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High mobility group AT-hook 1

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using HMGA1a antibodies
Antagonism of Myc functions by Arf
Resar Linda MS et al., In BMC Genomics, 2003
... HMGA1 transgenic mice at 2 months with ...
Papers on HMGA1a
The high-mobility group A1-estrogen receptor β nuclear interaction is impaired in human testicular seminomas.
Chieffi et al., Napoli, Italy. In J Cell Physiol, 2012
These results suggest that exposure to estrogens or estrogen-mimics, in some as of yet undefined manner, diminishes the ERbeta-mediated growth restraint in human testicular seminoma.
HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells.
Gotoh et al., Tokyo, Japan. In Nat Neurosci, 2012
HMGA1 contributes to the neurogenic potential of neural precursor cells in the early stages of neocortical development.
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
Fusco et al., Napoli, Italy. In J Clin Endocrinol Metab, 2012
Down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1 in human pituitary GH adenomas.
Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals.
Wang et al., Wuhan, China. In Diabetologia, 2012
HMGA1 is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.
Knockdown of HMGA1 expression by short/small hairpin RNA inhibits growth of ovarian carcinoma cells.
Zhang et al., Harbin, China. In Biotechnol Appl Biochem, 2012
knockdown of HMGA1 expression in OVCAR cells could change cell morphology, decrease cell proliferation, and reduce invasion in vitro
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