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T-box 5

HOS, Tbx5
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, Nkx2.5
Papers using HOS antibodies
Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat
Yoshihara Yoshihiro et al., In Neural Systems & Circuits, 2002
... Double immunofluorescence labelling of OB coronal sections from Tbx5.0gV transgenic mice [line #3(2)] at ...
Papers on HOS
Regulatory modulation of the T-box gene Tbx5 links development, evolution, and adaptation of the sternum.
Logan et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 02 Jan 2015
We demonstrate an essential role for the T-box transcription factor gene Tbx5 in sternum and forelimb formation and show that both structures share an embryological origin within the lateral plate mesoderm.
Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression.
Ye et al., Hangzhou, China. In Int Immunopharmacol, 20 Dec 2014
In this study, we show that piperine inhibited the growth of HOS and U2OS cells in dose- and time-dependent manners but had a weaker effect on the growth of normal hFOB cells.
Polymorphisms Near TBX5 and GDF7 are Associated with Increased Risk for Barrett's Esophagus.
Jankowski et al., In Gastroenterology, 05 Dec 2014
The closest protein-coding genes were GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development.
Biology of upper-body and lower-body adipose tissue-link to whole-body phenotypes.
Pinnick et al., Oxford, United Kingdom. In Nat Rev Endocrinol, 04 Dec 2014
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Holt-Oram syndrome: A case report.
de Jesus et al., Faro, Portugal. In Rev Port Cardiol, 30 Nov 2014
It is a rare autosomal dominant disorder, caused by a mutation in the TBX5 gene located on chromosome 12, but sporadic cases have also been reported.
Iron-salophen complexes involving azole-derived ligands: A new group of compounds with high-level and broad-spectrum in vitro antitumor activity.
Trávníček et al., Olomouc, Czech Republic. In J Inorg Biochem, 25 Nov 2014
The complexes were evaluated for their in vitro antitumor activity against the panel of six human cancer cell lines (HOS, MCF7, A549, HeLa, A2780 and G-361) and were found to be highly cytotoxic, showing the best IC50 value of 58nM for [Fe(III)(salph)(L6)] (6) against the ovarian carcinoma A2780 cell line, being 200-times more effective than cisplatin.
Gibbon genome and the fast karyotype evolution of small apes.
Gibbs et al., Portland, United States. In Nature, Oct 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.
Bultman et al., Chapel Hill, United States. In Cardiovasc Pathol, Mar 2014
Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5.
Heme oxygenation and the widening paradigm of heme degradation.
Heinzl et al., Baltimore, United States. In Arch Biochem Biophys, Mar 2014
However, whereas the P450s promote cleavage of the ferric hydroperoxide OO bond to the oxoferryl species the HOs stabilize the ferric hydroperoxide promoting hydroxylation at the heme edge.
Role of iron in lung injury-induced by hyperoxia.
Liu et al., In Undersea Hyperb Med, Jan 2014
As a rate-limiting enzyme in the degradation of heme, heme oxygenases (HOs) play a crucial role in the iron metabolism.
Effects of diabetes on the eye.
Lutty, Baltimore, United States. In Invest Ophthalmol Vis Sci, Dec 2013
Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy.
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Bassel-Duby et al., Dallas, United States. In Nat Rev Mol Cell Biol, Aug 2013
Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity.
Blending hippo and WNT: sharing messengers and regulation.
Waterman et al., Irvine, United States. In Cell, 2013
show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Hahn et al., Boston, United States. In Cell, 2013
Specifically, we found that YAP1 and the transcription factor TBX5 form a complex with β-catenin.
Hox genes regulate the onset of Tbx5 expression in the forelimb.
Logan et al., London, United Kingdom. In Development, 2012
Hox genes act upstream of Tbx5 to control the axial position of forelimb formation.
Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects.
Yan et al., Jining, China. In Transl Res, 2012
data will not only deepen our understanding of genetic causes of CHD but also provide insight into designing novel personalized therapy for adult patients with CHD by upregulating TBX5 gene expression with different approache
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Moskowitz et al., Chicago, United States. In Dev Cell, 2012
Tbx5 regulated second heart field Gas1 and Osr1 expression, supporting both pathways.
TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Moskowitz et al., Chicago, United States. In J Clin Invest, 2012
a TBX5-responsive enhancer downstream of Scn5a is sufficient to drive ventricular conduction system expression in vivo, dependent on canonical T-box binding sites
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
Wu et al., Boston, United States. In Circ Res, 2012
Induction of Gata4/Mef2c/Tbx5 overexpression in fibroblasts is inefficient at inducing molecular and electrophysiological phenotypes of mature cardiomyocytes.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Olson et al., Dallas, United States. In Nature, 2012
Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro.
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