GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
T-box 5
HOS, Tbx5
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
HOS
antibodies
Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat
Supplier
In Neural Systems & Circuits, 2002
... Double immunofluorescence labelling of OB coronal sections from Tbx5.0gV transgenic mice [line #3(2)] at ...
Papers on
HOS
Guideline-recommended medications: variation across medicare advantage plans and associated mortality.
New
New Bedford, United States. In J Manag Care Pharm, 31 Mar 2013
We linked data from the Medicare Health Outcomes (HOS) Survey cohort 9 (April 2006-May 2008) with the Medicare Part D prescription benefit files (January 1, 2006-December 31, 2007) to examine variation in treatment across MA plans and its association with differences in observed (O)/expected (E) mortality ratio for 5 high-volume chronic conditions: diabetes, coronary artery disease (CAD), congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD)/asthma, and depression.
Zebrafish tbx5 paralogs demonstrate independent essential requirements in cardiac and pectoral fin development.
New
Fort Collins, United States. In Dev Dyn, 26 Mar 2013
Homozygous mutation of tbx5 leads to embryonic lethal cardiac phenotypes and forelimb malformations in vertebrate models.
The Combination of Sorafenib and Everolimus abrogates mTORC-1 and mTORC2 up-regulation in preclinical models of Osteosarcoma.
New
Torino, Italy. In Clin Cancer Res, 22 Mar 2013
Cell viability, colony growth, and cell migration were evaluated in different osteosarcoma cell lines (MNNG-HOS, HOS, KHOS/NP, MG63, U-2OS, SJSA-1, SAOS-2) after scalar dose treatment with sorafenib (10-0.625 muM), rapamycin-analog everolimus (100-6.25 nM), and combinations of the two.
Alleviating Anastrozole induced bone toxicity by selenium nanoparticles in SD Rats.
New
India. In Toxicol Appl Pharmacol, 13 Mar 2013
Selenium nanoparticles at a dose of 5μg/ml significantly reduced the cell death caused by anastrozole (1μM) in HOS (human osteoblast) cells.
β-catenin-Driven Tumors Are Dependent on a YAP1 Transcriptional Complex.
New
In Cancer Discov, 28 Feb 2013
A complex of β-catenin, YAP1, and TBX5 promotes transformation and cancer cell survival.
Blending hippo and WNT: sharing messengers and regulation.
New
Impact
Irvine, United States. In Cell, Jan 2013
show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
New
Impact
Boston, United States. In Cell, Jan 2013
Specifically, we found that YAP1 and the transcription factor TBX5 form a complex with β-catenin.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
New
Impact
Dallas, United States. In Nature, Jul 2012
Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro.
Cardiac natriuretic peptides: from basic discovery to clinical practice.
Review
Ottawa, Canada. In Cardiovasc Ther, 2011
Among the most studied are the transcription factors GATA4, TBX5, and NKX2-5, which are central to cardiac development and mutations of which are associated with congenital heart disease.
Alternative splicing of T-box transcription factor genes.
Review
Birmingham, United States. In Biochem Biophys Res Commun, 2011
Currently, TBX3, TBX5, and TBX20 are TBX genes defined to have multiple protein isoforms created by alternative splicing and characterized by expression and functional studies.
Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer.
Review
Nantes, France. In Immunotherapy, 2011
Heme oxygenases (HOs) are the rate-limiting intracellular enzymes that degrade heme into carbon monoxide (CO), biliverdin and free divalent iron.
Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities.
Review
Ch'unch'ŏn, South Korea. In Antioxid Redox Signal, 2011
Heme oxygenases (HOs) are the rate-limiting enzymes in the catabolism of heme into biliverdin, free iron, and carbon monoxide.
Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer.
GeneRIF
Hong Kong, Hong Kong. In Oncogene, 2011
a novel functional tumor suppressor gene TBX5 inactivated by promoter methylation in colon cancer was identified. Detection of methylated TBX5 may serve as a potential biomarker for the prognosis of this malignancy.
Synergistic activation of cardiac genes by myocardin and Tbx5.
GeneRIF
Chapel Hill, United States. In Plos One, 2010
the interaction of myocardin and Tbx5 maybe involved in cardiac development and diseases
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.
GeneRIF
Montréal, Canada. In Proc Natl Acad Sci U S A, 2010
Nos3, a gene regulated by many congenital heart disease risk factors including stress and diabetes, interacts genetically with Tbx5 provides a molecular framework to understand gene-environment interaction in the setting of human birth defects.
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells.
GeneRIF
New York City, United States. In J Biol Chem, 2010
Stat3 is required for the differentiation of cardiomyocytes through direct transcriptional regulation of Tbx5, Nkx2.5, and GATA4
Haem oxygenase (HO): an overlooked enzyme of plant metabolism and defence.
Review
India. In J Exp Bot, 2010
The crystal structure of HO1, a monomeric protein, has been extensively reported in mammals, pathogenic bacteria, and cyanobacteria, but no such reports are available for higher plant HOs except a predicted model for pea HO1.
Genome-wide association study of PR interval.
Impact
München, Germany. In Nat Genet, 2010
Six of the loci were near cardiac developmental genes, including CAV1-CAV2, NKX2-5 (CSX1), SOX5, WNT11, MEIS1, and TBX5-TBX3, providing pathophysiologically interesting candidate genes.
Several common variants modulate heart rate, PR interval and QRS duration.
Impact
Reykjavík, Iceland. In Nat Genet, 2010
We identified one locus for heart rate (MYH6), four for PR interval (TBX5, SCN10A, CAV1 and ARHGAP24) and four for QRS duration (TBX5, SCN10A, 6p21 and 10q21).
Divergent transcriptional activities determine limb identity.
GeneRIF
Montréal, Canada. In Nat Commun, 2009
Data show that Tbx4 and Tbx5 harbour conserved and divergent transcriptional regulatory domains that account for their roles in limb development. In particular, both factors share an activator domain and the ability to stimulate limb growth
