A genetic framework for H2O2 induced cell death in Arabidopsis thaliana.
Helsinki, Finland. In Bmc Genomics, 2014
Several transcription factors (AS1, MYB30, MYC2, WRKY70), cell death regulators (RCD1, DND1) and hormone regulators (AXR1, ERA1, SID2, EDS1, SGT1b) were essential for execution of cell death in cat2.
Integrated gene networks in breast cancer development.
Rijeka, Croatia. In Funct Integr Genomics, 2010
Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
Oculomotility disorders arising from disruptions in brainstem motor neuron development.
Boston, United States. In Arch Neurol, 2007
This review highlights the clinical features and genetic etiology of 3 congenital cranial dysinnervation disorders: the human homeobox A1 (HOXA1) syndromes, in which early motoneuron development is disrupted; horizontal gaze palsy with progressive scoliosis, in which there is aberrant axonal targeting onto abducens motoneurons; and congenital fibrosis of the extraocular muscles type 1, in which there is aberrant axonal targeting onto the extraocular muscles.
The genetic basis of complex strabismus.
Boston, United States. In Pediatr Res, 2006
We are discovering that these disorders result from mutations in genes necessary for the normal development and connectivity of brainstem ocular motoneurons, including PHOX2A, SALL4, KIF21A, ROBO3, and HOXA1, and we now refer to these syndromes as the "congenital cranial dysinnervation disorders," or CCDD.