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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

High mobility group 20A

HMG20A
Top mentioned proteins: Vps26, HAD, CAN, SET, WFS1
Papers on HMG20A
HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition.
New
Reyes et al., Sevilla, Spain. In Oncogene, Nov 2015
HMG20A is a high mobility group (HMG) domain containing protein homologous to HMG20B, a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex.
Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects.
New
Humphries et al., Lahore, Pakistan. In Eur J Hum Genet, Oct 2015
UNASSIGNED: The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity.
Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies.
New
Harries et al., Exeter, United Kingdom. In Diabetes, Apr 2015
A significant allelic expression imbalance (AEI) was identified for 7/14 (50%) genes tested (ANPEP, CAMK2B, HMG20A, KCNJ11, NOTCH2, SLC30A8, and WFS1), with significant AEI confirmed for five of these genes using other linked exonic SNPs.
Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian Population.
Albagha et al., Riyadh, Saudi Arabia. In Clin Endocrinol (oxf), 2014
Analysis of a subgroup of subjects with BMI≤30 resulted in two additional loci (SLC30A8; P = 0·03, HMG20A; P = 0·02) showing significant association with T2D.
Genetic association study between the detected risk variants based upon type II diabetes GWAS and psychotic disorders in the Japanese population.
Iwata et al., Japan. In J Hum Genet, 2014
To avoid type II error, we genotyped the top three SNPs in BCL11A, HMG20A and HNF4A showing associations with any of the phenotypes (Puncorrected <0.01) using independent samples to replicate the nominal associations.
The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.
Jans et al., Australia. In Biochim Biophys Acta, 2013
Here we report characterization for the first time of three of these: the high mobility group (HMG)-box-domain-containing chromatin component HMG20A, nuclear mitotic apparatus protein NuMA1 and synaptic nuclear envelope protein SYNE2.
Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort.
Pedersen et al., Copenhagen, Denmark. In J Clin Endocrinol Metab, 2013
CONTEXT: Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry.
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
GeneRIF
Cauchi et al., Exeter, United Kingdom. In Plos Genet, 2012
we report associations with the LAMA1 and HMG20A (not previously associated at genome-wide significance in Europeans) gene regions with type 2 diabetes risk
A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population.
Maeda et al., Yokohama, Japan. In Plos One, 2011
METHODS: We genotyped 11,319 Japanese participants (8,318 with type 2 diabetes and 3,001 controls) for each of the 7 SNPs-rs5945326 near DUSP9, rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, rs2028299 near AP3S2, and rs4812829 in HNF4A-and examined the association of each of these 7 SNPs with type 2 diabetes by using logistic regression analysis.
Genome-wide association studies-derived susceptibility loci in type 2 diabetes: confirmation in a Chinese population.
Zhou et al., Wuhan, China. In Clin Invest Med, 2011
METHODS: Five single nucleotide polymorphisms (SNPs) were genotyped: rs3923113 near GRB14, rs16861329 in ST6GAL1, rs1802295 in VPS26A, rs7178572 in HMG20A, and rs231362 near KCNQ1, by high-resolution melting (HRM) of small amplicons.
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
Impact
Chambers et al., London, United Kingdom. In Nat Genet, 2011
In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)).
The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
GeneRIF
Macioce et al., Roma, Italy. In J Biol Chem, 2010
beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
A poxvirus host range protein, CP77, binds to a cellular protein, HMG20A, and regulates its dissociation from the vaccinia virus genome in CHO-K1 cells.
Chang et al., Taipei, Taiwan. In J Virol, 2006
In yeast two-hybrid analyses, CP77 bound to a cellular protein, HMG20A, and GST pulldown analyses showed that residues 1 to 234 of CP77 were sufficient for this interaction.
HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression.
Peral et al., Barcelona, Spain. In Cytogenet Cell Genet, 1999
We describe HMG20A and HMG20B, two novel human HMG box-containing genes, discovered within the EURO-IMAGE Consortium full-length cDNA sequencing initiative.
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