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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Heme oxygenase

HO-2, heme oxygenase-2
catalyzes the conversion of heme to biliverdin; involved in cellular response to oxidative stress [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, iNOS, HAD
Papers on HO-2
Uptake and release of gaseous species accompanying the reactions of isoprene photo-oxidation products with sulfate particles.
New
Martin et al., Cambridge, United States. In Phys Chem Chem Phys, Feb 2016
Gaseous species produced via the HO2 reaction pathways of isoprene photo-oxidation were reacted with liquid, partially neutralized sulfate aerosol particles at 293 ± 1 K and <5% relative humidity.
Anthropogenic sulfur perturbations on biogenic oxidation: SO2 additions impact gas-phase OH oxidation products of α-and β-pinene.
New
Farmer et al., In Environ Sci Technol, Feb 2016
These changes may be due to shifts in the OH:HO2 ratio from SO2 oxidation, and/or to SO3 reacting directly with organic molecules.
Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.
Review
New
Drummond et al., Valhalla, United States. In Trends Pharmacol Sci, Jan 2016
This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease.
A New Model of an Arteriovenous Fistula in Chronic Kidney Disease in the Mouse: Beneficial Effects of Upregulated Heme Oxygenase-1.
New
Nath et al., In Am J Physiol Renal Physiol, Jan 2016
In addition to vasculopathic genes, CKD induced potentially vasoprotective genes in the AVF such as heme oxygenase-1 (HO-1) and HO-2.
Rapid Hydrogen Shift Scrambling in Hydroperoxy Substituted Organic Peroxy Radicals.
New
Kjaergaard et al., In J Phys Chem A, Jan 2016
These very fast H-shift reactions are much faster than the reactions with NO and HO2 under most atmospheric conditions and must be included in the atmospheric modeling of volatile organic compounds where hydroperoxy peroxy radicals are formed.
CO-CBS-H2 S axis: From vascular mediator to cancer regulator.
Review
New
Kabe et al., Tokyo, Japan. In Microcirculation, Dec 2015
UNASSIGNED: Carbon monoxide (CO) is a gaseous mediator generated by heme oxygenase (HO).
Interconnection of reactive oxygen species chemistry across the interfaces of atmospheric, environmental, and biological processes.
Review
New
Impact
Ruiz-López et al., Barcelona, Spain. In Acc Chem Res, Apr 2015
Ozone (O3), hydrogen peroxide (H2O2), hydrogen polyoxides (H2Ox, x > 2), associated hydroxyl and hydroperoxyl radicals (HOx = OH and HO2), and superoxide and ozonide anions (O2(-) and O3(-), respectively) are the primary oxidants in these systems.
Chemistry in glow discharges of H2 / O2 mixtures. Diagnostics and modelling.
New
Tanarro et al., Madrid, Spain. In Plasma Sources Sci Technol, Mar 2015
The mixed ions OH(+), H2O(+) and HO2 (+) are also observed in small amounts.
Chronic Stress Decreases Cerebrovascular Responses During Rat Hindlimb Electrical Stimulation.
Suh et al., Suwŏn, South Korea. In Front Neurosci, 2014
The effect of chronic restraint stress on vasomodulator enzymes, including neuronal nitric oxide synthase (nNOS) and heme oxygenase-2 (HO-2), was assessed in the somatosensory cortex.
Genomic and pharmacogenomic biomarkers of Parkinson's disease.
Review
Agundez et al., Madrid, Spain. In Curr Drug Metab, 2014
Nor did polymorphisms in genes related to dopamine or serotonin DRD, DAT, TH, DDC, DBH, MAO, COMT, SLC6A4, MTR, MTHFR, oxidative stress NOQ1, NOQ2, mEPHX, HFE, GPX, CAT, mnSOD, HFE, HO-1, HO-2, NFE2L2, KEAP1, inflammatory processes, ILs, TNF, ACT, NOS, HNMT, ABP1, HRHs, trophic and growth factors BDNF, FGF, or mitochondrial metabolism and function.
A review on hemeoxygenase-2: focus on cellular protection and oxygen response.
Review
Chánez-Cárdenas et al., Chiconcuac, Mexico. In Oxid Med Cell Longev, 2013
Homologous HO-1 and HO-2 are microsomal proteins with more than 45% residue identity, share a similar fold and catalyze the same reaction.
Tropospheric OH and HO2 radicals: field measurements and model comparisons.
Review
Impact
Heard et al., Leeds, United Kingdom. In Chem Soc Rev, 2012
The hydroxyl radical, OH, initiates the removal of the majority of trace gases in the atmosphere, and together with the closely coupled species, the hydroperoxy radical, HO(2), is intimately involved in the oxidation chemistry of the atmosphere.
Effects of Kupffer cell blockade on the hepatic expression of metallothionein and heme oxygenase genes in endotoxemic rats with obstructive jaundice.
GeneRIF
Lázár et al., Szeged, Hungary. In Life Sci, 2012
HO mRNA levels display isoform-specific changes: those of HO-2 do not change appreciably, whereas those of HO-1 increase significantly in 2-h endotoxemia, with or without obstructive jaundice.
Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.
GeneRIF
Behrends et al., Braunschweig, Germany. In Plos One, 2011
Although the carboxy-terminal deletion mutant of HO-2 is found in the nucleus, translocation of HO-2 to the nucleus does not occur under conditions of hypoxia.
A polymorphism located at an ATG transcription start site of the heme oxygenase-2 gene is associated with classical Parkinson's disease.
GeneRIF
García-Martín et al., Badajoz, Spain. In Pharmacogenet Genomics, 2011
for the first time, copy number variations in the HMOX2 gene and an association of the SNP rs2270363 with Parkinson's disease risk.
Lack of association between the c.544G>A polymorphism of the heme oxygenase-2 gene and age-related macular degeneration.
GeneRIF
Szaflik et al., Łódź, Poland. In Med Sci Monit, 2011
Results suggest that the c.544G>A polymorphism of the heme oxygenase-2 gene is not associated with age-related macular degeneration in this population.
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells.
GeneRIF
Maya-Monteiro et al., Rio de Janeiro, Brazil. In Plos One, 2010
Erythroid precursors were characterized by lack of significant expression of HO-1 and by progressive reduction of HO-2 during differentiation.
Amplified trace gas removal in the troposphere.
Impact
Zhang et al., Jülich, Germany. In Science, 2009
In the current understanding, the recycling of OH proceeds through HO2 reacting with NO, thereby forming ozone.
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
Review
Impact
Choi et al., Pittsburgh, United States. In Physiol Rev, 2006
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2), catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (i.e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO).
Removal of Stratospheric O3 by Radicals: In Situ Measurements of OH, HO2, NO, NO2, ClO, and BrO.
Impact
Wofsy et al., In Science, 1994
Simultaneous in situ measurements of the concentrations of OH, HO(2), ClO, BrO, NO, and NO(2) demonstrate the predominance of odd-hydrogen and halogen free-radical catalysis in determining the rate of removal of ozone in the lower stratosphere during May 1993.
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