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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Alcohol dehydrogenase, iron containing, 1

HOT
The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, Angiotensin II, HAD, AGE
Papers on HOT
The Microbiome in Populations with a Low and High Prevalence of Caries.
New
Tanner et al., Umeå, Sweden. In J Dent Res, Jan 2016
Sequences obtained blasted to 9 phyla, 66 genera, and 401 human oral taxa (HOT) in the 16S rRNA Human Oral Microbiome Database, of which 295 were represented by ≥20 sequences.
Distributions of Synergistetes in clinically-healthy and diseased periodontal and peri-implant niches.
New
Watt et al., Hong Kong, Hong Kong. In Microb Pathog, Jan 2016
We identified 25 Synergistetes oral cluster A OTUs (genus Fretibacterium; corresponding to Human Oral Taxon (HOT) numbers 358, 359, 360, 361, 362, 363, 452, and 453), and one oral cluster B OTU (Pyramidobacter piscolens oral taxon SH04, HOT-357).
Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila.
New
Celniker et al., Berkeley, United States. In Genome Res, Nov 2015
We identified "high occupancy target" (HOT) RNAs that interact with the majority of the RBPs we surveyed.
Recent Clinical Trials of Pharmacologic Cardiovascular Interventions in Patients with Chronic Kidney Disease: An Update.
New
Johnson et al., Gold Coast, Australia. In Rev Recent Clin Trials, Nov 2015
Interventions discussed include erythropoiesis-stimulating agents (TREAT, U.S. Normal Hematocrit, CHOIR, CREATE, Palmer meta-analysis); statins (SHARP, AURORA, PPP, 4D, ALERT); fibrates (VA-HIT); folic acid (ASFAST, US FOLIC acid trial, HOST); antihypertensive agents, including angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, beta-blockers and combination therapy (Cice et al, FOSDIAL, Agarwal et al, ONTARGET); sevelamer (DCOR); cinacalcet (ADVANCE, EVOLVE, Cunningham meta-analysis); anti-oxidants (SPACE, HOPE, ATIC); aspirin (HOT study re-analysis); vitamin D analogues (PRIMO); and multidisciplinary intervention (LANDMARK).
Effects of nocturnal oxygen therapy on heart function in SDB patients undergoing dialysis.
New
Fukunaga et al., Moriguchi, Japan. In Ren Fail, Jun 2015
We performed home oxygen therapy (HOT) in patients with SAS undergoing dialysis, and investigated its effects on the heart function.
Improved energy bound accuracy enhances the efficiency of continuous protein design.
New
Donald et al., Durham, United States. In Proteins, Jun 2015
We present two methods, PartCR and HOT, that greatly increase the speed and efficiency of protein design with continuous rotamers.
Therapeutic Potential of microRNA Modulation in Pulmonary Arterial Hypertension.
Review
Bonnet et al., Québec, Canada. In Curr Vasc Pharmacol, 2014
During the last couple of years, the number of studies on the role of microRNA in PAH has broadened, defining it clearly as a HOT TOPIC.
Multiple Days of Heat Exposure on Firefighters' Work Performance and Physiology.
Aisbett et al., Melbourne, Australia. In Plos One, 2014
Firefighters (n = 36) were matched and allocated to either the CON (19°C) or HOT (33°C) condition.
Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease.
Mori et al., Toyonaka, Japan. In Int J Chron Obstruct Pulmon Dis, 2014
A prospective observational study included patients with COPD receiving home oxygen therapy (HOT) between April 1995 and March 2007 to compare the survival rates of the control group (n=47; M:F ratio =34:13; mean age: 71.3±10.0
Upper gastrointestinal complications induced by anti-platelet agents.
Moriyasu et al., Tokyo, Japan. In Clin J Gastroenterol, 2013
The incidence of GI bleeding in aspirin study groups was 0.82 % in the hypertension optimal treatment (HOT) study and 0.76 % in the primary prevention project (PPP) study.
Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network.
Review
Vanoni et al., Milano, Italy. In Biotechnol Adv, 2012
The backbone of the Growth & Cycle network is composed of middle-degree nodes suggesting that it shares some properties with HOT networks.
Degeneracy as a substrate for respiratory regulation.
Review
Mellen, Louisville, United States. In Respir Physiol Neurobiol, 2010
Homeostatic systems displaying highly optimized tolerance (HOT) mitigate the instability accompanying high gain by incorporating regulatory mechanisms that provide protection against expected perturbations, yet these systems remain fragile to catastrophic failure in response to rare events.
Verprolin: a cool set of actin-binding sites and some very HOT prolines.
Review
Thanabalu et al., Griffith, Australia. In Iubmb Life, 2009
Spatiotemporal organisation of eukaryotic cells is established and maintained by the cytoskeleton, a highly dynamic and complex network of structural and signalling proteins.
Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1.
GeneRIF
Ellis et al., Glasgow, United Kingdom. In Chem Biol Interact, 2009
show that the ADHFe1 gene is related to bacterial GHB dehydrogenases and has a conserved NAD-binding site
Blood pressure control, risk factors and cardiovascular prognosis in patients with diabetes: 30 years of progress.
Review
Le Jeune et al., Bobigny, France. In J Hypertens Suppl, 2008
In the HOT study, the addition of aspirin to patients with diabetes and controlled hypertension decreased the risk of myocardial infarction.
Differentiation-dependent expression of Adhfe1 in adipogenesis.
GeneRIF
Smas et al., Toledo, United States. In Arch Biochem Biophys, 2007
Adhfe1 is a novel alcohol dehydrogenase with mitochondrial localization
Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1).
GeneRIF
Mao et al., Shanghai, China. In Dna Seq, 2002
cloned and characterized an iron-activated alcohol dehydrogenase gene, Fe-containing alcohol dehydrogenase 1 (ADHFe1)
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells.
Impact
Modrich et al., Durham, United States. In Science, 1995
Because HOT-15 cells appear to be free of hMSH2 mutations, this selective repair defect is likely a result of a deficiency of the hMutS alpha 160-kilodalton subunit, and mutations in the corresponding gene may confer hypermutability and cancer predisposition.
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