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Homeobox A9

HOXA9, Abd-B, Abdominal-B
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: CAN, Meis1, NUP98, CIs, Antennapedia
Papers on HOXA9
PBX3 and MEIS1 cooperate in hematopoietic cells to drive acute myeloid leukemias characterized by a core transcriptome of the MLL-rearranged disease.
New
Chen et al., Chapel Hill, United States. In Cancer Res, Feb 2016
HOXA9 and MEIS1 are considered to be the most critical targets of MLL fusions and their co-expression rapidly induces AML.
Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.
New
Schwartz et al., Umeå, Sweden. In Genetics, Jan 2016
The bithorax complex consists of three evolutionary conserved homeotic genes Ubx, abd-A and Abd-B, which specify anterior-posterior identity of the last thoracic and all abdominal segments of the fly.
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.
New
Yoneda et al., Ōsaka, Japan. In Elife, Dec 2015
Here, we show that Nup98-HoxA9, a fusion between Nup98 and the homeobox transcription factor HoxA9, forms nuclear aggregates that frequently associate with facultative heterochromatin.
Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors.
New
Impact
So et al., Hong Kong, Hong Kong. In Nat Med, Dec 2015
Intriguingly, genetic or pharmacological inhibition of an MLL downstream target, HOXA9, which activates expression of various HR-associated genes, impairs DDR and sensitizes MLL leukemia to PARP inhibitors (PARPis).
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Roles of cofactors and chromatin accessibility in Hox protein target specificity.
New
White et al., Kuala Lumpur, Malaysia. In Epigenetics Chromatin, Dec 2015
RESULTS: We generated genome-wide binding profiles for three Hox proteins, Ubx, Abd-A and Abd-B, following transient expression in Drosophila Kc167 cells, revealing clear target specificity and a striking influence of chromatin accessibility.
Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia.
New
Impact
Somervaille et al., Manchester, United Kingdom. In Cancer Cell, Oct 2015
In in vivo analyses, FOXC1 collaborates with HOXA9 to accelerate significantly the onset of symptomatic leukemia.
The open for business model of the bithorax complex in Drosophila.
Review
New
Karch et al., Genève, Switzerland. In Chromosoma, Sep 2015
Through this molecular biology effort, and along with genetic characterizations performed by Gines Morata's group in Madrid (Sanchez-Herrero et al. 1985) and Robert Whittle's in Sussex (Tiong et al. 1985), it soon became clear that the whole BX-C encoded only three protein-coding genes (Ubx, abd-A, and Abd-B).
Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets.
Review
New
Hess et al., Ann Arbor, United States. In Oncogene, Jul 2015
UNASSIGNED: HOXA9 is a homeodomain-containing transcription factor that has an important role in hematopoietic stem cell expansion and is commonly deregulated in acute leukemias.
Stage-specific control of stem cell niche architecture in the Drosophila testis by the posterior Hox gene Abd-B.
Review
Lohmann et al., Heidelberg, Germany. In Comput Struct Biotechnol J, 2014
We address this question by reviewing the role of the Hox gene Abd-B in Drosophila testis organogenesis, which proceeds through embryonic, larval and pupal stages to reach maturation in adult stages.
Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.
Impact
Weaver et al., San Francisco, United States. In Nat Med, 2014
Specifically, in human and mouse tissue, increased matrix stiffness induced miR-18a to reduce levels of the tumor suppressor phosphatase and tensin homolog (PTEN), both directly and indirectly by decreasing levels of homeobox A9 (HOXA9).
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.
Impact
Pandolfi et al., Boston, United States. In Cell Stem Cell, 2014
We found that IDH2(R140Q) can cooperate with overexpression of HoxA9 and Meis1a and with mutations in FMS-like tyrosine kinase 3 (FLT3) to drive acute leukemia in vivo.
Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia
Review
Schreiber et al., Bethesda, United States. In Unknown Journal, 2014
We generated a novel cell line model of acute myeloid leukemia, based on the potent ability of the homeobox protein HoxA9 to block differentiation in primary murine cultures of immature myeloblasts.
Systems biology of megakaryocytes.
Review
Kaushansky et al., Seattle, United States. In Adv Exp Med Biol, 2013
Additional signals activated by these secondary mediators include mammalian target of rapamycin; β(beta)-catenin; the G proteins Rac1, Rho, and CDC42; several transcription factors, including hypoxia-inducible factor 1α(alpha), the homeobox-containing proteins HOXB4 and HOXA9, and a number of signaling mediators that are reduced, including glycogen synthase kinase 3α(alpha) and the FOXO3 family of forkhead proteins.
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Impact
Daley et al., Boston, United States. In Cell Stem Cell, 2013
HOXA9, ERG, and RORA conferred self-renewal and multilineage potential in vitro and maintained primitive CD34(+)CD38(-) cells.
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
GeneRIF
Du et al., Bethesda, United States. In Blood, 2012
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.
GeneRIF
Shi et al., Hefei, China. In Genes Dev, 2012
PHD12 facilitates the localization of MOZ onto the promoter locus of the HOXA9 gene, thereby promoting the H3 acetylation around the promoter region.
Hox-mediated regulation of doublesex sculpts sex-specific abdomen morphology in Drosophila.
GeneRIF
Yoder et al., Tuscaloosa, United States. In Dev Dyn, 2012
Dsx is a transcriptional target of Abdominal-B, and its regulation sculpts sex-specific abdomen morphology.
HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.
GeneRIF
Dicorleto et al., Cleveland, United States. In Mol Cell Biol, 2012
HOXA9 is required for TNF-alpha-dependent binding of PRMT5 to the E-selectin promoter in endothelial cells.
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.
GeneRIF
Chen et al., Chicago, United States. In Nat Commun, 2011
findings show that HOXA9 and MEIS1 are direct targets of miRNA-196b, a microRNA located adjacent to and co-expressed with HOXA9, in MLL-rearranged leukaemic cells
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