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HOP2 Hop2p

Hop2, TBPIP, AHP2
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011] (from NCBI)
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Top mentioned proteins: Dmc1, Rad51, V1a, ACID, PACAP
Papers on Hop2
Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1.
New
Mechtler et al., Vienna, Austria. In J Proteome Res, Jan 2016
The HOP2-MND1 heterodimer is essential for meiotic homologous recombination in plants and other eukaryotes and promotes the repair of DNA double-strand breaks.
Significance of ligand interactions involving Hop2-Mnd1 and the RAD51 and DMC1 recombinases in homologous DNA repair and XX ovarian dysgenesis.
New
Sung et al., New Haven, United States. In Nucleic Acids Res, May 2015
The evolutionarily conserved Hop2-Mnd1 complex is a key cofactor for the meiosis-specific recombinase Dmc1.
Involvement of two-component signalling systems in the regulation of stomatal aperture by light in Arabidopsis thaliana.
Hetherington et al., Bristol, United Kingdom. In New Phytol, 2014
Here, we investigated the roles of TCS genes, the histidine phosphotransferase AHP2 and the histidine kinases AHK2 and AHK3, previously reported to play roles in cytokinin and abscisic acid (ABA) signalling.
The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation.
Bishop et al., Chicago, United States. In J Biol Chem, 2014
During meiosis in Saccharomyces cerevisiae, the HOP2 and MND1 genes are essential for recombination.
Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein.
Pezza et al., Oklahoma City, United States. In J Biol Chem, 2014
The HOP2 protein is required for efficient double-strand break repair which ensures the proper synapsis of homologous chromosomes and normal meiotic progression.
Cytokinin antagonizes abscisic acid-mediated inhibition of cotyledon greening by promoting the degradation of abscisic acid insensitive5 protein in Arabidopsis.
Zuo et al., Beijing, China. In Plant Physiol, 2014
We found that the cytokinin-antagonized ABA effect is dependent on a functional cytokinin signaling pathway, mainly involved in the cytokinin receptor gene cytokinin response1/Arabidopsis histidine kinase4, downstream histidine phosphotransfer protein genes AHP2, AHP3, and AHP5, and a type B response regulator gene, ARR12, which genetically acts upstream of ABI5 to regulate cotyledon greening.
The dual role of HOP2 in mammalian meiotic homologous recombination.
Camerini-Otero et al., Philadelphia, United States. In Nucleic Acids Res, 2014
Deletion of Hop2 in mice eliminates homologous chromosome synapsis and disrupts double-strand break (DSB) repair through homologous recombination.
Local health department planning for a radiological emergency: an application of the AHP2 tool to emergency preparedness prioritization.
Klebesadal et al., Monterey, United States. In Public Health Rep, 2013
METHODS: We developed a dedicated tool called All-Hazards Preparedness Squared (AHP2) that can be used by those who are responsible for all-hazards preparedness planning and response to guide them while making strategic decisions both in preparing for and responding to a slow-moving incident while it is unfolding.
HOP2-MND1 modulates RAD51 binding to nucleotides and DNA.
Mazin et al., Philadelphia, United States. In Nat Commun, 2013
The HOP2-MND1 heterodimer is required for progression of homologous recombination in eukaryotes.
Sufficient amounts of functional HOP2/MND1 complex promote interhomolog DNA repair but are dispensable for intersister DNA repair during meiosis in Arabidopsis.
Grelon et al., Vienna, Austria. In Plant Cell, 2013
The homologous-pairing protein2/meiotic nuclear division protein1 (HOP2/MND1) protein complex has been identified as a crucial factor of meiotic HR in Arabidopsis thaliana, since loss of either MND1 or HOP2 results in failure of DNA repair.
Expression, purification, and characterization of cytokinin signaling intermediates: Arabidopsis histidine phosphotransfer protein 1 (AHP1) and AHP2.
Kumar et al., Singapore, Singapore. In Plant Cell Rep, 2013
KEY MESSAGE: We have expressed, purified, and biophysically characterized recombinant AHP1 and AHP2.
Arabidopsis AHP2, AHP3, and AHP5 histidine phosphotransfer proteins function as redundant negative regulators of drought stress response.
Tran et al., Yokohama, Japan. In Proc Natl Acad Sci U S A, 2013
Here, we report that three Arabidopsis AHPs, namely AHP2, AHP3, and AHP5, control responses to drought stress in negative and redundant manner.
GT198 Splice Variants Display Dominant-Negative Activities and Are Induced by Inactivating Mutations.
Ko et al., Augusta, United States. In Genes Cancer, 2013
The putative tumor suppressor gene GT198 (PSMC3IP), encoding a protein also known as TBPIP and Hop2, has been shown to regulate steroid hormone receptor-mediated transcription and to stimulate homologous recombination in DNA repair.
Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.
Ko et al., Augusta, United States. In Genes Cancer, 2013
The human GT198 gene (gene symbol PSMC3IP) is located at chromosome 17q21, 470 kb proximal to BRCA1, a locus previously linked to breast and ovarian cancer predisposition.
XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription.
GeneRIF
Levy-Lahad et al., Jerusalem, Israel. In Am J Hum Genet, 2011
a PSMC3IP/HOP2 mutation may cause XX ovarian dysgenesis through abolishing coactivation of estrogen-driven transcription
Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2.
GeneRIF
Mori et al., Maebashi, Japan. In Endocrinology, 2009
findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP.
Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.
GeneRIF
Sung et al., New Haven, United States. In Genes Dev, 2007
bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation
Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing.
GeneRIF
Camerini-Otero et al., Bethesda, United States. In Genes Dev, 2007
Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs
Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.
GeneRIF
Gerton et al., Kansas City, United States. In Mol Cell Biol, 2006
HOP2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis.
The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.
Impact
Roeder et al., New Haven, United States. In Cell, 1998
The hop2 mutant of S. cerevisiae displays a novel phenotype: meiotic chromosomes form nearly wild-type amounts of synaptonemal complex, but most chromosomes are engaged in synapsis with nonhomologous partners.
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