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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

3-hydroxy-3-methylglutaryl-CoA synthase 1

HMGCS1, Hydroxymethylglutaryl-CoA Synthase, 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1, HMGCS
Top mentioned proteins: ACID, HMG-CoA reductase, V1a, HAD, Insulin
Papers on HMGCS1
Dietary procyanidins selectively modulate intestinal farnesoid X receptor-regulated gene expression to alter enterohepatic bile acid recirculation: elucidation of a novel mechanism to reduce triglyceridemia.
New
Ricketts et al., Reno, United States. In Mol Nutr Food Res, Jan 2016
GSPE also increased hepatic HmgCoA reductase (Hmgcr) and synthase (Hmgcs1) expression, while concomitantly decreasing sterol regulatory element-binding protein 1c (Srebp1c).
Hepatitis C virus-induced NLRP3-Inflammasome Activates the Sterol Regulatory Element Binding Protein (SREBP) and Regulates Lipid Metabolism.
New
Waris et al., Franklin, United States. In J Biol Chem, Jan 2016
Our results reveal that HCV-activated NLRP3-inflammasome is required for the upregulation of lipogenic genes such as HMGCS, FAS, and SCD.
Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane.
New
Hu et al., Beijing, China. In Acs Nano, Nov 2015
Overexpression of proteins in the lipid metabolism processes, such as E3 ubiquitin-protein ligase RNF139 (RNF139) and Hydroxymethylglutaryl-CoA synthase (HMGCS1), have not been reported previously in the study of paclitaxel resistance, suggesting possibly different mechanism between nanoparticle and single molecular drug resistance.
Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.
New
Liu et al., Hamburg, Germany. In Diabetes, Oct 2015
This network included 11 BMI-associated genes related to sterol uptake (↑LDLR, ↓MYLIP), synthesis (↑SCD, FADS1, HMGCS1, FDFT1, SQLE, CYP51A1, SC4MOL), and efflux (↓ABCA1, ABCG1), producing a molecular profile expected to increase intracellular cholesterol.
Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.
New
Penn et al., Toronto, Canada. In Oncotarget, Oct 2015
Genes of the MVA pathway were amongst the top-scoring targets, including sterol regulatory element binding transcription factor 2 (SREBP2), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1) and geranylgeranyl diphosphate synthase 1 (GGPS1).
Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation.
New
Kier et al., College Station, United States. In Am J Physiol Gastrointest Liver Physiol, Oct 2015
DKO-induced steatosis in control-fed wild-type (WT) mice was associated with 1) loss of SCP-2; 2) upregulation of liver fatty acid binding protein (L-FABP); 3) increased mRNA and/or protein levels of sterol regulatory element binding proteins (SREBP1 and SREBP2) as well as increased expression of target genes of cholesterol synthesis (Hmgcs1 and Hmgcr) and fatty acid synthesis (Acc1 and Fas); and 4) cholesteryl ester accumulation was also associated with increased acyl-CoA cholesterol acyltransferase-2 (ACAT2) in males.
Proteomic analysis of conidia germination in Fusarium oxysporum f. sp. cubense tropical race 4 reveals new targets in ergosterol biosynthesis pathway for controlling Fusarium wilt of banana.
New
Yi et al., Guangzhou, China. In Appl Microbiol Biotechnol, Sep 2015
Four enzymes, C-24 sterol methyltransferase (ERG6), cytochrome P450 lanosterol C-14α-demethylase (EGR11), hydroxymethylglutaryl-CoA synthase (ERG13), and C-4 sterol methyl oxidase (ERG25), in the ergosterol biosynthesis pathway were identified and verified, and they hold great promise as new targets for effective inhibition of Foc TR4 early growth in controlling Fusarium wilt of banana.
Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S.
New
Mašič et al., Ljubljana, Slovenia. In Toxicol In Vitro, Aug 2015
For BPAF and BPS, the 'isoprenoid biosynthetic process' was enriched (up-regulated genes: HMGCS1, PDSS1, ACAT2, RCE1, DHDDS).
Regulation of gene expression in rats with spinal cord injury based on microarray data.
New
Yu et al., Beijing, China. In Mol Med Report, Aug 2015
HMGCS1, FDFT1 and IDI1) were negatively correlated with time, while injury genes (e.g.
17β-Trenbolone exposure programs metabolic dysfunction in larval medaka.
New
Nishida et al., Tsukuba, Japan. In Environ Toxicol, Jul 2015
Thirteen genes (including those for hydroxymethylglutaryl-CoA synthase, cytoplasmic synthase, and lanosterol synthase) related to cholesterol biosynthesis via the mevalonate pathway were highlighted in these categories.
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids.
Tsang et al., Bonn, Germany. In J Ovarian Res, 2014
RESULTS: A total of 573 gene transcripts, including CPA1, CDH1, INSL3, AMH, ALDH1B1, INHBA, CYP17A1, RBP4, GAS6, GAS7 and GATA4, were activated while 430 others including HSD17B7, HSD3B6, STAR, HMGCS1, HMGCR, CYP51, CYP11A1 and CYP19A1 were repressed in DHT-treated ovaries.
Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.
Stern et al., New Haven, United States. In Sci Signal, 2014
Expression of the ERBB4 ICD in mammary epithelial cells or activation of ERBB4 with the ligand neuregulin 1 (NRG1) induced the expression of SREBP target genes involved in cholesterol biosynthesis, including HMGCR and HMGCS1, and lipid uptake, LDLR, which encodes the LDL receptor.
Response of the cholesterol metabolism to a negative energy balance in dairy cows depends on the lactational stage.
Bruckmaier et al., Bern, Switzerland. In Plos One, 2014
In comparison, C concentration and mass in milk were elevated in week 1 p.p. Hepatic mRNA abundance of sterol regulatory element-binding factor-2 (SREBF-2), 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1 (HMGCS1), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), and ATP-binding cassette transporter (ABCA1) were similar in CON and RES cows during feed restriction, but were upregulated during NEB in week 1 p.p. compared to the non-lactating stage without a NEB.
AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
Zhao et al., Jinan, China. In Plos One, 2014
Here, we demonstrate that the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and its target genes HMGCR and HMGCS, which are key enzymes in cholesterol biosynthesis, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells; similar results were obtained in TSH receptor knockout mice.
Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
GeneRIF
Yue et al., Oxford, United Kingdom. In J Mol Biol, 2010
The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.
GeneRIF
Nitz et al., Kiel, Germany. In Cell Physiol Biochem, 2007
ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway.
Metabolic adaptations to change of nutrition at birth.
Review
Girard, Meudon, France. In Biol Neonate, 1989
The appearance of ketogenesis is also controlled by the changes of plasma insulin and glucagon that increase the capacity for liver fatty acid oxidation by decreasing lipogenesis and malonyl-CoA concentration, by reducing the sensitivity of carnitine palmitoyl-CoA I to the inhibitory influence of malonyl-CoA, and by activating hydroxymethylglutaryl-CoA synthase by desuccinylation.
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