Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Baltimore, United States. In Nat Genet, Aug 2015
The induction of Aire mRNA in keratinocytes depends on a functional interaction between K17 and the heterogeneous nuclear ribonucleoprotein hnRNP K. Further, K17 colocalizes with Aire protein in the nucleus of tumor-prone keratinocytes, and each factor is bound to a specific promoter region featuring an NF-κB consensus sequence in a relevant subset of K17- and Aire-dependent proinflammatory genes.
KH-RNA interactions: back in the groove.
London, United Kingdom. In Curr Opin Struct Biol, Feb 2015
The hnRNP K-homology (KH) domain is a single stranded nucleic acid binding domain that mediates RNA target recognition by a large group of gene regulators.
Role of Sam68 in post-transcriptional gene regulation.
Sevilla, Spain. In Int J Mol Sci, 2012
Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also contains some domains predicted to bind critical components in signal transduction pathways.
p53 and MDM2: antagonists or partners in crime?
Nashville, United States. In Cancer Cell, 2009
A study by Enge et al. in this issue of Cancer Cell shows that the ability of MDM2 to target hnRNP K for degradation contributes to the decision to induce apoptosis rather than cell-cycle arrest.