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Host cell factor C1

Host Cell Factor C1, HCF, host cell factor, HCF-1
This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, Oct-1, OCT
Papers using Host Cell Factor C1 antibodies
The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability.
Supplier
Corominas Montserrat et al., In Genome Biology, 1997
... HCF transgenic flies, full-length ...
Papers on Host Cell Factor C1
Characterization of Inhibitor of Differentiation (Id) Proteins in Human Cornea.
New
Rieger et al., Columbia, United States. In Exp Eye Res, Jan 2016
Primary cultures of human corneal fibroblasts (HCF) were established and treated with either TGFβ1 (5 ng/ml) or BMP7 (10 ng/ml) for 24 hrs in serum free medium.
Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?
New
Legler et al., Amsterdam, Netherlands. In Int J Obes (lond), Dec 2015
OBJECTIVES: To determine the effects of altered circadian rhythms on adipogenesis and to better understand how circadian and adipogenic regulatory pathways are linked, zebrafish larvae were exposed to various light/dark cycles or hypercaloric feeding (HCF).
Molecular mechanism of fluoroquinolones modulation on corneal fibroblast motility.
New
Chang et al., Taipei, Taiwan. In Exp Eye Res, Dec 2015
Effect of CIP, LEV, or MOX on HCF migration was monitored using migration assay.
The making of a sweet modification: structure and function of O-GlcNAc transferase.
Review
Walker et al., Boston, United States. In J Biol Chem, 2015
An unexpected second function for O-GlcNAc transferase as a protease involved in cleaving the epigenetic regulator HCF-1 has also been reported.
Expression and localization of Luman/CREB3 in mouse embryos during the pre-implantation period.
Jin et al., Sedan, France. In Genet Mol Res, 2014
This protein interacts with host cell factor 1, which also associates with the herpes simplex virus protein VP16 to induce the transcription of herpes simplex virus.
PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival.
Green et al., Columbus, United States. In Viruses, 2014
Our study provides evidence for PRMT5 as a host cell factor important in HTLV-1-mediated T-cell transformation, and a potential target for ATLL treatment.
The potential role of O-GlcNAc modification in cancer epigenetics.
Review
Krześlak et al., Łódź, Poland. In Cell Mol Biol Lett, 2014
OGT can link the cellular metabolic state and the epigenetic status of cancer cells by interacting with and modifying many epigenetic factors, such as HCF-1, TET, mSin3A, HDAC, and BAP1.
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Impact
Walker et al., Boston, United States. In Science, 2014
Host cell factor-1 (HCF-1), a transcriptional co-regulator of human cell-cycle progression, undergoes proteolytic maturation in which any of six repeated sequences is cleaved by the nutrient-responsive glycosyltransferase, O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT).
The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.
Review
Kristie et al., Bethesda, United States. In Viruses, 2013
Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1).
The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics.
Review
Dey et al., New York City, United States. In Leukemia, 2013
BAP1 functions through effects on stability of host cell factor-1, and O-GlcNAcylation, and ASXL1 impacts histone post-translational modifications through interaction with PRC2.
Loss of the tumor suppressor BAP1 causes myeloid transformation.
Impact
Dixit et al., San Francisco, United States. In Science, 2012
Knockin mice expressing BAP1 with a 3xFlag tag revealed that BAP1 interacts with host cell factor-1 (HCF-1), O-linked N-acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL1 and ASXL2 in vivo.
O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability.
Impact
Yang et al., New Haven, United States. In Cell Metab, 2012
Using a proteomic approach, we identified a broad variety of proteins associated with O-GlcNAc transferase (OGT), among which host cell factor C1 (HCF-1) is highly abundant.
Role of host cell factor-1 in cell cycle regulation.
Review
Tyagi et al., Hyderābād, India. In Transcription, 2012
Host cell factor-1(HCF-1) was first discovered as a cellular cofactor in the VP16-induced complex, a multi-protein DNA complex that forms on immediate early gene promoters of herpes simplex virus (HSV) to activate viral gene transcription.
BAP1 loss defines a new class of renal cell carcinoma.
Impact
Brugarolas et al., Dallas, United States. In Nat Genet, 2012
BAP1 cofractionates with and binds to HCF-1 in tumorgrafts.
A transcriptional regulatory role of the THAP11-HCF-1 complex in colon cancer cell function.
GeneRIF
Chakravarti et al., Chicago, United States. In Mol Cell Biol, 2012
THAP11 was found to associate physically with the transcriptional coregulator HCF-1 (host cell factor 1) and recruit HCF-1 to target promoters
An emerging model for BAP1's role in regulating cell cycle progression.
Review
GeneRIF
Wilkinson et al., Atlanta, United States. In Cell Biochem Biophys, 2011
Studies suggest that BAP1 influences cell proliferation at G1/S by co-regulating transcription from HCF-1/E2F-governed promoters.
O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1.
Impact
GeneRIF
Herr et al., Lausanne, Switzerland. In Cell, 2011
These results reveal an unexpected role of OGT in HCF-1 proteolytic maturation and an unforeseen nexus between OGT-directed O-GlcNAcylation and proteolytic maturation in HCF-1 cell-cycle regulation.
Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth.
GeneRIF
Gallant et al., Zürich, Switzerland. In J Biol Chem, 2011
down-regulation of dHCF-associated histone acetyltransferase and histone methyltransferase complexes in vivo interferes with the Myc biological activities.
Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators.
GeneRIF
Herr et al., Lausanne, Switzerland. In Plos One, 2010
dHCF possesses Enhancer of TrxG and PcG (ETP) properties.
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