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Homeobox A10

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: HOXA9, POLYMERASE, HOX11, CAN, HAD
Papers on HOXA10
MicroRNA-320a Regulates the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting HOXA10.
Guo et al., China. In Cell Physiol Biochem, Feb 2016
The bone morphogenetic protein-inducible gene homeobox a10 (HOXA10) is a critical regulator of osteogenesis.
Regulation of inflammatory and angiogenesis mediators in a functional model of decidualized endometrial stromal cells.
Akoum et al., Québec, Canada. In Reprod Biomed Online, Jan 2016
Additionally, endometrial cells showed increased expression of homeobox HOXA10 and HOXA11 and LIFR, which are known to be involved in endometrial embryo receptivity.
Expression of Endometrial Receptivity Genes Increase After Myomectomy of Intramural Leiomyomas not Distorting the Endometrial Cavity.
Otlu et al., İstanbul, Turkey. In Reprod Sci, Jan 2016
We measured endometrial HOXA-10, HOXA-11, LIF, ITGB3, and ITGAV messenger RNA (mRNA) expressions levels before and after myomectomy/metroplasty during mid-luteal phase in participants with IM, submucosal leiomyomas (SM), and septate uterus and fertile participants without fibroids.
Overexpression of HOXA10 promotes gastric cancer cells proliferation and HOXA10(+)/CD44(+) is potential prognostic biomarker for gastric cancer.
Zhou et al., Shanghai, China. In Eur J Cell Biol, Dec 2015
This study aims to investigate the roles of homeobox A10 (HOXA10) in GC and the correlations between HOXA10/CD44 expression and GC prognosis.
CTCF negatively regulates HOXA10 expression in breast cancer cells.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, Dec 2015
Several HOX genes, such as HOXA4, HOXA5 and HOXA10, were deregulated by CTCF overexpression and knockdown in MCF-7 cells.
Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles.
Quan et al., Qingyuan, China. In Reprod Sci, Dec 2015
This study aimed to compare the expression of endometrial receptivity markers, including homeobox gene 10 (HOXA10), integrin β3, and leukemia inhibitory factor (LIF), as well as pinopode production during the implantation window in mice stimulated with raloxifene and clomiphene citrate and natural cycles.
A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer.
Cheng et al., Tampa, United States. In Oncotarget, Nov 2015
The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplored in epithelial ovarian cancer (EOC).
Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer.
Wang et al., Linyi, China. In Oncol Rep, Sep 2015
Downstream target genes of miR-1181 were searched, and it was identified that miR-1181 degraded HOXA10 by targeting its 3' untranslated region (3'UTR) in ovarian cancer cells.
Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype.
Yasui et al., Hiroshima, Japan. In Cancer Sci, Aug 2015
Our Serial Analysis of Gene Expression (SAGE) and Escherichia coli ampicillin secretion trap (CAST) analyses revealed that CDH17, REG4, OLFM4, HOXA10, DSC2, TSPAN8 and TM9SF3 are upregulated in GC and that CLDN18 is downregulated in GC.
The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility.
Taylor et al., New Haven, United States. In Cold Spring Harb Perspect Med, 2014
Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates.
Vitamin D in endometriosis: a causative or confounding factor?
Nassar et al., Beirut, Lebanon. In Metabolism, 2014
If vitamin D and its metabolites are implicated in endometriosis-associated infertility, it is likely through interference with HOXA10 gene expression.
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
Du et al., Bethesda, United States. In Blood, 2012
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10.
HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells.
Eklund et al., Chicago, United States. In J Biol Chem, 2012
found that increased Fgf2 production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin protein
Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: reduction during tumor progression and favorable prognosis.
Yasui et al., Hiroshima, Japan. In Carcinogenesis, 2012
HOXA10 expression was associated with GC with the intestinal mucin phenotype.
FKBP4 is regulated by HOXA10 during decidualization and in endometriosis.
Taylor et al., New Haven, United States. In Reproduction, 2012
regulates FKBP4 during decidualization
Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals.
Kmita et al., Montréal, Canada. In Development, 2012
Data show that the extra-embryonic function of Hoxa10, -11, and -13 genes stems from their specific expression in the allantois, an extra-embryonic hallmark of amniote vertebrates.
NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
Aplan et al., Bethesda, United States. In Blood, 2012
Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID1A, have been used to generate animal models of both lymphoid and myeloid malignancy; these models typically up-regulate HOXA cluster genes, including HOXA5, HOXA7, HOXA9, and HOXA10.
Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.
Zondervan et al., Australia. In Nat Genet, 2011
rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10.
Morphogenetic targets and genetics of undescended testis.
Saggese et al., Pisa, Italy. In Sex Dev, 2009
Mutations in the human genes encoding insulin-like factor 3 (INSL3) and its Leu-rich repeat-containing G protein-coupled receptor 8 (LGR8), homeobox A10 (HOXA10), zinc finger 214 (ZNF214) and 215 (ZNF215) have occasionally been identified but do not seem to be a frequent cause of cryptorchidism.
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Kamps et al., San Diego, United States. In Nat Cell Biol, 2007
We demonstrate that NUP98-NSD1 induces AML in vivo, sustains self-renewal of myeloid stem cells in vitro, and enforces expression of the HoxA7, HoxA9, HoxA10 and Meis1 proto-oncogenes.
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