Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.
Bethesda, United States. In Cell Metab, Jan 2016
SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.
HypoxamiRs and cancer: from biology to targeted therapy.
Sydney, Australia. In Antioxid Redox Signal, 2014
Several miR-210 target genes, including iron-sulfur (Fe-S) cluster scaffold protein (ISCU) and glycerol-3-phosphate dehydrogenase 1-like (GPD1L), have been correlated with prognosis in an inverse fashion to miR-210, suggesting that their down- regulation by miR-210 occurs in vivo and contributes to tumor growth.