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Homeobox B4

HOXB4, Hox-2.6
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fucosyltransferase, CD34, HAD, POLYMERASE
Papers using HOXB4 antibodies
Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice
Supplier
Emerson Stephen G. et al., In The Journal of Experimental Medicine, 1997
... A genomic clone containing the human HOXB4 gene was isolated from a human genomic placental library (CLONTECH Laboratories, Inc.) by hybridization ...
Papers on HOXB4
Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression.
New
Broxmeyer et al., Indianapolis, United States. In Leukemia, Jan 2016
Furthermore, we showed that OAC1 treatment led to OCT4-mediated upregulation of HOXB4.
Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish.
New
He et al., Guiyang, China. In Clin Exp Pharmacol Physiol, Dec 2015
However, the effect of homeobox protein Hox-B4 (HOXB4) ectopic expression on the development of hemangioblasts has not been fully addressed.
HOXA4 provides stronger engraftment potential to short-term repopulating cells than HOXB4.
New
Bijl et al., Montréal, Canada. In Stem Cells Dev, Nov 2015
Endogenous expression of HOXA4 is 10-fold higher than HOXB4 in embryonic primitive hematopoietic cells undergoing self-renewal suggesting a more potent capacity of HOXA4 to expand HSC.
Identification of differentially methylated markers among cytogenetic risk groups of acute myeloid leukemia.
Fang et al., Seattle, United States. In Epigenetics, 2014
Specific risk-group associated DMRs were located near genes previously known to play a role in AML or other malignancies, such as MN1, UHRF1, HOXB3, and HOXB4, as well as TRIM71, the function of which in cancer is not well characterized.
The Important Role of FLT3-L in Ex Vivo Expansion of Hematopoietic Stem Cells following Co-Culture with Mesenchymal Stem Cells.
Zarif et al., Tehrān, Iran. In Cell J, 2014
After ten days of culture, total nucleated cell count (TNC), cluster of differentiation 34+(CD34(+)) cell count, colony forming unit assay (CFU), long-term culture initiating cell (LTC-IC), homeobox protein B4 (HoxB4) mRNA and surface CD49d expression were evaluated.
Systems biology of megakaryocytes.
Review
Kaushansky et al., Seattle, United States. In Adv Exp Med Biol, 2013
Additional signals activated by these secondary mediators include mammalian target of rapamycin; β(beta)-catenin; the G proteins Rac1, Rho, and CDC42; several transcription factors, including hypoxia-inducible factor 1α(alpha), the homeobox-containing proteins HOXB4 and HOXA9, and a number of signaling mediators that are reduced, including glycogen synthase kinase 3α(alpha) and the FOXO3 family of forkhead proteins.
[Ex vivo expansion of human hematopoietic stem/progenitor cells by TAT-HOXB4 homeoprotein and the prospect of its clinical use].
Review
Chen et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2013
As one member of the HOX gene family, HOXB4 gene is a specific transcription factor, playing an important role in regulating balance between self-renewal and differentiation of hematopoietic stem/ progenitor cells (HSPC).
Studies on HOXB4 expression during differentiation of human cytomegalovirus-infected hematopoietic stem cells into lymphocyte and erythrocyte progenitor cells.
GeneRIF
Mei-Xian et al., China. In Cell Biochem Biophys, 2012
cytomegalovirus infection markedly down-regulated HOXB4 expression which affected proliferation and differentiation of erythroid and lymphocyte progenitor cells.
Dynamic HoxB4-regulatory network during embryonic stem cell differentiation to hematopoietic cells.
GeneRIF
Tan et al., Iowa City, United States. In Blood, 2012
Down-regulation of mitochondria and lysosomal genes by HoxB4 plays a role in the impaired lymphoid lineage development from embryonic stem cells-derived hematopoietic stem cells.
Mechanism of action of HOXB4 on the hematopoietic differentiation of embryonic stem cells.
Review
Jackson et al., Edinburgh, United Kingdom. In Stem Cells, 2012
More complex differentiation induction strategies including coculture with stromal cells derived from sites of hematopoietic activity in vivo and enforced expression of reprogramming transcription factors, such as HOXB4, have been required to increase the efficiency of the differentiation procedure and to produce these most potent hematopoietic stem cells.
HOXB4 can enhance the differentiation of embryonic stem cells by modulating the hematopoietic niche.
GeneRIF
Forrester et al., Edinburgh, United Kingdom. In Stem Cells, 2012
HOXB4 activation can generate a paracrine as well as a cell autonomous effect on hematopoietic differentiation.
Hox B4 as potential marker of non-differentiated cells in human cervical cancer cells.
GeneRIF
Salcedo et al., Mexico. In J Cancer Res Clin Oncol, 2012
Hox B4 protein is present in the precursor lesions as CC cells, suggesting that Hox B4 could be a protein related to the neoplastic state (non-differentiated cells) of human cervical epithelium.
HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
GeneRIF
Vigon et al., Paris, France. In Haematologica, 2012
Comparative transcriptome analysis of CD34(+) cells subjected or not to HOXB4 or HOXC4 demonstrated that both homeoproteins regulate the same set of genes, some of which encode key hematopoietic factors and signaling molecules.
Molecular mechanisms of thrombopoietin signaling.
Review
Kaushansky, San Diego, United States. In J Thromb Haemost, 2009
Additional signals activated by these secondary mediators include mammalian target of rapamycin, beta-catenin, hypoxia-inducible factor 1alpha and the homeobox proteins HOXB4 and HOXA9, and a number that are reduced, including glycogen synthase kinase 3alpha and the FOXO3 family of forkhead proteins.
[Mechanisms underlying the expression regulation of HOXB4 transcription in hematopoietic stem cells - review].
Review
Chen et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2008
As a member of the hox gene family, hoxB4 gene encodes a class of DNA-dependent homeobox domain nucleoprotein, which is a specific transcription factor, playing an important role in regulating the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs).
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block.
Impact
Nerlov et al., Monterotondo, Italy. In Nat Immunol, 2006
Loss of hematopoietic stem cell function was associated with decreased expression of Cdkn1a (encoding the cell cycle inhibitor p21(cdk)), Sfpi1, Hoxb4 and Bmi1 (encoding the transcription factors PU.1, HoxB4 and Bmi-1, respectively) and altered integrin expression in Lin(-)Sca-1(+)c-Kit(+) cells, whereas PU.1 was upregulated in erythroid progenitors.
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein.
Impact
Sauvageau et al., Montréal, Canada. In Nat Med, 2003
Retroviral overexpression of the human homeobox B4 (HOXB4) gene in mouse bone marrow cells enables over 40-fold expansion of HSCs in vitro.
Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein.
Impact
Fichelson et al., Paris, France. In Nat Med, 2003
Of these, the HOXB4 homeoprotein protein is of particular interests as it promotes the expansion of mouse HSCs without inducing the development of leukemia.
A role for Wnt signalling in self-renewal of haematopoietic stem cells.
Impact
Weissman et al., Durham, United States. In Nature, 2003
Furthermore, activation of Wnt signalling in HSCs induces increased expression of HoxB4 and Notch1, genes previously implicated in self-renewal of HSCs.
The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential.
Impact
Sauvageau et al., Montréal, Canada. In Immunity, 2003
We previously showed that HOXB4 is a potent stimulator of hematopoietic stem cell (HSC) proliferation in vivo and ex vivo.
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