GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 08 Dec 2016.
Hoxa5, M2, Hox-1.3
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008] (from
Barker et al., Singapore, Singapore. In Cancer Cell, Jan 2016
In this issue of Cancer Cell, Ordóñez-Morán and colleagues describe a promising therapeutic intervention for colorectal cancers that selectively induces cancer stem cell differentiation through HOXA5 expression and Wnt signaling inhibition.
Thompson et al., Birmingham, United Kingdom. In Br J Nutr, Dec 2015
Inclusion criteria included RCT with minimum 6 months duration, with participants having BMI≥25·0 kg/m2, a diagnosis of T2DM using HbA1c, and no statistically significant difference in mean weight loss at the end point of intervention between dietary arms.
Therefore the treatment with anti-CD20 monoclonal antibody (Mabthera) 375 mg/m2 i. v. was started, administered once a month, with cyclophosphamide 500 mg/m2 i. v. on days 1 and 15 of a 28-day cycle, and dexamethasone 20 mg from 1st through to 4th days and 15th through to 18th days of the treatment cycle.
... For immunoprecipitation, Ez view anti-FLAG M2 affinity gel was supplied from Sigma (MO, USA) while Protein A and Dynal Immunoprecipitation Kit were from (Invitrogen, USA).AnnexinV-FITC Apoptosis detection kit was provided by Immunostep (Spain).
... 9E10 myc monoclonal antibody obtained from Roche (dilution - 1/100; Indianapolis, IN); monoclonal antibody against FLAG (M2) from Sigma (dilution - 1/500; Oakville, ON); anti-IGF-IIR from Santa Cruz Biotechnology (dilution – 1/50; Santa ...
... Phenobarbital, TCPOBOP, anti-Flag M2 antibody and anti-Flag M2-agarose were purchased from Sigma-Aldrich; recombinant mouse TNFα from R&D systems; actinomycin D from Biomol Reserch Labs., Inc; William's ...
... (B14), and goat IgG were purchased from Santa Cruz Biotechnology (Santa Crus, US); Anti-Flag antibody (M2) was purchased from Sigma; Anti-hexahistidine antibody was obtained from Qiagen; Antibodies to phosphor-IKK, IKKα, ...
... (P5D4: Sigma-Aldrich, Oakville ON), and the flag epitope for detecting the flag-tagged ΔEC mutant (biotinylated M2: Sigma-Aldrich), a rat monoclonal against mouse Podocalyxin (MBL, Woburn MA), and polyclonal ...