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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Homer homolog 1

Homer
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, mGluR
Papers on Homer
Catheter Ablation of Ventricular Tachycardia in the Setting of Known LV Thrombus: Between Scylla and Charybdis?
New
Tedrow et al., Boston, United States. In J Cardiovasc Electrophysiol, Feb 2016
UNASSIGNED: According to Homer, when passing the straits of Messina, the hero Odysseus was forced to make a terrible choice: lose 6 crewmembers' lives at the hands of the terrible six-headed monster, Scylla, or risk all drowning (or surviving) in the inescapable whirlpool created by the underwater beast, Charybdis.
Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology.
New
Saxena et al., Bern, Switzerland. In Neuron, Feb 2016
Focusing on Homer-3, a PC-enriched scaffold protein regulating neuronal activity, revealed an early decline in its expression.
Prefrontal glutamate correlates of methamphetamine sensitization and preference.
New
Szumlinski et al., Santa Barbara, United States. In Eur J Neurosci, Feb 2016
Repeated methamphetamine sensitized drug-induced glutamate release and lowered indices of NMDA receptor expression in C57BL/6J mice, but did not alter basal extracellular glutamate content or total protein expression of Homer proteins, or metabotropic or AMPA glutamate receptors.
Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model.
New
Huber et al., Dallas, United States. In Cell Rep, Jan 2016
Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted scaffolding with its binding partner Homer, contributes to the pathophysiology of fragile X syndrome, a common inherited form of intellectual disability and autism caused by mutations in Fmr1.
Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity.
Review
New
Worley et al., Baltimore, United States. In Brain Res, Jan 2016
For example, dopamine receptor activation modulates corticostriatal plasticity through a mechanism involving the induction of the immediate early gene Homer 1a, the phosphorylation of metabotropic glutamate receptor 5 (mGluR5)'s Homer ligand, and the enhancement of an NMDA receptor-dependent current.
Depolarization of Hippocampal Neurons Induces Formation of Nonsynaptic NMDA Receptor Islands Resembling Nascent Postsynaptic Densities(1,2,3).
New
Reese et al., Bethesda, United States. In Eneuro, Nov 2015
Islands exhibit cytoplasmic dense material resembling that at postsynaptic densities (PSDs), and contain typical PSD components, including MAGUKS (membrane-associated guanylate kinases), GKAP, Shank, Homer, and CaMKII detected by pre-embedding immunogold electron microscopy.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects, and provides a summary and outlook.
'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.
'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook.
Review
Wildemann et al., Heidelberg, Germany. In J Neuroinflammation, 2014
Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-associated autoimmune cerebellar ataxia (ACA); part 2 covers anti-protein kinase C gamma-, anti-glutamate receptor delta-2-, anti-Ca/RhoGTPase-activating protein 26- and anti-voltage-gated calcium channel-associated ACA; and part 3 reviews the current knowledge on anti-Tr/delta notch-like epidermal growth factor-related receptor-, anti-Nb/AP3B2-, anti-Yo/cerebellar degeneration-related protein 2- and Purkinje cell antibody 2-associated ACA, discusses differential diagnostic aspects and provides a summary and outlook.
The Microfloras of Traditional Greek Cheeses.
Review
Tzanetakis et al., In Microbiol Spectr, 2014
In the 8th century BCE, Homer described a cheese thought to be the ancestor of feta, the main cheese manufactured in Greece from the ancient times until today.
Experience-dependent expression of rat hippocampal Arc and Homer 1a after spatial learning on 8-arm and 12-arm radial mazes.
GeneRIF
Habibian et al., Eşfahān, Iran. In Neuroscience, 2012
Significantly elevated expression of both Arc and H1a was observed after spatial learning with differing behavioral task demands
Homer proteins accelerate Ca2+ clearance mediated by the plasma membrane Ca2+ pump in hippocampal neurons.
GeneRIF
Thayer et al., Minneapolis, United States. In Biochem Biophys Res Commun, 2012
PMCA-mediated Ca(2+) clearance may be stimulated following incorporation of the pump into Homer organized signaling domains and following induction of the Homer 1a immediate early gene.
Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways.
GeneRIF
Quirion et al., Montréal, Canada. In Plos One, 2011
A model of successful cognitive aging with a critical role for mGluR5, Homer 1 proteins and downstream signalling pathways is proposed here.
[Homer protein expression after focal brain contusion in rats].
GeneRIF
Wang et al., Shenyang, China. In Fa Yi Xue Za Zhi, 2011
Expression of Homer protein near the focal contusion area shows time dependence after brain contusion in rats.
High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.
GeneRIF
Margulies et al., Boston, United States. In Plos One, 2011
HOMER1 encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR activity, and is a novel autism-risk gene.
A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies.
Impact
Chatterjee et al., In Nat Genet, 2009
Homer et al. recently suggested that a method for forensic detection of an individual's contribution to an admixed DNA sample could be applied to aggregate GWAS data.
Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging.
Impact
GeneRIF
Inokuchi et al., Machida, Japan. In Science, 2009
study found in neurons, soma-derived Vesl-1S protein, prevailed in every dendrite & did not enter spines; NMDA receptor activation triggered input-specific spine entry of Vesl-1S proteins, which met many criteria for synaptic tagging
The postsynaptic density proteins Homer and Shank form a polymeric network structure.
Impact
Hayashi et al., Cambridge, United States. In Cell, 2009
Homer and Shank are among the most abundant scaffolding proteins in the PSD, working synergistically for maturation of dendritic spines.
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Impact
Worley et al., Baltimore, United States. In Science, 2008
We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation.
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain.
Impact
Kuner et al., Heidelberg, Germany. In Nat Med, 2006
Long-form Homer proteins anchor glutamatergic receptors to sources of calcium influx and release at synapses, which is antagonized by the short, activity-dependent splice variant Homer1a.
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