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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Homeobox B13

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, MEN, IL-17RB, AGE, CAN
Papers on HOXB13
Prevalence of the HOXB13 G84E mutation in Danish men treated by radical prostatectomy and correlations with prostate cancer risk and aggressiveness.
Sørensen et al., Århus, Denmark. In Bju Int, Feb 2016
OBJECTIVE: To determine the prevalence of the HOXB13 G84E mutation (rs138213197) in Danish men with/without prostate cancer (PC) and to investigate possible correlations between HOXB13 mutation status and clinicopathological parameters associated with tumor aggressiveness.
Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer.
Bieberich et al., Baltimore, United States. In Cancer Res, Feb 2016
We hypothesized that driving combined MYC overexpression and Pten loss using recently characterized Hoxb13 transcriptional control elements that are active in prostate luminal epithelial cells would induce the development of genomic instability and aggressive disease with metastatic potential.
HOXB13-mediated suppression of p21WAF1/CIP1 regulates JNK/c-Jun signaling in prostate cancer cells.
Kim et al., Kwangju, South Korea. In Oncol Rep, Feb 2016
Our previous studies demonstrated that most castration- resistant prostate cancers (CRPC) overexpress the HOXB13 transcription factor to confer positive growth signals.
Prostate cancer.
de Bono et al., London, United Kingdom. In Lancet, Feb 2016
There is now greater understanding for the genetic basis of familial prostate cancer with identification of rare but high-risk mutations (eg, BRCA2, HOXB13) and low-risk but common alleles (77 identified so far by genome-wide association studies) that could lead to targeted screening of patients at risk.
Screening for Familial and Hereditary Prostate Cancer.
Powell et al., Boston, United States. In Int J Cancer, Jan 2016
The strongest predictors are the BRCA2 mutations, and the highly penetrant G84E mutation in HOXB13.
Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.
Pollak et al., United States. In Breast Cancer Res, Dec 2015
We evaluated the prognostic value of the Breast Cancer Index (BCI), a continuous risk index based on a combination of HOXB13:IL17BR and molecular grade index, in women with early breast cancer treated with either tamoxifen alone or tamoxifen plus octreotide in the NCIC MA.14 phase III clinical trial (
Hoxb13, a potential prognostic biomarker for prostate cancer.
Tamimi et al., Shahr Sultān, Pakistan. In Front Biosci (elite Ed), Dec 2015
HOXB13, a member of the homeobox proteins family, is a key regulator of the epithelial differentiation in the prostate gland.
HOXB13 as an immunohistochemical marker of prostatic origin in metastatic tumors.
Tuccari et al., Messina, Italy. In Apmis, Dec 2015
Recent studies suggested that HOXB13 represents a prostate-specific marker in the differential diagnosis between prostatic and urothelial carcinoma.
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.
Freedman et al., Boston, United States. In Nat Genet, Nov 2015
FOXA1 and HOXB13 colocalized at the reprogrammed AR binding sites in human tumor tissue.
CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants.
Freedman et al., Boston, United States. In Nat Med, Nov 2015
Introduction of the 'T' risk allele increased transcription of the regulatory factor 6 (RFX6) gene, increased homeobox B13 (HOXB13) binding at the rs339331 region, and increased deposition of the enhancer-associated H3K4me2 histone mark at the rs339331 region compared to lines homozygous for the 'C' protective allele.
Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.
Xu et al., Shanghai, China. In Prostate, Sep 2015
Enrichment analysis indicated that genomic regions in the following 15 categories were enriched for the PCa risk-associated SNPs: exons, CpG regions, 6 TFs (AR, ERG, FOXA1, HOXB13, CTCF, and NR3C1), 5 HMs (H3K4me1, H3K4me2, H3K4me3, H3K27AC, and H3T11P), DHSs and POLR2A.
Young-age prostate cancer.
Van der Kwast et al., Kuwait, Kuwait. In J Clin Pathol, Jul 2015
Recently, a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features.
HOXB13, RFX6 and prostate cancer risk.
Mills, Oslo, Norway. In Nat Genet, 2014
A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression.
A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.
Wei et al., Oulu, Finland. In Nat Genet, 2014
Here we find that the prostate cancer risk-associated SNP rs339331 at 6q22 lies within a functional HOXB13-binding site.
Dysregulation of the homeobox transcription factor gene HOXB13: role in prostate cancer.
Ostrander et al., Bethesda, United States. In Pharmgenomics Pers Med, 2013
In search of causative variant(s) in genes from the candidate region, a novel, potentially deleterious G84E substitution in homeobox transcription factor gene HOXB13 was observed in multiple hereditary PC families.
Association between germline HOXB13 G84E mutation and risk of prostate cancer.
Nam et al., Toronto, Canada. In J Natl Cancer Inst, 2012
The G84E mutation was more frequent among white case subjects than among white control subjects and was associated with an increased risk of prostate cancer.
Association of a HOXB13 variant with breast cancer.
Offit et al., In N Engl J Med, 2012
findings show an association of this HOXB13 variant and a risk of BRCA1/2 wild-type, familial breast cancer
A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate.
Bieberich et al., Baltimore, United States. In Prostate, 2012
The Hoxb13-transgenic system provides a powerful tool for conditional Tet operator-driven transgene expression in the normal prostate and during disease progression.
Germline mutations in HOXB13 and prostate-cancer risk.
Cooney et al., Baltimore, United States. In N Engl J Med, 2012
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.
Deschamps et al., Utrecht, Netherlands. In Development, 2011
Cdx and Wnt mutations and premature Hox13 expression also cause similar neural dysmorphology
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