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Homeobox B6

HOXB6, Hox-2.2, HOX2B
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HOXB7, ACID, Hoxb8, HOXB4
Papers using HOXB6 antibodies
A new case of acromegaloid facial appearance (AFA) syndrome with an expanded phenotype
Barsh Gregory S et al., In PLoS Biology, 1999
... Hoxb6-Cre transgenic mice (kindly provided by ...
Papers on HOXB6
Hoxb6 can interfere with somitogenesis in the posterior embryo through a mechanism independent of its rib-promoting activity.
Mallo et al., Portugal. In Development, Jan 2016
We show here that the linker region (LR) connecting the homeodomain and the hexapeptide is essential for Hoxb6 rib-promoting activity.
Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.
Wellik et al., Ann Arbor, United States. In Development, Dec 2015
Genetic loss of all three Hox6 paralogs (Hoxa6, Hoxb6 and Hoxc6) leads to a dramatic loss of endoderm-derived endocrine cells, including insulin-secreting β-cells, and to mild delays and disruptions in pancreatic branching and exocrine differentiation.
Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer Risk.
Pharoah et al., Cambridge, United Kingdom. In Cancer Epidemiol Biomarkers Prev, Oct 2015
RESULTS: Gene set enrichment analysis identified six networks centered on TF genes (HOXB2, HOXB5, HOXB6, HOXB7 at 17q21.32 and HOXD1, HOXD3 at 2q31) that were significantly enriched for genes from the risk-associated end of the ranked list (P < 0.05 and FDR < 0.05).
Epigenetic repression of HOXB cluster in oral cancer cell lines.
Nunes et al., Salvador, Brazil. In Arch Oral Biol, 2014
RESULTS: Methylation greater than 50% was detected in HOXA11, HOXA6, HOXA7, HOXA9, HOXB1, HOXB2, HOXB3, HOXB4, HOXB5, HOXB6, HOXC8 and HOXD10.
Regulation of endometrial receptivity by the highly expressed HOXA9, HOXA11 and HOXD10 HOX-class homeobox genes.
Zhu et al., Wuhan, China. In Hum Reprod, 2014
PARTICIPANTS/MATERIALS, SETTING AND METHODS: Analysis of a gene expression profile set in the public domain consisting of 504 samples representing 95 different normal human tissues, showed that in addition to HOXA10, also HOXA9, HOXA11, HOXB6 and HOXD10 mRNA showed increased expression in the human endometrium (16 samples).
Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance.
Lock et al., Sydney, Australia. In Bmc Genomics, 2013
Differential methylation of CAPS2, ARHGAP21, ARX and HOXB6 were confirmed by locus specific analysis.
Hypospadias and genes related to genital tubercle and early urethral development.
Shaw et al., Stanford, United States. In J Urol, 2013
MATERIALS AND METHODS: We examined 293 relatively common tag single nucleotide polymorphisms in BMP4, BMP7, FGF8, FGF10, FGFR2, HOXA13, HOXD13, HOXA4, HOXB6, SRY, WT1, WTAP, SHH, GLI1, GLI2 and GLI3.
Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine.
Mallo et al., Portugal. In Proc Natl Acad Sci U S A, 2013
In contrast, the enhancer could still interact with Hoxb6 and Pax3 to promote rib formation.
Region-specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6-positive caudal-lateral primitive mesoderm.
Nishikawa et al., Kōbe, Japan. In Exp Hematol, 2013
Etv2 ablation in caudal-lateral mesoderm by Hoxb6 Cre or Hoxb6CreER transgene affected vitelline plexus formation and intra-aortic hematopoietic clusters.
Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus.
Fitzgerald et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia.
Aetiology of hypospadias: a systematic review of genes and environment.
Roeleveld et al., Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
An autosomal recessive syndrome of severe cognitive impairment, dysmorphic facies and skeletal abnormalities maps to the long arm of chromosome 17.
Alkuraya et al., Riyadh, Saudi Arabia. In Clin Genet, 2011
Two candidate genes, HOXB6 and PPP1R9B were sequenced but no pathogenic alterations were identified.
MicroRNA programs in normal and aberrant stem and progenitor cells.
Chen et al., Stanford, United States. In Genome Res, 2011
Finally, we demonstrated that SPT-miRNAs coordinately regulate genes that are known to play roles in controlling HSC self-renewal, such as Hoxb6 and Hoxa4.
HOX gene expression in phenotypic and genotypic subgroups and low HOXA gene expression as an adverse prognostic factor in pediatric ALL.
Trka et al., Praha, Czech Republic. In Pediatr Blood Cancer, 2011
The RNA expression of HOXB6 and CDX2 genes was exclusively detected in leukemic cells but not in B-lineage cells at any of the studied developmental stages.
A Tlx2-Cre mouse line uncovers essential roles for hand1 in extraembryonic and lateral mesoderm.
Morikawa et al., In Genesis, 2010
To determine if Hand1 expression in extraembryonic mesoderm is essential for embryonic survival, Hand1 was conditionally deleted using the HoxB6-Cre mouse line that expresses Cre in extraembryonic and lateral mesoderm.
Induction of HoxB transcription by retinoic acid requires actin polymerization.
Blasi et al., Milano, Italy. In Mol Biol Cell, 2009
Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes.
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbud.
Mackem et al., Bethesda, United States. In Dev Dyn, 2009
Hoxb6CreER(T) line provides a valuable tool for analyzing gene function, as well as lineage tracing studies using genetic cell marking, in several developing systems.
Unique spatial and cellular expression patterns of Hoxa5, Hoxb4, and Hoxb6 proteins in normal developing murine lung are modified in pulmonary hypoplasia.
Chinoy et al., Boston, United States. In Birth Defects Res A Clin Mol Teratol, 2008
Altered Hox protein temporal and cellular balance of expression either contributes to pulmonary hypoplasia or functions as a compensatory mechanism attempting to correct abnormal lung development and maturation in this condition.
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Lawrence et al., San Francisco, United States. In Blood, 2005
Overexpression of HOXB6 in marrow progenitors enhances self-renewal and cell growth in vitro. In vivo, it can result in acute myeloid leukemia with a median latency of 223 days.
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