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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

HMG-CoA reductase, HMGCR
Top mentioned proteins: CAN, ACID, HAD, V1a, HDL
Papers using HMG-CoA reductase antibodies
Statin use is associated with improved prostate cancer survival: is it time for a clinical trial?
Supplier
Agoulnik Irina, In PLoS ONE, 2009
... Antibody for 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR (C-1)) was from Santa Cruz Biotechnology, Inc ...
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Supplier
Blagosklonny Mikhail V., In PLoS ONE, 2005
... PPARα, PPARγ, pAMPK, pAkt, pJNK, and hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies were purchased from Santa Cruz Biotechnology and Upstate Cell Signaling ...
Regulation of cholesterol biosynthesis
Supplier
Wu Chieh-Hsi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1985
... -actin (#ab6276) and HMGCR (#07-457) were purchased from Abcam (Cambridge, MA, USA) and ...
Papers on HMG-CoA reductase
The diabetogenic action of statins - mechanisms and clinical implications.
Review
New
Carmena et al., Valencia, Spain. In Nat Rev Endocrinol, Feb 2016
Mechanisms underpinning this effect are not yet fully understood; however, Mendelian randomization studies suggest that they are related to lowered activity of HMG-CoA reductase, the target of statin therapy.
Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.
New
Jirousek et al., In J Med Chem, Feb 2016
The fatty acid niacin conjugate 5 has been shown to be an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase and NPC1L1.
Immune-mediated necrotizing myopathy.
New
Martinet et al., Rouen, France. In Z Rheumatol, Feb 2016
An autoimmune aspect of IMNM is suggested by its association with autoantibodies directed against signal recognition particle (SRP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the majority of patients.
Review article: inhibition of methanogenic archaea by statins as a targeted management strategy for constipation and related disorders.
Review
New
Pimentel et al., Rockville, United States. In Aliment Pharmacol Ther, Jan 2016
While it is generally believed that statins inhibit methane production via their effect on cell membrane biosynthesis, mediated by inhibition of the HMG-CoA reductase, there is accumulating evidence for an alternative or additional mechanism of action where statins inhibit methanogenesis directly.
A novel MVA-mediated pathway for isoprene production in engineered E. coli.
New
Liu et al., Qingdao, China. In Bmc Biotechnol, Dec 2015
A novel biosynthetic pathway of isoprene in E. coli was established by co-expressing the heterologous mvaE gene encoding acetyl-CoA acetyltransferase/HMG-CoA reductase and mvaS gene encoding HMG-CoA synthase from Enterococcus faecalis, fatty acid decarboxylase (OleTJE) and oleate hydratase (OhyAEM).
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.
New
Hadzopoulou-Cladaras et al., Thessaloníki, Greece. In Plos One, Dec 2015
Previously, we have shown that camphene, a constituent of mastic gum oil, lowers cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity, suggesting that its hypocholesterolemic and hypotriglyceridemic effects are associated with a mechanism of action different than that of statins.
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
New
Impact
Pahan et al., Chicago, United States. In Cell Metab, Sep 2015
Here, statins, inhibitors of HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of neurotrophins in brain cells independent of the mevalonate pathway.
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
New
Impact
Sattar et al., Cambridge, United Kingdom. In Lancet, Feb 2015
We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.
Molecular and Biochemical Analysis of the Estrogenic and Proliferative Properties of Vitamin E Compounds.
Silvente-Poirot et al., Toulouse, France. In Front Oncol, 2014
These effects of δ-TT were found to act through the down regulation of HMG-CoA reductase (HMGR) activity, establishing that ERs are not involved in this effect.
Role of Nutraceuticals in Hypolipidemic Therapy.
Review
Averna et al., Palermo, Italy. In Front Cardiovasc Med, 2014
The different nutraceuticals may have different mechanisms of action: inhibition of cholesterol synthesis primarily through action on the enzyme HMG-CoA reductase (policosanol, polyphenols, garlic and, above all, red yeast rice), increase in LDL receptor activity (berberine), reduction of intestinal cholesterol absorption (garlic, plant sterols, probiotics), and also the ability to interfere with bile metabolism (probiotics, guggul).
The stats are in: an update on statin use in COPD.
Review
Reid et al., Boston, United States. In Int J Chron Obstruct Pulmon Dis, 2014
One such class of medications, HMG-CoA reductase inhibitors, have been evaluated in the COPD population.
Role of Monocarboxylate Transporter in Statin-induced Cytotoxicity.
Review
Kobayashi, Japan. In Yakugaku Zasshi, 2014
Although exercise and drug therapy are important to prevent progression of arteriosclerotic disease, exercise leads to an increase in muscular disorder induced by HMG-CoA reductase inhibitors (statins).
Metabolic control of YAP and TAZ by the mevalonate pathway.
Impact
Del Sal et al., Trieste, Italy. In Nat Cell Biol, 2014
Inhibition of the rate-limiting enzyme of this pathway (HMG-CoA reductase) by statins opposes YAP/TAZ nuclear localization and transcriptional responses.
Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.
Impact
Jarosch et al., Berlin, Germany. In Nat Cell Biol, 2014
Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA reductase degradation ligase (HRD ligase) and degraded by cytosolic 26S proteasomes.
The increasingly complex mechanism of HMG-CoA reductase.
Review
Impact
Stauffacher et al., United States. In Acc Chem Res, 2013
HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide.
Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
GeneRIF
Ishibashi et al., Tochigi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Hepatocyte HMGCR is essential for the survival of mice, and its abrogation elicits hepatic steatosis with jaundice and hypoglycemia.
Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.
GeneRIF
Lee et al., Seoul, South Korea. In Febs Lett, 2011
Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms.
Functional promoter polymorphisms govern differential expression of HMG-CoA reductase gene in mouse models of essential hypertension.
GeneRIF
Mahapatra et al., Chennai, India. In Plos One, 2010
mechanistic basis for the differential Hmgcr expression in these mouse models of human essential hypertension and implications for better understanding the role of this gene in regulation of blood pressure
Effects of buckwheat sprouts on plasma and hepatic parameters in type 2 diabetic db/db mice.
GeneRIF
Ayugase et al., Morioka, Japan. In J Food Sci, 2010
Although gene expressions of HMG-CoAR and CYP7A1 in diabetic buckwheat sprout-fed groups were higher than in the diabetic control group, the elevation of mRNA level of CYP7A1 was greater than that of HMG-CoAR.
Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.
GeneRIF
Molyneaux et al., Cleveland, United States. In Bmc Dev Biol, 2007
Cholesterol synthesis was blocked in culture by inhibiting the activity of HMG CoA reductase (HMGCR) resulting in germ cell survival and migration defects
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