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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Homeobox A1

HOXA1, era1, Hox-1.6
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Hoxb1, CAN, HAD, HOX11
Papers on HOXA1
Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells.
New
Guo et al., Guangzhou, China. In Lab Invest, Jan 2016
Moreover, HOXA1 methylation increased in the resistant cells using bisulfite sequencing PCR.
Improving results of surgery for fecal peritonitis due to perforated colorectal disease: A single center experience.
New
Ferrero et al., Torino, Italy. In Int J Surg, Dec 2015
METHOD: Seventy-four patients were operated on at our institution (2005-2014) for colorectal perforation with fecal peritonitis and were divided into two numerically equal groups (operated on before (ERA1-group) and after (ERA2-group) May 2010).
MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells.
New
Yang et al., Jinan, China. In Oncotarget, Nov 2015
An integrated bioinformatics analysis identified HOXA1 mRNA as the direct functional target of miR-99a, and this regulation was confirmed by luciferase reporter assay.
Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice.
New
Potts et al., Salt Lake City, United States. In Genetics, Oct 2015
Here we discriminate between these hypotheses by competing mice (Mus musculus) whose Hoxb1 gene has been replaced by Hoxa1, its highly conserved paralog, against matched wild-type controls in seminatural enclosures.
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Review
New
Mahajan et al., Tampa, United States. In Oncogene, Sep 2015
ACK1 interacts with the estrogen receptor (ER)/histone demethylase KDM3A (JHDM2a) complex, which modifies KDM3A by tyrosine phosphorylation to regulate the transcriptional outcome at HOXA1 locus to promote the growth of tamoxifen-resistant breast cancer.
A genetic framework for H2O2 induced cell death in Arabidopsis thaliana.
Brosché et al., Helsinki, Finland. In Bmc Genomics, 2014
Several transcription factors (AS1, MYB30, MYC2, WRKY70), cell death regulators (RCD1, DND1) and hormone regulators (AXR1, ERA1, SID2, EDS1, SGT1b) were essential for execution of cell death in cat2.
The genetic basis of incomitant strabismus: consolidation of the current knowledge of the genetic foundations of disease.
Review
Engle et al., Boston, United States. In Semin Ophthalmol, 2013
Disorders reviewed include Duane syndrome (DS), HOXA1 and HOXB1 syndromes, Moebius syndrome, congenital fibrosis of the extraocular muscles (CFEOM), and horizontal gaze palsy with progressive scoliosis (HGPPS).
Differential analysis of gene regulation at transcript resolution with RNA-seq.
Impact
Pachter et al., Cambridge, United States. In Nat Biotechnol, 2013
We demonstrate the accuracy of our approach through differential analysis of lung fibroblasts in response to loss of the developmental transcription factor HOXA1, which we show is required for lung fibroblast and HeLa cell cycle progression.
The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene.
GeneRIF
Hamamoto et al., Tokyo, Japan. In Int J Cancer, 2012
study demonstrates KDM3A is overexpressed in various types of cancer and directly activates transcription of HOXA1 through demethylation of histone H3K9 by binding to its promoter region
MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene.
GeneRIF
Tanaka et al., Fukuoka, Japan. In Ann Surg Oncol, 2012
Loss of HOXA1 is associated with pancreatic cancer.
HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis.
GeneRIF
Coletta et al., Piracicaba, Brazil. In Bmc Cancer, 2011
HOXA1 may contribute to oral carcinogenesis by increasing tumor cell proliferation, and suggest that HOXA1 expression might be helpful as a prognostic marker for patients with oral squamous cell carcinoma.
The Pbx interaction motif of Hoxa1 is essential for its oncogenic activity.
GeneRIF
Rezsohazy et al., Louvain-la-Neuve, Belgium. In Plos One, 2010
the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1
An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders.
GeneRIF
Miao et al., Wuhan, China. In Plos One, 2010
HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk
Integrated gene networks in breast cancer development.
Review
Kraljevic Pavelic et al., Rijeka, Croatia. In Funct Integr Genomics, 2010
Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
Oculomotility disorders arising from disruptions in brainstem motor neuron development.
Review
Engle, Boston, United States. In Arch Neurol, 2007
This review highlights the clinical features and genetic etiology of 3 congenital cranial dysinnervation disorders: the human homeobox A1 (HOXA1) syndromes, in which early motoneuron development is disrupted; horizontal gaze palsy with progressive scoliosis, in which there is aberrant axonal targeting onto abducens motoneurons; and congenital fibrosis of the extraocular muscles type 1, in which there is aberrant axonal targeting onto the extraocular muscles.
The genetic basis of complex strabismus.
Review
Engle, Boston, United States. In Pediatr Res, 2006
We are discovering that these disorders result from mutations in genes necessary for the normal development and connectivity of brainstem ocular motoneurons, including PHOX2A, SALL4, KIF21A, ROBO3, and HOXA1, and we now refer to these syndromes as the "congenital cranial dysinnervation disorders," or CCDD.
Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development.
Impact
GeneRIF
Engle et al., Boston, United States. In Nat Genet, 2005
Mutations in HOXA1 resulting in abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and autism spectrum disorder were identified.
Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss.
Impact
Schroeder et al., San Diego, United States. In Science, 1998
Deletion of the Arabidopsis farnesyltransferase gene ERA1 or application of farnesyltransferase inhibitors resulted in ABA hypersensitivity of guard cell anion-channel activation and of stomatal closing.
A protein farnesyl transferase involved in abscisic acid signal transduction in Arabidopsis.
Impact
McCourt et al., Toronto, Canada. In Science, 1996
A collection of mutations, designated era, in Arabidopsis thaliana that confer an enhanced response to exogenous ABA includes mutations in the Era1 gene, which encodes the beta subunit of a protein farnesyl transferase.
Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression.
Impact
Chambon et al., Strasbourg, France. In Cell, 1991
The Hox-1.6 gene disrupted in embryonic stem cells by homologous recombination was introduced into the mouse germline.
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