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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Apr 2015.

T-box 5

HOS, Tbx5
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Nkx2.5
Papers using HOS antibodies
Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat
Supplier
Yoshihara Yoshihiro et al., In Neural Systems & Circuits, 2002
... Double immunofluorescence labelling of OB coronal sections from Tbx5.0gV transgenic mice [line #3(2)] at ...
Papers on HOS
Technical decision making with higher order structure data: higher order structure characterization during protein therapeutic candidate screening.
New
Wen et al., Thousand Oaks, United States. In J Pharm Sci, 30 Apr 2015
Protein therapeutics differ considerably from small molecule drugs because of the presence of higher order structure (HOS), post-translational modifications, inherent molecular heterogeneity, and unique stability profiles.
Characterization of the 12q Amplicons in Lipomatous Soft Tissue Tumors by Multiplex Ligation-dependent Probe Amplification-based Copy Number Analysis.
New
Ferdinande et al., Utrecht, Netherlands. In Anticancer Res, 30 Apr 2015
Moreover, we identified additional genes exclusively amplified in DDLPS in 12q13, 12q21 and 12q24, including glioma-associated oncogene homolog 1 (GLI1), mitogen activated protein kinase kinase kinase 12 (MAP3K12), cyclin-dependent kinase 2 (CDK2), ALX homeobox 1 (ALX1) and T-box 5 (TBX5).
TBX5 loss-of-function mutation contributes to familial dilated cardiomyopathy.
New
Yang et al., Shanghai, China. In Biochem Biophys Res Commun, 27 Apr 2015
The cardiac T-box transcription factor TBX5 is crucial for proper cardiovascular development, and mutations in TBX5 have been associated with various congenital heart diseases and arrhythmias in humans.
ADRA2A is involved in neuro-endocrine regulation of bone resorption.
New
Marc et al., Ljubljana, Slovenia. In J Cell Mol Med, 27 Apr 2015
Functionality of rs553668 and rs1800544 single nucleotide polymorphism SNPs located in α2A-AR gene was analysed by qPCR expression on bone samples and luciferase reporter assay in human osteosarcoma HOS cells.
Targeting the Pro-Survival Protein MET with Tivantinib (ARQ 197) Inhibits Growth of Multiple Myeloma Cells.
New
Gandhi et al., Houston, United States. In Neoplasia, 31 Mar 2015
The hepatocyte growth factor (HGF)/MNNG HOS transforming gene (MET) pathway regulates cell growth, survival, and migration.
Molecular basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications.
Review
New
Al-Shaar et al., Riyadh, Saudi Arabia. In Gene, 10 Mar 2015
UNASSIGNED: This paper reviews the molecular basis of the clinical features of Holt-Oram syndrome resulting from missense and extended protein mutations of the TBX5 gene as well as TBX5 intragenic duplications.
The role of transcription factors in atrial fibrillation.
Review
New
Tu et al., Wuhan, China. In J Thorac Dis, Feb 2015
In this review, we will focus on the potential role of PITX2, PRRX1, ZHFX3, TBX5, and NKX2.5 in AF.
Gibbon genome and the fast karyotype evolution of small apes.
New
Impact
Gibbs et al., Portland, United States. In Nature, Oct 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.
Review
New
Bultman et al., Chapel Hill, United States. In Cardiovasc Pathol, Mar 2014
Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5.
Role of iron in lung injury-induced by hyperoxia.
Review
Liu et al., In Undersea Hyperb Med, 2014
As a rate-limiting enzyme in the degradation of heme, heme oxygenases (HOs) play a crucial role in the iron metabolism.
Effects of diabetes on the eye.
Review
Lutty, Baltimore, United States. In Invest Ophthalmol Vis Sci, 2013
Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy.
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.
Review
Impact
Bassel-Duby et al., Dallas, United States. In Nat Rev Mol Cell Biol, 2013
Heart function has been restored in rodents by reprogramming non-myocytes into cardiomyocytes, by expressing transcription factors (GATA4, HAND2, myocyte-specific enhancer factor 2C (MEF2C) and T-box 5 (TBX5)) and microRNAs (miR-1, miR-133, miR-208 and miR-499) that control cardiomyocyte identity.
Blending hippo and WNT: sharing messengers and regulation.
Impact
Waterman et al., Irvine, United States. In Cell, 2013
show how β-catenin and YAP1 form a kinase-regulated complex with transcription factor TBX5.
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis.
Impact
Hahn et al., Boston, United States. In Cell, 2013
Specifically, we found that YAP1 and the transcription factor TBX5 form a complex with β-catenin.
Hox genes regulate the onset of Tbx5 expression in the forelimb.
GeneRIF
Logan et al., London, United Kingdom. In Development, 2012
Hox genes act upstream of Tbx5 to control the axial position of forelimb formation.
Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects.
GeneRIF
Yan et al., Jining, China. In Transl Res, 2012
data will not only deepen our understanding of genetic causes of CHD but also provide insight into designing novel personalized therapy for adult patients with CHD by upregulating TBX5 gene expression with different approache
Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
GeneRIF
Moskowitz et al., Chicago, United States. In Dev Cell, 2012
Tbx5 regulated second heart field Gas1 and Osr1 expression, supporting both pathways.
TBX5 drives Scn5a expression to regulate cardiac conduction system function.
GeneRIF
Moskowitz et al., Chicago, United States. In J Clin Invest, 2012
a TBX5-responsive enhancer downstream of Scn5a is sufficient to drive ventricular conduction system expression in vivo, dependent on canonical T-box binding sites
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
GeneRIF
Wu et al., Boston, United States. In Circ Res, 2012
Induction of Gata4/Mef2c/Tbx5 overexpression in fibroblasts is inefficient at inducing molecular and electrophysiological phenotypes of mature cardiomyocytes.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Impact
Olson et al., Dallas, United States. In Nature, 2012
Here we show that four transcription factors, GATA4, HAND2, MEF2C and TBX5, can cooperatively reprogram adult mouse tail-tip and cardiac fibroblasts into beating cardiac-like myocytes in vitro.
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