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Lipase, hormone-sensitive

hormone-sensitive lipase, hormone-sensitive lipase,, LIPE
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, fibrillin-1, Perilipin, HAD
Papers on hormone-sensitive lipase
Expression of lipid metabolism-related proteins in breast phyllodes tumors.
Koo et al., In Neoplasma, Feb 2016
Immunohistochemical staining for lipid metabolism-related proteins, namely hormone-sensitive lipase (HSP), perilipin 2, fatty-acid-binding proteins 4 (FABP4), Carnitine palmitoyltransferase-1 (CPT-1), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed, and the immunohistochemical staining results were analyzed with respect to clinicopathologic parameters.
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Sam et al., Boston, United States. In Circ Heart Fail, Jan 2016
In HFpEF, despite a larger brown AT mass (5.96 versus 4.50 mg/g), brown AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-like effector a (cidea), and epithelial V-like antigen (eva) expression and decreased expression of lipolytic enzymes (hormone-sensitive lipase, lipoprotein lipase, and fatty acid binding protein 4) versus sham.
Inhibition by Seeds of Phalaris canariensis Extracts of Key Enzymes Linked to Obesity.
Cruz Victoria et al., In Altern Ther Health Med, Jan 2016
Lipolytic activity in cultured, mouse, 3T3-Ll adipocytes was used as a measure of hormone-sensitive lipase activity.
Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase.
Holm et al., Lund, Sweden. In Cell Signal, Jan 2016
The lipolytic action of PTH was paralleled by phosphorylation of known protein kinase A (PKA) substrates, i.e. hormone-sensitive lipase (HSL) and perilipin.
Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis.
Zhu et al., Guangzhou, China. In Plos One, Dec 2015
In addition, 3T3-L1 adipocytes were treated with AS and the effects on adipogenesis and lipolysis were evaluated by western blot analysis of adipogenic transcription factors and lipid-metabolizing enzyme levels and the phosphorylation status of protein kinase (PK) A and hormone-sensitive lipase (HSL).
Sympathetic neuro-adipose connections mediate leptin-driven lipolysis.
Domingos et al., New York City, United States. In Cell, Oct 2015
Conversely, genetic ablation of sympathetic inputs onto fat pads blocks leptin-stimulated phosphorylation of hormone-sensitive lipase and consequent lipolysis, as do knockouts of dopamine β-hydroxylase, an enzyme required for catecholamine synthesis.
Regulation of exercise-induced lipid metabolism in skeletal muscle.
Kiens et al., Copenhagen, Denmark. In Exp Physiol, 2015
In skeletal muscle, 98% of the lipase activity is accounted for by adipose triglyceride lipase and hormone-sensitive lipase.
The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells.
Kizaki et al., Kami-renjaku, Japan. In J Obes, 2014
Of note, the discovery of a new lipase, known as adipose triglyceride lipase, has redefined the existing concepts of the hormone-sensitive lipase-dependent hydrolysis of TG in white adipocytes.
Fatty acid signaling: the new function of intracellular lipases.
Cahova et al., Praha, Czech Republic. In Int J Mol Sci, 2014
The specific contribution of free fatty acids released by particular lipases, hormone-sensitive lipase, adipose triacylglycerol lipase and lysosomal lipase will also be discussed.
[Hormone-sensitive lipase/cholesteryl esterase from the adrenal cortex - structure, regulation and role in steroid hormone synthesis].
Trzeciak et al., In Postepy Biochem, 2014
Hormone-sensitive lipase/cholesteryl esterase (HSL), encoded by LIPE gene, plays a very important role in the metabolism of acylglycerols in the adipose tissue and cholesteryl esters in the adrenal cortex, gonads and placenta.
Hormone-sensitive lipase deficiency in humans.
Langin et al., Graz, Austria. In Cell Metab, 2014
(2014) demonstrate that the lack of hormone-sensitive lipase, a member of the enzyme trio that catabolizes fat, has pronounced effects on lipid metabolism, glucose homeostasis, and cell signaling in humans.
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Damcott et al., Baltimore, United States. In N Engl J Med, 2014
METHODS: We sequenced 12 lipolytic-pathway genes in Old Order Amish participants whose fasting serum triglyceride levels were at the extremes of the distribution and identified a novel 19-bp frameshift deletion in exon 9 of LIPE, encoding hormone-sensitive lipase (HSL), a key enzyme for lipolysis.
Effects of DHEA on metabolic and endocrine functions of adipose tissue.
Kochan et al., Gdańsk, Poland. In Horm Mol Biol Clin Investig, 2013
Recent studies demonstrate that DHEA stimulates triacylglycerol hydrolysis in adipose tissue by increasing the expression and activity of adipose triglyceride lipase and hormone-sensitive lipase, the key enzymes of lipolysis.
Gut-derived serotonin is a multifunctional determinant to fasting adaptation.
Karsenty et al., New York City, United States. In Cell Metab, 2012
In adipocytes, GDS signals through the Htr2b receptor to favor lipolysis by increasing phosphorylation and activity of hormone-sensitive lipase.
Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages.
Suzuki et al., Tokyo, Japan. In Microb Pathog, 2012
M. leprae suppresses lipid degradation through inhibition of HSL expression.
Enzyme promiscuity in the hormone-sensitive lipase family of proteins.
Luigi et al., Napoli, Italy. In Protein Pept Lett, 2012
Enzyme promiscuity in the hormone-sensitive lipase family of proteins.
Genetic variation of hormone sensitive lipase and male infertility.
Tavilani et al., Hamadān, Iran. In Syst Biol Reprod Med, 2011
suggests that genetic variation of HSL may be a risk factor for male infertility
Adipose triglyceride lipase contributes to cancer-associated cachexia.
Hoefler et al., Graz, Austria. In Science, 2011
total lipase, ATGL and HSL activities were higher in visceral white adipose tissue of cancer patients compared with individuals without cancer and higher in cancer patients with cachexia compared with cancer patients without cachexia
[Effects of the LIPE C-60G polymorphism on changes of plasma lipids and glucose induced by a high-carbohydrate diet in healthy youth].
Fang et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2011
LIPE C-60G variation can inhibit the decrease of LDL-C and the increases of HDL-C and apo A-I in young healthy males, and can inhibit the decrease of LDL-C and the increase of insulin in young healthy females induced by a high-carbohydrate diet.
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