Biology of upper-body and lower-body adipose tissue-link to whole-body phenotypes.
Oxford, United Kingdom. In Nat Rev Endocrinol, 04 Dec 2014
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Holt-Oram syndrome: A case report.
Faro, Portugal. In Rev Port Cardiol, 30 Nov 2014
It is a rare autosomal dominant disorder, caused by a mutation in the TBX5 gene located on chromosome 12, but sporadic cases have also been reported.
Gibbon genome and the fast karyotype evolution of small apes.
Portland, United States. In Nature, Oct 2014
Finally, we identify signatures of positive selection in genes important for forelimb development (TBX5) and connective tissues (COL1A1) that may have been involved in the adaptation of gibbons to their arboreal habitat.
SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.
Chapel Hill, United States. In Cardiovasc Pathol, Mar 2014
Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5.
Effects of diabetes on the eye.
Baltimore, United States. In Invest Ophthalmol Vis Sci, Dec 2013
Gene therapies upregulating MNNG HOS transforming gene (cMet) and/or downregulating MMP10 and cathepsin S are potential future therapies for diabetic keratopathy.