Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches.
Hong Kong, Hong Kong. In Microb Pathog, Jan 2016
We identified 25 Synergistetes oral cluster A OTUs (genus Fretibacterium; corresponding to Human Oral Taxon (HOT) numbers 358, 359, 360, 361, 362, 363, 452, and 453), and one oral cluster B OTU (Pyramidobacter piscolens oral taxon SH04, HOT-357).
Recent Clinical Trials of Pharmacologic Cardiovascular Interventions in Patients with Chronic Kidney Disease: An Update.
Gold Coast, Australia. In Rev Recent Clin Trials, Nov 2015
Interventions discussed include erythropoiesis-stimulating agents (TREAT, U.S. Normal Hematocrit, CHOIR, CREATE, Palmer meta-analysis); statins (SHARP, AURORA, PPP, 4D, ALERT); fibrates (VA-HIT); folic acid (ASFAST, US FOLIC acid trial, HOST); antihypertensive agents, including angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, beta-blockers and combination therapy (Cice et al, FOSDIAL, Agarwal et al, ONTARGET); sevelamer (DCOR); cinacalcet (ADVANCE, EVOLVE, Cunningham meta-analysis); anti-oxidants (SPACE, HOPE, ATIC); aspirin (HOT study re-analysis); vitamin D analogues (PRIMO); and multidisciplinary intervention (LANDMARK).
Degeneracy as a substrate for respiratory regulation.
Louisville, United States. In Respir Physiol Neurobiol, 2010
Homeostatic systems displaying highly optimized tolerance (HOT) mitigate the instability accompanying high gain by incorporating regulatory mechanisms that provide protection against expected perturbations, yet these systems remain fragile to catastrophic failure in response to rare events.