Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Inherited progressive cardiac conduction disorders.
Bern, Switzerland. In Curr Opin Cardiol, 2015
Other genes coding for cardiac transcription factors, such as NKX2.5 and TBX5, are involved in the development of the cardiac conduction system and in the morphogenesis of the heart.
Gibbon genome and the fast karyotype evolution of small apes.
Portland, United States. In Nature, 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.