London, United Kingdom. In Lancet, Feb 2016
There is now greater understanding for the genetic basis of familial prostate cancer with identification of rare but high-risk mutations (eg, BRCA2, HOXB13) and low-risk but common alleles (77 identified so far by genome-wide association studies) that could lead to targeted screening of patients at risk.
Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.
Shanghai, China. In Prostate, Sep 2015
Enrichment analysis indicated that genomic regions in the following 15 categories were enriched for the PCa risk-associated SNPs: exons, CpG regions, 6 TFs (AR, ERG, FOXA1, HOXB13, CTCF, and NR3C1), 5 HMs (H3K4me1, H3K4me2, H3K4me3, H3K27AC, and H3T11P), DHSs and POLR2A.
Young-age prostate cancer.
Kuwait, Kuwait. In J Clin Pathol, Jul 2015
Recently, a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features.
HOXB13, RFX6 and prostate cancer risk.
Oslo, Norway. In Nat Genet, 2014
A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression.