Gibbon genome and the fast karyotype evolution of small apes.
Portland, United States. In Nature, 11 Oct 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.
Chapel Hill, United States. In Cardiovasc Pathol, Mar 2014
Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5.
Effects of diabetes on the eye.
Baltimore, United States. In Invest Ophthalmol Vis Sci, Dec 2013
Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy.
Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents.
Olomouc, Czech Republic. In Plos One, Dec 2013
MCF7 (breast carcinoma), HOS (osteosarcoma), A549 (adenocarcinoma), G361 (melanoma), HeLa (cervical cancer), A2780 (ovarian carcinoma), A2780R (ovarian carcinoma resistant to cisplatin), 22Rv1 (prostate cancer) and THP-1 (monocytic leukaemia), for their in vitro anti-inflammatory activity using a model of LPS-activated macrophages, and for their in vivo antiedematous activity by λ-carrageenan-induced hind paw edema model on rats.