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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box M1

HNF-3, Hepatocyte Nuclear Factor 3-alpha, FoxM1, Foxa1
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, V1a, PCNA, CHIP, HAD
Papers using HNF-3 antibodies
Natura-alpha targets forkhead box m1 and inhibits androgen-dependent and -independent prostate cancer growth and invasion
Gartel Andrei L. et al., In Oncotarget, 2010
... Anti-FoxM1 and control siRNAs were purchased from Sigma, Fluorescent-siRNA (Allstars Negative Alexa Fluor 488) and anti-Luciferase GL3 siRNA were purchased from Qiagen.
Papers on HNF-3
Transcription Factors and Medium Suitable for Initiating the Differentiation of Human Induced Pluripotent Stem Cells to the Hepatocyte Lineage.
Ishige et al., Yotsukaidō, Japan. In J Cell Biochem, Feb 2016
CCAAT/enhancer binding protein alpha (CEBPA), CCAAT/enhancer binding protein beta (CEBPB), forkhead box A1 (FOXA1), and forkhead box A3 (FOXA3) up-regulated AFP and down-regulated Nanog.
FOXA1 acts upstream of GATA2 and AR in hormonal regulation of gene expression.
Yu et al., Chicago, United States. In Oncogene, Feb 2016
UNASSIGNED: Hormonal regulation of gene expression by androgen receptor (AR) is tightly controlled by many transcriptional cofactors, including pioneer factors FOXA1 and GATA2, which, however, exhibit distinct expression patterns and functional roles in prostate cancer.
Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.
Wang et al., Columbus, United States. In Nucleic Acids Res, Feb 2016
We employed an integrative genomics analysis of master TFs CREB1 and FoxA1 in androgen-dependent prostate cancer (ADPC) and castration-resistant prostate cancer (CRPC) cell lines, primary prostate cancer tissues and circulating tumor cells (CTCs) to investigate their role in defining prostate cancer gene expression profiles.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Mitsiades et al., Houston, United States. In Horm Cancer, Feb 2016
In this review, we discuss the preclinical research that has been done, as well as clinical trials for prostate cancer, on inhibiting several important families of AR-interacting proteins, including chaperones (such as heat shock protein 90 (HSP90) and FKBP52), pioneer factors (including forkhead box protein A1 (FOXA1) and GATA-2), and AR transcriptional coregulators such as the p160 steroid receptor coactivators (SRCs) SRC-1, SRC-2, SRC-3, as well as lysine deacetylases (KDACs) and lysine acetyltransferases (KATs).
Forkhead box transcription factors in embryonic heart development and congenital heart disease.
Zhu, Changsha, China. In Life Sci, Feb 2016
An abundance of studies in model organisms and systems has established that Foxa2, Foxc1/c2, Foxh1 and Foxm1, Foxos and Foxps are important components of the signaling pathways that instruct cardiogenesis and embryonic heart development, playing paramount roles in heart development.
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
Günel et al., New Haven, United States. In Nat Genet, Jan 2016
These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
Dissecting the role of Engrailed in adult dopaminergic neurons - Insights into Parkinson disease pathogenesis.
Joshi et al., Paris, France. In Febs Lett, Jan 2016
Foxa1/2, Lmx1a/b, Nurr1, Otx2, Pitx3) also continue to function for the survival and maintenance of mDA neurons in the adult and act through partially overlapping but also diverse mechanisms.
High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer.
Jang et al., Seoul, South Korea. In J Breast Cancer, Dec 2015
Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome.
The Molecular Taxonomy of Primary Prostate Cancer.
Cancer Genome Atlas Research Network et al., In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.
Freedman et al., Boston, United States. In Nat Genet, Nov 2015
FOXA1 and HOXB13 colocalized at the reprogrammed AR binding sites in human tumor tissue.
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.
Rich et al., Cleveland, United States. In Cancer Cell, Nov 2015
Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory axis, revealing an iron-regulated CSC pathway.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Perou et al., Lausanne, Switzerland. In Cell, Nov 2015
Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features.
miR-204 inhibits invasion and epithelial-mesenchymal transition by targeting FOXM1 in esophageal cancer.
Bai et al., Qiqihar, China. In Int J Clin Exp Pathol, 2014
Furthermore, we showed that forkhead box protein M1 (FOXM1) was a direct target gene of miR-204, and miR-204 regulated invasion and EMT in EC by acting directly on the 3'UTR of FOXM1 mRNA and suppressing its protein expression.
Prognostic Value of FOXM1 in Patients with Malignant Solid Tumor: A Meta-Analysis and System Review.
Ruan et al., Wuhan, China. In Dis Markers, 2014
Forkhead box M1 (FOXM1), a member of the Fox transcription factors family, was closely related with cell cycle.
FOXM1 and its Oncogenic Signaling in Gastric Cancer.
Huang et al., Shanghai, China. In Recent Pat Anticancer Drug Discov, 2014
The transcription factor FOXM1 is overexpressed in many human cancers, including liver, stomach, prostate, brain, breast, lung, colon, pancreas, cervix, ovary and nervous system.
Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.
Kalinichenko et al., Cincinnati, United States. In Dev Biol, 2012
Foxm1 is required for differentiation and maintenance of epithelial cells lining conducting airways.
27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells.
Sierralta et al., Santiago, Chile. In Oncol Rep, 2012
Exposure to a major circulating cholesterol metabolite initiates a phenotypic change to a mesenchymal cell type in MCF7 cells with increased expression of MnSOD, FOXM1 and estrogen receptor beta.
FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2.
Matthews et al., Toronto, Canada. In Mol Cancer Res, 2012
These findings show that FOXA1, but not ER- alpha, is essential for AHR(aryl hydrocarbon receptor) -dependent regulation of CCNG2(cyclin G2 ), assigning a role for FOXA1 in AHR action.
Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2.
Kaestner et al., Philadelphia, United States. In Plos Genet, 2011
Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution.
Stable expression of FoxA1 promotes pluripotent P19 embryonal carcinoma cells to be neural stem-like cells.
Tan et al., Changsha, China. In Gene Expr, 2011
Stable expression of FoxA1 promotes pluripotent P19 embryonal carcinoma cells to be neural stem-like cells.
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