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RNA binding motif protein, X-linked-like 2

hnRNP G-T, Heterogeneous nuclear ribonucleoprotein G-T
This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind RNAs. This gene is intronless and is thought to be derived from a processed retroposon. However, unlike many retroposon-derived genes, this gene is not a pseudogene. The encoded protein has similarity to HNRPG and RBMY proteins and it is suggested to replace HNRPG protein function during meiotic prophase or act as a germ cell-specific splicing regulator. It primarily localizes to the nuclei of meiotic spermatocytes. This gene is a candidate for autosomal male infertility. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: RBMY, MEN, CAN, Tra2beta, IMMP2L
Papers on hnRNP G-T
Expression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biology.
Stickeler et al., Freiburg, Germany. In Int J Cancer, 2011
nuclear hnRNP G level as well as hTra2-beta1 level were independent prognostic factors for endometrial cancer progression-free survival
Novel domains in the hnRNP G/RBMX protein with distinct roles in RNA binding and targeting nascent transcripts.
Penrad-Mobayed et al., Paris, France. In Nucleus, 2010
The initial recruitment of hnRNP G to nascent pre-mRNAs is independent of its sequence-specific RNA binding properties.
The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Plos Genet, 2009
germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein.
[Knockout mice in the service of reproduction].
Escalier, Le Kremlin-BicĂȘtre, France. In Gynecol Obstet Fertil, 2008
Knockout mice can support data obtained in human, such as for HNRNPGT, whose role in the human spermatogenesis remained questionable.
Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.
Elliott et al., Newcastle upon Tyne, United Kingdom. In Hum Mol Genet, 2008
Human HNRNPGT, encoding the protein hnRNP G-T, is one of several autosomal retrogenes derived from RBMX.
The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis.
Elliott, Newcastle upon Tyne, United Kingdom. In Int J Androl, 2004
Similar pathways likely operate in germ cells and somatic cells, with RBMY, hnRNPGT and T-STAR proteins providing germ cell-specific components.
Heterogeneous nuclear ribonucleoprotein G-T (HNRNP G-T) mutations in men with impaired spermatogenesis.
Lombardi et al., Amsterdam, Netherlands. In Mol Hum Reprod, 2004
The heterogeneous nuclear ribonucleoprotein G-T (HNRNP G-T) gene is located in chromosomal region 11p15 that has been shown to be associated with impaired spermatogenesis.
HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding.
Eperon et al., Leicester, United Kingdom. In Hum Mol Genet, 2003
The hnRNP G family comprises three closely related proteins, hnRNP G, RBMY and hnRNP G-T.
Localization of the germ cell-specific protein, hnRNP G-T, in testicular biopsies of azoospermic men.
Yavetz et al., Tel Aviv-Yafo, Israel. In Acta Histochem, 2001
Heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) is a germ cell-specific protein expressed most prominently during meiosis
An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.
Cooke et al., Edinburgh, United Kingdom. In Hum Mol Genet, 2000
We have identified a new member of this gene family, HNRNP G-T, and have mapped it as a single-copy gene on chromosome 11.
RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.
Eperon et al., Leicester, United Kingdom. In Hum Mol Genet, 2000
We show here that RBM, hnRNP G and a novel testis-specific relative, termed hnRNP G-T, interact with Tra2beta, an activator of pre-mRNA splicing that is ubiquitous but highly expressed in testis.
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