gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-cell leukemia homeobox 3

HOX11L2, TLX3, Rnx
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HOX11, CAN, CK7, HAD, FATE
Papers on HOX11L2
Deregulation of miR-93 and miR-143 in human esophageal cancer.
New
Mohammadi Roushandeh et al., Hamadān, Iran. In Tumour Biol, Nov 2015
In this study, total RNA was extracted from 30 tumor tissues and 30 nontumor tissues of esophageal tumor margins, using RNX-plus solution.
Compared With Radical Nephrectomy, Nephron-sparing Partial Nephrectomy Protects Apolipoprotein E-deficient Mice From Atherosclerosis Progression.
New
Petrushevska et al., Скопје, Macedonia. In Urology, May 2015
METHODS: Male apoE(-/-) mice were randomly assigned to the following 3 groups: (1) radical left nephrectomy (RNX, 15 mice), (2) partial left nephrectomy (PNX, 15 mice), and (3) left kidney sham operation (sham-op, 12 mice).
Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance.
New
Rohrer et al., Frankfurt am Main, Germany. In Dev Biol, May 2015
A differential function of Dicer1 signaling for the development of embryonic noradrenergic and cholinergic sympathetic neurons is demonstrated by the selective increase in the expression of Tlx3 and the cholinergic marker genes VAChT and ChAT at E16.5.
Prediction of DNA binding motifs from 3D models of transcription factors; identifying TLX3 regulated genes.
Fiser et al., United States. In Nucleic Acids Res, 2015
As an illustration, the predicted DNA binding site for the poorly characterized T-cell leukemia homeobox 3 (TLX3) TF was confirmed with gel shift assay experiments.
Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.
Hashino et al., Sapporo, Japan. In Plos One, 2014
The homeodomain transcription factor, T-cell leukemia 3 (Tlx3), functions as the master neuronal fate regulator by instructively promoting the specification of glutamatergic excitatory neurons and suppressing the specification of gamma-aminobutyric acid (GABAergic) neurons.
The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review.
Review
Xie et al., Shanghai, China. In Tumour Biol, 2014
Whether TLX3 is a predictor of prognosis of pediatric T cell acute lymphocytic leukemia (T-ALL) is controversial, with some studies concluding that it is and others concluding the opposite.
Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.
GeneRIF
Ma et al., Boston, United States. In J Neurosci, 2012
This study demonistrated that Tlx3 and Runx1 act in combination to coordinate the development of nociceptors, thermoceptors, and pruriceptors.
Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
GeneRIF
Cheng et al., Shanghai, China. In J Neurosci, 2012
Tlx1/3 and Ptf1a, the key transcription factors for fate determination of glutamatergic and GABAergic neurons in the dorsal spinal cord
TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.
Impact
GeneRIF
Asnafi et al., France. In Cancer Cell, 2012
The cortical thymic maturation arrest in T-lineage Acute lymphoblastic leukemias (ALLs) that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1.
Hijacking T cell differentiation: new insights in TLX function in T-ALL.
Impact
Aifantis et al., New York City, United States. In Cancer Cell, 2012
TLX1 and TLX3 are two closely-related homeobox transcriptional repressors frequently misexpressed and translocated in T cell acute lymphoblastic leukemia (T-ALL).
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.
Impact
GeneRIF
Ferrando et al., New York City, United States. In Nat Med, 2012
these results place TLX1 and TLX3 at the top of an oncogenic transcriptional network controlling leukemia development, and identify RUNX1 as a tumor-suppressor gene in T-ALL
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Impact
Barata et al., Campinas, Brazil. In Nat Genet, 2011
IL7R mutations induce a gene expression profile partially resembling that provoked by IL-7 and are enriched in the T-ALL subgroup comprising TLX3 rearranged and HOXA deregulated cases.
Aberrant DNA methylation of T-cell leukemia, homeobox 3 modulates cisplatin sensitivity in bladder cancer.
GeneRIF
Naito et al., Fukuoka, Japan. In Int J Oncol, 2011
We found that 22 (21%) out of 110 clinical samples of bladder cancer showed the methylated pattern using the COBRA assay in TLX3. We found a correlation between TLX3 methylation and the sensitivity to cisplatin in the clinical samples by SDI test.
Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia.
Review
Meijerink, Rotterdam, Netherlands. In Best Pract Res Clin Haematol, 2010
Mutually exclusive oncogenic rearrangements may delineate specific T-cell acute lymphoblastic leukaemia (T-ALL) subgroups, and so far at least 4 molecular-cytogenetic subgroups have been identified, i.e. the TAL/LMO, the TLX1/HOX11, the TLX3/HOX11L2 and the HOXA subgroups.
ABL1 rearrangements in T-cell acute lymphoblastic leukemia.
Review
Graux et al., Leuven, Belgium. In Genes Chromosomes Cancer, 2010
The ABL1 fusion is a late event associated with other genetic alterations like NOTCH1 activating mutation, deletion of CDKN2A locus, and ectopic expression of TLX1 or TLX3.
PHF6 mutations in T-cell acute lymphoblastic leukemia.
Impact
Ferrando et al., New York City, United States. In Nat Genet, 2010
Mutational loss of PHF6 is importantly associated with leukemias driven by aberrant expression of the homeobox transcription factor oncogenes TLX1 and TLX3.
Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies.
Review
Speleman et al., Gent, Belgium. In Verh K Acad Geneeskd Belg, 2006
We contributed to an extensive analysis of the phenotypical and prognostic features of T-ALL characterized by HOX11L2 expression and identified HOX11L2 overexpression as one of the most frequent genetic defects in childhood T-ALL, associated with intermediate prognosis.
"Promoter array" studies identify cohorts of genes directly regulated by methylation, copy number change, or transcription factor binding in human cancer cells.
Review
Mercola et al., San Diego, United States. In Ann N Y Acad Sci, 2005
The vast majority of genes that appear to be both differentially methylated and differentially regulated between prostate epithelial and cancer cell lines are novel methylation targets, including PAK6, RAD50, TLX3, PIR51, MAP2K5, INSR, FBN1, GG2-1, representing a rich new source of candidate genes to study the role of DNA methylation in prostate tumors.
share on facebooktweetadd +1mail to friends