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Heterogeneous nuclear ribonucleoprotein F

hnRNP F, heterogeneous nuclear ribonucleoprotein F, mcs94-1
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, POLYMERASE, Src, Insulin
Papers on hnRNP F
Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-β1-induced kidney injury in a mouse model of diabetes.
New
Chan et al., Montréal, Canada. In Diabetologia, Oct 2015
AIMS/HYPOTHESIS: We investigated whether heterogeneous nuclear ribonucleoprotein F (hnRNP F) stimulates renal ACE-2 expression and prevents TGF-β1 signalling, TGF-β1 inhibition of Ace-2 gene expression and induction of tubulo-fibrosis in an Akita mouse model of type 1 diabetes.
Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor.
New
Xie et al., Winnipeg, Canada. In Biochim Biophys Acta, Aug 2015
This TSA effect was independent of TGFβ1; however, only in the presence of TGFβ1 was TSA able to change the splicing regulators hnRNP F/H by slightly reducing their mRNA transcripts but strongly preventing protein degradation.
A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.
Eperon et al., Leicester, United Kingdom. In Cell Rep, 2014
The ESE forms at least three coexisting discrete states: a quadruplex, a complex containing only hnRNP F/H, and a complex enriched in the activator SRSF1.
A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia.
Feng et al., Atlanta, United States. In Nucleic Acids Res, 2014
Moreover, we identified a broad spectrum of in vivo functional hnRNP F/H targets in OLs that contain conserved exons flanked by G-runs, many of which are dysregulated in the qk(v) mutant.
hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Lykke-Andersen et al., San Diego, United States. In Plos One, 2013
This revealed hnRNP F as a prominent interactor of TTP and BRF1.
Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine.
Wang et al., Hangzhou, China. In Nanoscale Res Lett, 2013
The results indicated that seven protein spots, ubiquitin-conjugating enzyme E2 (E2), glutathione synthetases (GS), triosephosphate isomerase (TSP), T-complex protein 1 subunit zeta (TCPZ), lamin-B1, heterogeneous nuclear ribonucleoprotein F (hnRNP F), and superoxide dismutase [Cu-Zn] (Cu, Zn-SOD) were significantly different among all the groups.
The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stability.
Michaeli et al., Ramat Gan, Israel. In Nucleic Acids Res, 2013
The hnRNP F/H is highly expressed in the bloodstream form of the parasite, but is also functional in the procyclic form.
Heterogeneous nuclear ribonucleoproteins F and K mediate insulin inhibition of renal angiotensinogen gene expression and prevention of hypertension and kidney injury in diabetic mice.
Chan et al., Montréal, Canada. In Diabetologia, 2013
AIMS/HYPOTHESIS: We investigated whether heterogeneous nuclear ribonucleoproteins F and K (hnRNP F, hnRNP K) mediate insulin inhibition of renal Agt expression and prevention of hypertension and kidney injury in an Akita mouse model of type 1 diabetes.
The high kinetic stability of a G-quadruplex limits hnRNP F qRRM3 binding to G-tract RNA.
Allain et al., Zürich, Switzerland. In Nucleic Acids Res, 2013
We have proposed recently that hnRNP F could regulate alternative splicing by remodeling RNA structures, such as G-quadruplexes.
Dual role of G-runs and hnRNP F in the regulation of a mutation-activated pseudoexon in the fibrinogen gamma-chain transcript.
Duga et al., Milano, Italy. In Plos One, 2012
While hnRNP H did not significantly affect pseudoexon splicing, hnRNP F promoted pseudoexon inclusion, indicating that these two proteins have only partially redundant functions.
Intron retention in the alternatively spliced region of RON results from weak 3' splice site recognition.
Eperon et al., Leicester, United Kingdom. In Plos One, 2012
UV-crosslinking experiments showed binding of hnRNP F/H just 5' of these regions, but the hnRNP F/H target sequences did not mediate inhibition.
Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules.
Wang et al., Chapel Hill, United States. In Nat Struct Mol Biol, 2012
Five distinct groups were recognized by hnRNP H and hnRNP F, whose C-terminal domains were sufficient to render context-dependent activities of ISEs.
Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice.
Chan et al., Montréal, Canada. In Diabetes, 2012
We investigated the impact of heterogeneous nuclear ribonucleoprotein F (hnRNP F) overexpression on angiotensinogen (Agt) gene expression, hypertension, and renal proximal tubular cell (RPTC) injury in high-glucose milieu both in vivo and in vitro.
hnRNP F directs formation of an exon 4 minus variant of tumor-associated NADH oxidase (ENOX2).
GeneRIF
Morré et al., West Lafayette, United States. In Mol Cell Biochem, 2011
this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2.
hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.
GeneRIF
Webster et al., San Diego, United States. In Plos One, 2010
These data point to a functional interaction between hnRNP F and SRSF1 as a mutant that eliminates SRSF1 binding to exon 11, or a SRSF1 knockdown, which prevents the stimulatory effect of hnRNP F over expression.
Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
GeneRIF
Allain et al., Zürich, Switzerland. In Nat Struct Mol Biol, 2010
The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA.
Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.
GeneRIF
Gout et al., London, United Kingdom. In J Biol Chem, 2010
heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway
A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.
GeneRIF
McNally et al., Milwaukee, United States. In Mol Cell Biol, 2010
Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function.
Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
Impact
Milcarek et al., Pittsburgh, United States. In Nat Immunol, 2009
Lowering ELL2 expression by transfection of heterogenous ribonucleoprotein F (hnRNP F) or small interfering RNA resulted in lower abundance of secretory-specific forms of immunoglobulin heavy-chain mRNA.
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines.
Impact
Johnson et al., Seattle, United States. In Nat Genet, 2008
An unbiased, systematic screen of 21,760 4-mer to 7-mer words for cis-regulatory motifs identified 143 RNA 'words' enriched near regulated cassette exons, including six clusters of motifs represented by UCUCU, UGCAUG, UGCU, UGUGU, UUUU and AGGG, which map to trans-acting regulators PTB, Fox, Muscleblind, CELF/CUG-BP, TIA-1 and hnRNP F/H, respectively.
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