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HNF1 homeobox A

HNF1, MODY3, hepatocyte nuclear factor-1alpha, hepatocyte nuclear factor 1, transcription-factor, HNF1A, TCF1
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: TCF, CAN, Insulin, HAD, AGE
Papers on HNF1
Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage.
Golub et al., Chicago, United States. In Nat Immunol, Feb 2016
Using single-cell multiplex transcriptional analysis of 100 lymphoid genes and single-cell cultures of fetal liver precursor cells, we identified the common proximal precursor to these lineages and found that its bifurcation was marked by differential induction of the transcription factors PLZF and TCF1.
ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis.
Prehn et al., Dublin, Ireland. In Eur J Neurosci, Feb 2016
miR-29a did not alter the signalling branches of the ER stress response, rather its expression was controlled by the ER stress-induced transcription factor activating-transcription-factor-4 (ATF4).
A family with the Arg103Pro mutation in the NEUROD1 gene detected by Next-Generation Sequencing - clinical characteristics of mutation carriers.
Malecki et al., Kraków, Poland. In Eur J Med Genet, Feb 2016
METHODS: We included 156 diabetic probands of MODY families, among them 52 patients earlier tested for GCK-MODY and/or HNF1A-MODY by Sanger sequencing with negative results.
TCF1 links GIPR signaling to the control of beta cell function and survival.
Drucker et al., Toronto, Canada. In Nat Med, Jan 2016
Beta cells from Gipr(-/-βCell) mice display greater sensitivity to apoptosis and markedly lower islet expression of T cell-specific transcription factor-1 (TCF1, encoded by Tcf7), a protein not previously characterized in beta cells.
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-α mutated lesions.
Kluger et al., New York City, United States. In Hpb (oxford), Jan 2016
All patients' tumors with available histological subtyping (8/8) were HNF1-α mutated and had no inflammatory changes; 6 out the 9 lesions had prominent (>50%) steatotic changes.
Caveolin‑1 is essential in the differentiation of human adipose‑derived stem cells into hepatocyte‑like cells via an MAPK pathway‑dependent mechanism.
Liu et al., Dalian, China. In Mol Med Report, Jan 2016
In addition the expression levels of ALB and HNF1A significantly decreased following small interfering RNA‑mediated knockdown of Cav‑1.
Long non-coding RNA HNF1A-AS is upregulated and promotes cell proliferation and metastasis in nasopharyngeal carcinoma.
Cheng et al., Changchun, China. In Cancer Biomark, Jan 2016
OBJECTIVE: In this study, we examined the role of HNF1A-AS in NPC progression in vitro and in vivo.
The histone chaperone CAF-1 safeguards somatic cell identity.
Hochedlinger et al., Boston, United States. In Nature, Jan 2016
To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNA interference (RNAi) screens targeting chromatin factors during transcription-factor-mediated reprogramming of mouse fibroblasts to induced pluripotent stem cells (iPS cells).
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.
Craft et al., New Haven, United States. In Immunity, Nov 2015
These findings were not the result of generalized signaling attenuation in Tfh cells, because they retained the ability to flux calcium and activate NFAT-transcription-factor-dependent cytokine production.
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.
Lie et al., Erlangen, Germany. In Cold Spring Harb Perspect Biol, Oct 2015
Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli.
In vivo delivery of transcription factors with multifunctional oligonucleotides.
Murthy et al., Berkeley, United States. In Nat Mater, Jul 2015
DARTs are composed of an oligonucleotide that contains a transcription-factor-binding sequence and hydrophobic membrane-disruptive chains that are masked by acid-cleavable galactose residues.
The Diagnosis and Management of Hyperinsulinaemic Hypoglycaemia.
Hussain et al., London, United Kingdom. In J Clin Res Pediatr Endocrinol, Jun 2015
Recent advances in genetics have linked CHI to mutations in 9 genes that play a key role in regulating insulin secretion (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A and HNF1A).
Molecular mechanisms of congenital hyperinsulinism.
Hussain et al., London, United Kingdom. In J Mol Endocrinol, Apr 2015
At a molecular level, genetic abnormalities in nine different genes (ABCC8, KCNJ11, GLUD1, GCK, HNF4A, HNF1A, SLC16A1, UCP2 and HADH) have been identified which cause CHI.
Maturity-onset diabetes of the young (MODY): an update.
Böber et al., In J Pediatr Endocrinol Metab, Mar 2015
However, mutations in the HNF1A and HNF4A cause a progressive pancreatic β-cell dysfunction and hyperglycemia that can result in microvascular complications.
Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review.
de Baaij et al., In Am J Nephrol, 2014
BACKGROUND: Autosomal dominant tubulointerstitial kidney disease subtype HNF1B (ADTKD-HNF1B) is caused by a mutation in hepatocyte nuclear factor 1 homeobox beta (HNF1B).
Transcriptional networks driving enhancer function in the CFTR gene.
Harris et al., Chicago, United States. In Biochem J, 2012
Data suggest that HNF-1a has a role in regulation of gene expression of CFTR (cystic fibrosis transmembrane conductance regulator) in enterocytes; HNF1 is identified as a critical factor binding to a specific site in CFTR intron 11.
MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.
Stange et al., Stuttgart, Germany. In J Proteomics, 2012
Two novel variants in the 3'UTR of HNF1alpha were detected and four SNPs of HNF1alpha show a significant association to cholelithiasis in male gallstone patients.
Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and β-catenin interactions.
Jou et al., Taipei, Taiwan. In J Clin Invest, 2012
nuclear EBP50 facilitates colon tumorigenesis by modulating the interaction between beta-catenin and TCF-1.
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.
Huang et al., Duarte, United States. In Mol Endocrinol, 2012
Data suggest that proinflammatory cytokines (as up-regulated in microenvironment of hepatocellular carcinoma) down-regulate FXR (farnesoid X-activated receptor) by inhibiting transactivation via HNF1alpha.
Double heterozygous germline HNF1A mutations in a patient with liver adenomatosis.
Zucman-Rossi et al., In Diabetes Care, 2012
Study showed that two germline HNF1A mutations could coexist in the same patient, which could increase the risk of liver adenomatosis.
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