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Homeobox C10

Hoxc10, Hox-3.6
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HOXA9, CAN, HOXC13, HOXA10, Hoxc9
Papers on Hoxc10
Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits.
New
Klöting et al., Leipzig, Germany. In Obesity (silver Spring), Jan 2016
Here, the hypothesis that human adipose tissue (AT) expression of the developmental genes homeobox transcription factors C9 (HOXC9) and C10 (HOXC10) is fat depot-specific and related to obesity-related traits was tested.
HOXC10 up-regulation contributes to human thyroid cancer and indicates poor survival outcome.
New
Peng et al., Shanghai, China. In Mol Biosyst, Nov 2015
The role and clinical implication of homeodomain-containing gene 10 (HOXC10) in human thyroid cancer is poorly understood.
An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction.
New
Alfaidy et al., Melbourne, Australia. In Mol Med, Aug 2015
The Homeobox gene array identified a >5-fold increase in HOXA9, HOXC8, HOXC10, HOXD1, HOXD8, HOXD9 and HOXD11, while NKX 3.1 showed a >2 fold-decrease in mRNA expression compared to untreated controls.
Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.
Gudas et al., New York City, United States. In J Cell Physiol, 2014
We detected the H3K9me3 mark at HOXB7, HOXC10, HOXC13, and HOXD8 at levels higher in OKF6-TERT1R than in SCC-9 cells; at IRX1 and SIX2 the H3K9me3 levels were conversely higher in SCC-9 than in OKF6-TERT1R.
Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations.
Taylor et al., In Hum Mol Genet, 2014
Previously unreported rs2811337-G near TMCC1 was associated with increased WHR (β ± SE, 0.048 ± 0.008, P = 7.7 × 10(-9)) as was rs7302703-G in HOXC10 (β = 0.044 ± 0.008, P = 2.9 × 10(-7)) and rs936108-C in PEMT (β = 0.035 ± 0.007, P = 1.9 × 10(-6)).
Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer.
Oesterreich et al., Houston, United States. In Sci Transl Med, 2014
For the homeobox gene HOXC10, methylation occurred in a CpG shore, which overlapped with a functional ER binding site, causing repression of HOXC10 expression.
Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.
Gudas et al., New York City, United States. In Exp Cell Res, 2014
HOXB7, HOXC10, HOXC13, and HOXD8 transcripts are higher in SCC-9 than in OKF6-TERT1R cells; using ChIP (chromatin immunoprecipitation) we detected PRC2 protein SUZ12 and the epigenetic H3K27me3 mark on histone H3 at these genes in OKF6-TERT1R, but not in SCC-9 cells.
Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements.
Menke et al., Athens, United States. In Dev Biol, 2013
Earlier studies suggested that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking.
Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.
Rosen et al., Boston, United States. In Dev Dyn, 2012
RESULTS: The knee is enriched for the hindlimb patterning genes Hoxc9, Hoxc10, and Tbx4 and for Tgfbi, Rspo2, and Sfrp2, factors involved in transforming growth factor-beta/bone morphogenetic protein (TGFβ/BMP) and Wnt signaling.
HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.
Mandal et al., Arlington, United States. In J Mol Endocrinol, 2012
HOXC10 is a critical player in the development of spinal cord, formation of neurons, and associated with human leukemia.
[The preparation of rabbit antiserum against gekko japonicus Hoxc10 and it's property identification].
Gu et al., Nantong, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
AIM: Prepare the rabbit antiserum against gecko japonicus Hoxc10 and to identify its properties.
Homeotic proteins participate in the function of human-DNA replication origins.
Falaschi et al., Pisa, Italy. In Nucleic Acids Res, 2010
The described interactions are not restricted to a single origin nor to a single homeotic protein (also HOXC10 binds the lamin B2 origin in vivo).
Reduction in inflammatory gene expression in skeletal muscle from Roux-en-Y gastric bypass patients randomized to omentectomy.
Flynn et al., Nashville, United States. In Plos One, 2010
Evidence for the activation of skeletal muscle satellite cells was inferred from the up-regulation of HOXC10.
DNA replication, development and cancer: a homeotic connection?
Review
Biamonti et al., Pisa, Italy. In Crit Rev Biochem Mol Biol, 2010
A one-hybrid screen to detect proteins with affinity for the lamin B2 replication origin identified three homeotic proteins, namely HoxA13, HoxC10 and HoxC13.
HOXC10 as a potential marker for discriminating between amnion- and decidua-derived mesenchymal stem cells.
GeneRIF
Lee et al., Seoul, South Korea. In Cloning Stem Cells, 2009
Data demonstrate that HOXC10 is a gene that may discriminate between amnion-derived mesenchymal stem cells (MSCs) and decidua-derived MSCs.
Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants.
GeneRIF
Carpenter et al., Los Angeles, United States. In Int J Biol Sci, 2008
regulates vertebral identity at the transition from thoracic to lumbar and lumbar to sacral regions
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons.
GeneRIF
Capecchi et al., Salt Lake City, United States. In Development, 2008
Hoxc10 and Hoxd10 play key roles in establishing lumbar motoneuron columnar, divisional and motor pool identity
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.
GeneRIF
Cho et al., Ann Arbor, United States. In Cancer Res, 2007
Cervical cancer cells with high endogenous levels of HOXC10 were less invasive after short hairpin RNA-mediated knockdown of HOXC10 expression; findings support a key role for the HOXC10 homeobox protein in cervical cancer progression
Expression patterns of Hox10 paralogous genes during lumbar spinal cord development.
GeneRIF
Carpenter et al., Los Angeles, United States. In Gene Expr Patterns, 2006
The three paralogous genes, Hoxa10, Hoxc10, and Hoxd10, are all expressed in the lumbar spinal cord and have distinct expression patterns.
Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity.
Impact
Tabin et al., Boston, United States. In Science, 1999
Misexpression of Pitx1 in the chick wing bud induced distal expression of Tbx4, as well as HoxC10 and HoxC11, which are normally restricted to hindlimb expression domains.
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