 protein SUZ12 and the epigenetic H3K27me3 mark on histone H3 at these genes in OKF6-TERT1R, but not in SCC-9 cells.
Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in well‑differentiated and dedifferentiated human liposarcomas.
De Chiara et al., Napoli, Italy. In Oncol Rep, 2013
In this study, we evaluated the expression of HOXC13, included in this chromosomal region, in a series of adipocytic tumors.
Autosomal recessive transmission of a rare KRT74 variant causes hair and nail ectodermal dysplasia: allelism with dominant woolly hair/hypotrichosis.
Dahl et al., Uppsala, Sweden. In Plos One, 2013
Autosomal recessive (AR) PHNED has previously been associated with mutations in either KRT85 or HOXC13 on chromosome 12p11.1-q14.3.
Knockdown of BMI-1 causes cell-cycle arrest and derepresses p16INK4a, HOXA9 and HOXC13 mRNA expression in HeLa cells.
GeneRIF
Hu et al., Wuhan, China. In Med Oncol, 2011
knockdown of BMI-1 expression can induce cell-cycle arrest and up-regulate p16INK4a, HOXA9 and HOXC13 in HeLa cells
The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation.
GeneRIF
Awgulewitsch et al., Charleston, United States. In J Invest Dermatol, 2011
data support a regulatory model of keratinocyte differentiation in which HOXC13-dependent activation of Foxn1 is part of a regulatory cascade controlling the expression of hair and nail terminal differentiation markers
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Impact
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
DNA replication, development and cancer: a homeotic connection?
Review
Biamonti et al., Pisa, Italy. In Crit Rev Biochem Mol Biol, 2010
A one-hybrid screen to detect proteins with affinity for the lamin B2 replication origin identified three homeotic proteins, namely HoxA13, HoxC10 and HoxC13.
Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review.
Review
GeneRIF
Pavlović et al., Belgrade, Serbia. In Cancer Genet Cytogenet, 2009
To our knowledge, this is the first case of t(11;12)(p15;q13) in de novo AML-M4 in association with FLT3 ITD mutation. Coexistence of NUP98-HOXC13 fusion and FLT3 ITD mutation is likely relevant in the process of leukemogenesis
The homeotic protein HOXC13 is a member of human DNA replication complexes.
GeneRIF
Falaschi et al., Pisa, Italy. In Cell Cycle, 2009
Results show that HOXC13 is a member of human replicative complexes.
[Expression of HOXC13 in ameloblastoma].
GeneRIF
Hou et al., Shenyang, China. In Zhonghua Kou Qiang Yi Xue Za Zhi, 2007
HOXC13 was highly expressed in ameloblastoma. Heterogeneous expression could improve the epithelial proliferation, and its loss may lead to the cornification and degeneration of epithelial cells.
Hox in hair growth and development.
Review
Awgulewitsch, Charleston, United States. In Naturwissenschaften, 2003
The first Hox gene shown to play a universal role in hair follicle development is Hoxc13, as both Hoxc13-deficient and overexpressing mice exhibit severe hair growth and patterning defects.
Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).
Review
Johansson et al., Lund, Sweden. In Genes Chromosomes Cancer, 2003
We here report a de novo acute myeloid leukemia with a t(11;12)(p15;q13), resulting in a novel NUP98/HOXC13 fusion.
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