RNA-Mediated Regulation of HMGA1 Function.
In Biomolecules, 2014
The high mobility group protein A1 (HMGA1) is a master regulator of chromatin structure mediating its major gene regulatory activity by direct interactions with A/T-rich DNA sequences located in the promoter and enhancer regions of a large variety of genes.
Recent advances in molecular and cell biology of testicular germ-cell tumors.
Caserta, Italy. In Int Rev Cell Mol Biol, 2013
Many discovered biomarkers including OCT3/4, SOX2, SOX17, HMGA1, Nek2, GPR30, Aurora-B, estrogen receptor β, and others have given further advantages to discriminate between histological subgroups and could represent useful novel molecular targets for antineoplastic strategies.
Coordination of a transcriptional switch by HMGI(Y) acetylation.
New York City, United States. In Science, 2001
The enhanceosome activates transcription by recruiting the histone acetyltransferase proteins CREB binding protein (CBP) and p300/CBP-associated factors (PCAF)/GCN5, which, in addition to modifying histones, acetylate HMGI(Y), the architectural component required for enhanceosome assembly.
In vivo modulation of Hmgic reduces obesity.
United States. In Nat Genet, 2000
The HMGI family of proteins consists of three members, HMGIC, HMGI and HMGI(Y), that function as architectural factors and are essential components of the enhancesome.