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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

T-cell leukemia homeobox 2

HOX11L1, TLX2, Ncx, Hox11L.1
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010] (from NCBI)
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Papers on HOX11L1
Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.
GeneRIF
Goldhaber et al., Los Angeles, United States. In Biophys J, 2010
These results suggest that high subsarcolemmal Ca2+ is required to ensure synchronous triggering with short spark latency in the absence of NCX.
Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.
GeneRIF
Akerman et al., Helsinki, Finland. In Cell Calcium, 2010
NCX-TRPC channel interaction constitutes an important functional unit in receptor-mediated divalent calcium ion influx in neuronal cells.
Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes.
GeneRIF
Li et al., Davis, United States. In Stem Cells Dev, 2010
NCX is functionally expressed in developing ventricular human embryonic stem cell-derived ventricular cardiomyocytes and contributes to their excitation-contraction coupling.
Functional characterization of a minimal sequence essential for the expression of human TLX2 gene.
GeneRIF
Ceccherini et al., Genova, Italy. In Bmb Rep, 2010
TLX2 is an orphan homeodomain transcription factor whose expression is mainly associated with tissues derived from neural crest cells.
Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.
GeneRIF
Hatano et al., Chiba, Japan. In J Pediatr Surg, 2007
Ncx participates in normal developmental cell death of enteric neurons. Ncx may modulate, if not directly target, expression of the caspase-3 at the transcriptional level to participate in neuronal cell death in the enteric nervous system.
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