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Homeobox A5

Hoxa5, M2, Hox-1.3
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, HAD, fibrillin-1, CAN, MEN
Papers using Hoxa5 antibodies
Amyloid precursor protein mutation E682K at the alternative beta-secretase cleavage beta'-site increases Abeta generation
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De Strooper Bart et al., In The EMBO Journal, 2010
... Other antibodies purchased were as follows: anti-FLAG M2 from Sigma, goat-anti-mouse IRDye800 from Rockland, goat-anti-rabbit Alexa680 from Invitrogen, ...
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
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Into Takeshi et al., In Cellular and Molecular Life Sciences, 2009
... anti-BNIP3L (NIX) rabbit polyclonal antibody (Abcam; ab8399), anti-NDP52 (CALCOCO2) rabbit polyclonal antibody (Abcam; ab68588), anti-Flag M2 monoclonal antibody (Sigma-Aldrich; F3165), anti-LC-3 monoclonal antibody (MBL; M115-2), anti-Lys63-linked polyUb rabbit ...
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
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Negishi Masahiko et al., In Nucleic Acids Research, 2008
... RIF, SR12813, cycloheximide (CHX), TCPOBOP, anti-FLAG-M2 HRP-conjugated antibody and FLAG-M2 agarose were purchased from Sigma-Aldrich (St Louis, MO, USA); CITCO from BioMol (Plymouth Meeting, PA, USA); ...
Glycans on influenza hemagglutinin affect receptor binding and immune response.
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Hauser Charlotte, In PLoS ONE, 2008
... from Abcam (Cambridge, MA), β-actin (sc-1616-R) from Santa Cruz Biotechnology (Santa Cruz, CA), and monoclonal: M2 (ab5416), and tubulin (ab6160) from Abcam and H5 (MCA2660, used ...
A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing
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Rios Rosa M. et al., In The Journal of Cell Biology, 2008
... Monoclonal anti–α-tubulin, anti–γ-tubulin (clone GTU-88), and anti-flag M2 were obtained from Sigma-Aldrich, anti-GFP was obtained from Abnova, and anti-GM130, anti-AKAP450, and ...
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Papers on Hoxa5
Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study.
New
Crews et al., Baltimore, United States. In Am J Nephrol, Feb 2016
m2 accompanied by 25% eGFR decline, CKD-related hospitalization or death or end-stage renal disease identified by linkage to the US Renal Data System registry.
Outcomes of bariatric surgery in HIV-positive individuals.
New
Kapembwa et al., London, United Kingdom. In Minerva Chir, Feb 2016
Their mean age was 46 years (range 33 - 66) with a median BMI of 43 kg/m2 (range 37 - 55).
Glomerular size reduction associated with severe cardiorenal syndrome.
New
Golestaneh et al., In Clin Nephrol, Feb 2016
m2), and history of tobacco use.
Preventing Weight Gain in Women in Rural Communities: A Cluster Randomised Controlled Trial.
New
Teede et al., Melbourne, Australia. In Plos Med, Jan 2016
From October 2012 to April 2014 we studied 649 women, mean age 39.6 yr (+/- SD 6.7) and BMI of 28.8 kg/m2 (+/- SD 6.9) with the primary outcome weight change between groups at 1 yr.
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial.
New
Impact
Ram et al., Zürich, Switzerland. In Jama, Jan 2016
Temozolomide (150-200 mg/m2/d) was given for 5 days of each 28-day cycle.
HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer.
New
Impact
Huelsken et al., Lausanne, Switzerland. In Cancer Cell, Jan 2016
Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify a reciprocal feedback between HOXA5 and Wnt signaling.
Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate.
New
Impact
Barker et al., Singapore, Singapore. In Cancer Cell, Jan 2016
In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.
A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate.
New
Nystrom et al., Linköping, Sweden. In Plos One, Dec 2015
kg/m2 to 22.30±1.7 kg/m2, p = 0.24 nuts: from 22.54±2.26
The effect of macronutrients on glycaemic control: a systematic review of dietary randomised controlled trials in overweight and obese adults with type 2 diabetes in which there was no difference in weight loss between treatment groups.
Review
New
Thompson et al., Birmingham, United Kingdom. In Br J Nutr, Dec 2015
Inclusion criteria included RCT with minimum 6 months duration, with participants having BMI≥25·0 kg/m2, a diagnosis of T2DM using HbA1c, and no statistically significant difference in mean weight loss at the end point of intervention between dietary arms.
Heidelberg Edge Perimeter: The New Method of Perimetry.
Review
New
Misiuk-Hojło et al., Wrocław, Poland. In Adv Clin Exp Med, Nov 2015
The test uses randomly flickering points in medium illumination (50 cd/m2).
Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.
New
Impact
Mineralocorticoid Receptor Antagonist Tolerability Study–Diabetic Nephropathy (ARTS-DN) Study Group et al., Hong Kong, Hong Kong. In Jama, Oct 2015
m2 or lower.
[Myopathy in patients with Waldenströms macroglobulinemia. A case study and an overview of autoimmune expressions of type IgM monoclonal immunoglobulins].
Review
New
Mayer et al., In Vnitr Lek, Sep 2015
Therefore the treatment with anti-CD20 monoclonal antibody (Mabthera) 375 mg/m2 i. v. was started, administered once a month, with cyclophosphamide 500 mg/m2 i. v. on days 1 and 15 of a 28-day cycle, and dexamethasone 20 mg from 1st through to 4th days and 15th through to 18th days of the treatment cycle.
[The profile of patients undergoing bariatric surgery in the Brazilian Unified National Health System: a systematic review].
Review
New
Barreto et al., Belo Horizonte, Brazil. In Cad Saude Publica, Aug 2015
Patients had a mean age of 41.4 years and mean body mass index of 48.6kg/m2; 21% were males, 61% hypertensive, 22% diabetics, and 31% presented sleep apnea.
Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial.
New
Impact
AMETHYST-DN Investigators et al., Rochester, United States. In Jama, Aug 2015
m2 and serum potassium level >5.0 mEq/L).
Bariatric Surgery for Type 2 Diabetes Mellitus in Patients with BMI <30 kg/m2: A Systematic Review and Meta-Analysis.
Review
Tian et al., Chengdu, China. In Plos One, 2014
We conducted a systemic review and meta-analysis to investigate the metabolic changes after surgical treatment in diabetic patients with body mass index (BMI) <30 kg/m2.
Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma.
GeneRIF
Nunes et al., São Paulo, Brazil. In Int J Oncol, 2012
since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC.
The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts.
GeneRIF
Jeannotte et al., Québec, Canada. In Endocrinology, 2012
Hoxa5, a stroma-specific gene, plays a significant role in ovarian biology and may be involved in ovarian cancer predisposition
HOX genes in pancreatic development and cancer.
GeneRIF
Morgan et al., In Jop, 2011
Studies suggest that HOXA4, HOXA5 and HOXB4 provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer.
Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation.
GeneRIF
Holterhus et al., Kiel, Germany. In Sex Dev, 2010
Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation.
Level of HOXA5 hypermethylation in acute myeloid leukemia is associated with short-term outcome.
GeneRIF
Lee et al., Pusan, South Korea. In Korean J Lab Med, 2010
The methylation percentage of HOXA5 in AML patients was higher than that of HOXA5 in control patients.
More papers using Hoxa5 antibodies
Methemoglobinemia: from diagnosis to treatment
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Usha Lydia et al., In Journal of Translational Medicine, 2007
... numbers of ovarian cancer cells were lysed and immunoblotted for RNR M2 (1:1000, rabbit anti-human M2 antibody, Novus Biologicals [Littleton, CO]) and RNR ...
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
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Silke John et al., In The Journal of Cell Biology, 2006
... Technology), anti–NF-κB p50 (Santa Cruz), anti–β-actin (Sigma-Aldrich), anti-ubiquitin (Cell Signaling Technology), anti-TRAF3 (BD Biosciences), anti–FLAG M2 (Sigma-Aldrich), anti–IgG biotin (Jackson ImmunoResearch Laboratories), and anti-VSV (MBL International) ...
Complete genome sequence of the fish pathogen Flavobacterium psychrophilum
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Watanabe Hirofumi et al., In BMC Research Notes, 2006
... M2: MidRange PFG Marker I (New England Biolabs).
Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy
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Musaro Antonio, In PLoS ONE, 2005
... For immunoprecipitation, Ez view anti-FLAG M2 affinity gel was supplied from Sigma (MO, USA) while Protein A and Dynal Immunoprecipitation Kit were from (Invitrogen, USA).AnnexinV-FITC Apoptosis detection kit was provided by Immunostep (Spain).
Effects of γ-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast
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Qi Robert Z. et al., In The Journal of Cell Biology, 2004
... The following antibodies were purchased: rabbit anti-GFP (Santa Cruz Biotechnology, Inc.), anti-Flag (monoclonal M2 and rabbit polyclonal; Sigma-Aldrich), goat anti–pericentrin 2 (C-16; Santa Cruz Biotechnology, Inc.), anti–α-tubulin (B-5-1-2; Sigma-Aldrich), ...
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.
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Means Robert E., In PLoS ONE, 2003
... (clone 9E10); mouse monoclonal anti- tubulin, Sigma-Aldrich; Rat monoclonal anti E-cadherin (Zymed); mouse monoclonal anti-Flag M2 (Sigma-Aldrich); mouse monoclonal anti-Met (clone 25F2; Cell Signaling); polyclonal anti-WWP1 antibody was ...
Study of G-protein-coupled receptor-protein interactions by bioluminescence resonance energy transfer.
Supplier
Lewin Alfred, In PLoS ONE, 2003
... 9E10 myc monoclonal antibody obtained from Roche (dilution - 1/100; Indianapolis, IN); monoclonal antibody against FLAG (M2) from Sigma (dilution - 1/500; Oakville, ON); anti-IGF-IIR from Santa Cruz Biotechnology (dilution – 1/50; Santa ...
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
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Walker Cheryl Lyn et al., In The Journal of Cell Biology, 2002
... phospho-AKT (S473), phospho-AKT (T308), and phospho-(S/T) AKT substrate (Cell Signaling Technology); Flag M2 and Flag M2 immobilized agarose beads (Sigma-Aldrich); LDH (Chemicon International); EGFP (Abcam); and β1-integrin (CLONTECH Laboratories, ...
Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells.
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Zanger Ulrich, In PLoS ONE, 2002
... Phenobarbital, TCPOBOP, anti-Flag M2 antibody and anti-Flag M2-agarose were purchased from Sigma-Aldrich; recombinant mouse TNFα from R&D systems; actinomycin D from Biomol Reserch Labs., Inc; William's ...
The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function.
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Bökel Christian, In PLoS ONE, 2001
... Leof), phosphorylated dSmad2 (1∶1000, Cell Signaling #3108), the FLAG epitope (1∶2000, Sigma (M2)), or Saxophone (1∶1000, Fabgennix).
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1
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Mayinger Peter et al., In The Journal of Cell Biology, 2000
... Sources for other antibodies are the following: mouse monoclonal anti-flag M2 (Sigma-Aldrich), rabbit polyclonal anti-GFP (Sigma-Aldrich), mouse monoclonal anti-PI(4)P (Echelon), mouse monoclonal anti–β-COP (clone mAD; Abcam), rabbit polyclonal anti-SEC23 (COP-II; ...
The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines.
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Jin Dong-Yan, In PLoS ONE, 2000
... mouse monoclonal anti-α-tubulin, clone DM1A (Sigma-Aldrich), rat monoclonal anti-HA, clone 3F10 (Roche), mouse monoclonal anti-FLAG M2 (Sigma-Aldrich), mouse monoclonal anti-penta-His (Qiagen), mouse monoclonal anti-RGS-His (Qiagen), ...
Immune inhibitory receptors
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Fallarino Francesca et al., In International Journal of Tryptophan Research : IJTR, 1999
... Anti-SOCS3 and anti-Flag M2 antibodies were purchased from Abcam and Sigma-Aldrich, respectively ...
Phosphorylation of FADD/MORT1 and Fas by kinases that associate with the membrane-proximal cytoplasmic domain of Fas
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Tschopp Jürg et al., In The Journal of Experimental Medicine, 1997
... Antibodies used for immunoprecipitation, JNK activation assay, immunofluorescence and Western blot include: anti-Flag M2 (Sigma-Aldrich), anti-FADD (Signal Transduction Labs.), anti-Fas C-20 (Santa Cruz Biotechnology, Inc.), anti-PML (promyelocytic leukemia ...
Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha.
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Linden Rafael, In PLoS ONE, 1997
... (B14), and goat IgG were purchased from Santa Cruz Biotechnology (Santa Crus, US); Anti-Flag antibody (M2) was purchased from Sigma; Anti-hexahistidine antibody was obtained from Qiagen; Antibodies to phosphor-IKK, IKKα, ...
Interleukin-15 triggers the proliferation and cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes
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Caligiuri Michael A. et al., In The Journal of Experimental Medicine, 1996
... For Western analysis the anti–FLAG M2 and M5 (Sigma-Aldrich) and probe 8 (Santa Cruz Biotechnology, Inc.) Abs were used ...
A giant nucleopore protein that binds Ran/TC4
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Bos Johannes L. et al., In The Journal of Cell Biology, 1994
... The following antibodies were used: mouse monoclonal GFP (Roche), Flag M2 (Sigma-Aldrich), rabbit polyclonal RanBP2 (Abcam), Rap1 (Santa Cruz Biotechnology, ...
Lipopolysaccharide binding protein and CD14 in LPS dependent macrophage activation
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Gebhardt Rolf et al., In Comparative Hepatology, 1992
... Immunohistochemistry with anti-M2-Pk (DF4, Schebo GmbH, Germany, A) and anti-M2-Pk (Cell Signaling, USA, A') Smooth muscle ...
Cell surface proteins of chicken hematopoietic progenitors, thrombocytes and eosinophils detected by novel monoclonal antibodies.
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Bhatia Mick, In PLoS ONE, 1991
... (P5D4: Sigma-Aldrich, Oakville ON), and the flag epitope for detecting the flag-tagged ΔEC mutant (biotinylated M2: Sigma-Aldrich), a rat monoclonal against mouse Podocalyxin (MBL, Woburn MA), and polyclonal ...
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