HMGNs: The enhancer charmers.
Victoria, Canada. In Bioessays, Jan 2016
For over 35 years, the high-mobility group nucleosome-binding chromosomal proteins HMGN1 and HMGN2 have been shown to play a role in the establishment of these chromatin-accessible domains at transcriptional regulatory elements, namely promoters and enhancers.
DNA damage response and transcription.
Leiden, Netherlands. In Dna Repair (amst), 2011
CSB functions as a repair coupling factor to attract NER proteins, chromatin remodelers and the CSA-E3-ubiquitin ligase complex to the stalled RNAPIIo; CSA is dispensable for attraction of NER proteins, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1 and TFIIS.
HMGNs, DNA repair and cancer.
Bethesda, United States. In Biochim Biophys Acta, 2010
High Mobility Group N1 (HMGN1) protein is an emerging factor that is important for chromatin alterations in response to DNA damage originated from both ultra violet light (UV) and ionizing irradiation (IR).