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proteins. Page last changed on 08 Dec 2016.
T-cell leukemia homeobox 2
HOX11L1, TLX2, Ncx, Hox11L.1
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010] (from
Hatano et al., Chiba, Japan. In J Pediatr Surg, 2007
Ncx participates in normal developmental cell death of enteric neurons. Ncx may modulate, if not directly target, expression of the caspase-3 at the transcriptional level to participate in neuronal cell death in the enteric nervous system.