The histone chaperone CAF-1 safeguards somatic cell identity.
Boston, United States. In Nature, Jan 2016
To further elucidate regulatory pathways that safeguard the somatic state, we performed two comprehensive RNA interference (RNAi) screens targeting chromatin factors during transcription-factor-mediated reprogramming of mouse fibroblasts to induced pluripotent stem cells (iPS cells).
Transcription-Factor-Dependent Control of Adult Hippocampal Neurogenesis.
Erlangen, Germany. In Cold Spring Harb Perspect Biol, Oct 2015
Here, we review current knowledge in transcription factor-mediated regulation of mammalian neural stem cells and neurogenesis and will discuss potential mechanisms of how transcription factor networks, on one hand, allow for precise execution of the developmental sequence and, on the other hand, allow for adaptation of the rate and timing of adult neurogenesis in response to complex stimuli.
Molecular mechanisms of congenital hyperinsulinism.
London, United Kingdom. In J Mol Endocrinol, Apr 2015
At a molecular level, genetic abnormalities in nine different genes (ABCC8, KCNJ11, GLUD1, GCK, HNF4A, HNF1A, SLC16A1, UCP2 and HADH) have been identified which cause CHI.
Transcriptional networks driving enhancer function in the CFTR gene.
Chicago, United States. In Biochem J, 2012
Data suggest that HNF-1a has a role in regulation of gene expression of CFTR (cystic fibrosis transmembrane conductance regulator) in enterocytes; HNF1 is identified as a critical factor binding to a specific site in CFTR intron 11.