Expression of lipid metabolism-related proteins in breast phyllodes tumors.
In Neoplasma, Feb 2016
Immunohistochemical staining for lipid metabolism-related proteins, namely hormone-sensitive lipase (HSP), perilipin 2, fatty-acid-binding proteins 4 (FABP4), Carnitine palmitoyltransferase-1 (CPT-1), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed, and the immunohistochemical staining results were analyzed with respect to clinicopathologic parameters.
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Boston, United States. In Circ Heart Fail, Jan 2016
In HFpEF, despite a larger brown AT mass (5.96 versus 4.50 mg/g), brown AT showed reduced activity with decreased uncoupling protein 1 (ucp-1), cell death-inducing DFFA-like effector a (cidea), and epithelial V-like antigen (eva) expression and decreased expression of lipolytic enzymes (hormone-sensitive lipase, lipoprotein lipase, and fatty acid binding protein 4) versus sham.
Sympathetic neuro-adipose connections mediate leptin-driven lipolysis.
New York City, United States. In Cell, Oct 2015
Conversely, genetic ablation of sympathetic inputs onto fat pads blocks leptin-stimulated phosphorylation of hormone-sensitive lipase and consequent lipolysis, as do knockouts of dopamine β-hydroxylase, an enzyme required for catecholamine synthesis.
Hormone-sensitive lipase deficiency in humans.
Graz, Austria. In Cell Metab, 2014
(2014) demonstrate that the lack of hormone-sensitive lipase, a member of the enzyme trio that catabolizes fat, has pronounced effects on lipid metabolism, glucose homeostasis, and cell signaling in humans.
Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.
Baltimore, United States. In N Engl J Med, 2014
METHODS: We sequenced 12 lipolytic-pathway genes in Old Order Amish participants whose fasting serum triglyceride levels were at the extremes of the distribution and identified a novel 19-bp frameshift deletion in exon 9 of LIPE, encoding hormone-sensitive lipase (HSL), a key enzyme for lipolysis.