FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
Chicago, United States. In Oncogene, Feb 2016
UNASSIGNED: Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Houston, United States. In Horm Cancer, Feb 2016
In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs).
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
New Haven, United States. In Nat Genet, Jan 2016
These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer.
Seoul, South Korea. In J Breast Cancer, Dec 2015
Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome.
The Molecular Taxonomy of Primary Prostate Cancer.
In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
FOXM1 and its Oncogenic Signaling in Gastric Cancer.
Shanghai, China. In Recent Pat Anticancer Drug Discov, 2014
The transcription factor FOXM1 is overexpressed in many human cancers, including liver, stomach, prostate, brain, breast, lung, colon, pancreas, cervix, ovary and nervous system.