gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Heterogeneous nuclear ribonucleoprotein L-like

hnRNPLL, HNRPLL, stromal RNA regulating factor, SRRF
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: CD45, CAN, V1a, substance P, Mlp1
Papers on hnRNPLL
RNA-binding protein hnRNPLL regulates mRNA splicing and stability during B-cell to plasma-cell differentiation.
New
Rao et al., San Diego, United States. In Proc Natl Acad Sci U S A, May 2015
Heterogeneous nuclear RNA-binding protein LL (hnRNPLL) is specifically induced in terminally differentiated lymphocytes, including effector T cells and plasma cells.
The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.
Andrews et al., In Genome Biol, 2013
We show a developmentally regulated RNA-binding protein, hnRNPLL, induces retention of specific introns by sequencing RNA from T cells with an inactivating Hnrpll mutation and from B lymphocytes that physiologically downregulate Hnrpll during their differentiation.
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Rao et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Through a combination of transcriptional profiling and screening using a lentiviral short-hairpin RNA interference library, we show that both the splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secreted versus membrane-encoding Ighg2b transcripts in MPC11 plasmacytoma cell lines.
CD28 costimulation regulates genome-wide effects on alternative splicing.
Sharpe et al., Boston, United States. In Plos One, 2011
Moreover, genes dependent upon hnRNPLL, a global regulator of splicing in activated T cells, were enriched in T cells activated through TCR plus CD28 as compared to TCR alone.
Engineering [Ln(DPA)3] 3- binding sites in proteins: a widely applicable method for tagging proteins with lanthanide ions.
Otting et al., Canberra, Australia. In J Biomol Nmr, 2011
The concept is demonstrated with the hnRNPLL RRM1 domain.
Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.
GeneRIF
Hoyne et al., Canberra, Australia. In Plos One, 2010
results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT cells
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
GeneRIF
Goodnow et al., Canberra, Australia. In J Immunol, 2010
In T cells with no CD45 protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing.
Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis.
Conboy et al., Berkeley, United States. In Blood, 2009
The observation that 3 of the regulated transcripts encode RNA binding proteins (SNRP70, HNRPLL, MBNL2) may indicate significant changes in the RNA processing machinery of late erythroblasts.
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.
Impact
GeneRIF
Hoyne et al., Canberra, Australia. In Immunity, 2009
A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc exon-silencing sequence.
Alternative splicing of CD45: the tip of the iceberg.
Impact
Weiss et al., San Francisco, United States. In Immunity, 2009
In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.
A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.
GeneRIF
Lynch et al., Dallas, United States. In Rna, 2008
These data establish that hnRNP LL plays a critical and unique role in the signal-induced regulation of CD45 and demonstrate the utility of cell-based screens for the identification of novel splicing regulatory factors.
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.
Impact
GeneRIF
Rao et al., Boston, United States. In Science, 2008
identification of heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing
Alternatively spliced isoforms of a novel stromal RNA regulating factor.
GeneRIF
Benayahu et al., Tel Aviv-Yafo, Israel. In Gene, 2004
Participation of SRRF (Stromal RNA Regulating Factor) isoforms in post-transcriptional events in bone marrow stromal cells; an important role in regulation of the RNA expression that directs the bone marrow stromal cells differentiation pathway
share on facebooktweetadd +1mail to friends