Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.
Singapore, Singapore. In Stem Cells, Oct 2015
Loss of epigenetic stemness features also correlated with intragenic CpG hypomethylation and reduced expression of HMGB2, coding high mobility group protein 2. We show that knockdown of this sequence-independent chromatin protein in HESCs promotes senescence and impairs decidualization, exemplified by blunted time-dependent secretome changes.
Nuclear war: the granzyme A-bomb.
Boston, United States. In Curr Opin Immunol, 2003
A special target of the granzyme A cell death pathway is an endoplasmic reticulum-associated complex, called the SET complex, which contains three granzyme A substrates, the nucleosome assembly protein SET, the DNA bending protein HMG-2, and the base excision repair endonuclease Ape1.
RAGged repair: what's new in V(D)J recombination.
Zürich, Switzerland. In Biol Chem, 1997
Hence, it became obvious that the initial steps of the reaction are carried out by the lymphocyte-specific proteins RAG1 and RAG2 (recombination-activating genes), with the help of members of the high mobility group protein family of DNA-binding proteins, HMG1 or HMG2.