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HORMA domain containing 1

HORMAD1, HORMA domain-containing protein, CT46, Newborn Ovary HORMA protein, Nohma
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Iris, Rad51, SCP3, Mad2, POLYMERASE
Papers on HORMAD1
MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.
New
de Massy et al., Montpellier, France. In J Cell Sci, Jun 2015
Here, we show that HORMAD1, one of the meiotic chromosome axis components, is required for MEI4 localization.
Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.
New
Tutt et al., London, United Kingdom. In Cancer Discov, May 2015
Furthermore, we show that a high level of AiCNA is linked with elevated expression of a meiosis-associated gene, HORMAD1.
Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives.
New
Byrne et al., Los Angeles, United States. In Stem Cells Transl Med, Feb 2015
In the present study, we used correlative gene expression analysis of two putative mouse "immunogenicity" genes, ZG16 and HORMAD1, to assay their human homologous expression levels in human pluripotent stem cells and their derivatives.
The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.
Corbett et al., Berkeley, United States. In Dev Cell, 2014
Finally, we find that mammalian HORMAD1 binds a motif found both at its own C terminus and at that of HORMAD2, indicating that this mode of intermolecular association is a conserved feature of meiotic chromosome structure in eukaryotes.
Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion.
Jessberger et al., Dresden, Germany. In Embo J, 2014
Asynapsis marker HORMAD1 is diffusely distributed throughout the chromatin, and SYCP1, which normally marks synapsed axes, is largely absent.
Potentially immunogenic proteins expressed similarly in human embryonic stem cells and induced pluripotent stem cells.
Firpo et al., Minneapolis, United States. In Exp Biol Med (maywood), 2014
In this study, we examined whether the human homologs of these markers, HORMAD1, ZG16, and Cyp3A, are differentially expressed in human iPS versus ES cells, as well as undifferentiated and in vitro-differentiated cells.
Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers.
Zhao et al., Baltimore, United States. In Cancer Immunol Res, 2014
For example, HORMAD1, CXorf61, ACTL8, and PRAME are highly enriched in the basal subtype of breast cancer; MAGE and CSAG are most frequently activated in the magnoid subtype of lung adenocarcinoma; and PRAME is highly upregulated in the ccB subtype of clear cell renal cell carcinoma.
The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila.
Juhász et al., Budapest, Hungary. In Biomed Res Int, 2013
Another HORMA domain-containing protein, Mad2, forms a conformational homodimer.
Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis.
Rajkovic et al., Pittsburgh, United States. In Biol Reprod, 2013
We previously discovered that HORMAD1 is a critical component of the synaptonemal complex but not essential for oocyte survival.
ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.
Turner et al., London, United Kingdom. In Genes Dev, 2013
ATR first regulates HORMA (Hop1, Rev7, and Mad2) domain protein HORMAD1/2 phosphorylation and localization of breast cancer I (BRCA1) and ATR cofactors ATR-interacting peptide (ATRIP)/topoisomerase 2-binding protein 1 (TOPBP1) at unsynapsed axes.
Biological significance of HORMA domain containing protein 1 (HORMAD1) in epithelial ovarian carcinoma.
Review
Sood et al., Houston, United States. In Cancer Lett, 2013
The present study was undertaken to determine the expression and biological significance of HORMAD1 in human epithelial ovarian carcinoma.
CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline.
Pintard et al., Paris, France. In Plos Genet, 2013
Finally, CRL2(LRR-1) inhibits the first steps of meiotic prophase by targeting in mitotic germ cells degradation of the HORMA domain-containing protein HTP-3, required for loading synaptonemal complex components onto meiotic chromosomes.
HORMAD2/CT46.2, a novel cancer/testis gene, is ectopically expressed in lung cancer tissues.
Sha et al., Nanjing, China. In Mol Hum Reprod, 2012
Recently, it has been shown that ectopic expression of several germ line genes, such as piwi, vasa, nos and aub, drives the growth of malignant brain tumors in Drosophila.
HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes.
GeneRIF
Kurahashi et al., Japan. In Genes Cells, 2012
By the analysis of Hormad1/Spo11 double mutants, the Hormad1 deficiency was found to abrogate the massive oocyte loss in the Spo11-deficient ovary. The Hormad1 deficiency also causes the eventual loss of pseudo sex body in the Spo11-deficient ovary and testis.
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Impact
GeneRIF
Tóth et al., Dresden, Germany. In Nat Cell Biol, 2011
propose that the synaptonemal complex and HORMAD1 are key components of a negative feedback loop that coordinates meiotic progression with homologue alignment: HORMAD1 promotes homologue alignment and synaptonemal-complex formation
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.
GeneRIF
Rajkovic et al., Houston, United States. In Plos Genet, 2010
HORMAD1 is a critical component of the synaptonemal complex that affects synapsis, recombination, and meiotic sex chromosome inactivation and transcriptional silencing.
A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes.
GeneRIF
Höög et al., Stockholm, Sweden. In Exp Cell Res, 2010
Results suggest that also mammalian cells use a HORMA domain-containing protein (HORMAD1) as part of a surveillance system that monitors chromosomal synapsis or other interactions between homologs.
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.
GeneRIF
Toth et al., Dresden, Germany. In Plos Genet, 2009
HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13.
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