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High mobility group nucleosome binding domain 1

HMG-14, HMGN1
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HMG-17, Histone, CAN, ACID, H1
Papers on HMG-14
HMGNs: The enhancer charmers.
New
Ausió et al., Victoria, Canada. In Bioessays, Jan 2016
For over 35 years, the high-mobility group nucleosome-binding chromosomal proteins HMGN1 and HMGN2 have been shown to play a role in the establishment of these chromatin-accessible domains at transcriptional regulatory elements, namely promoters and enhancers.
High mobility group B1 and N1 (HMGB1 and HMGN1) are associated with tumor-infiltrating lymphocytes in HER2-positive breast cancers.
New
Gong et al., Seoul, South Korea. In Virchows Arch, Dec 2015
We tested whether potential triggers for this response could include high mobility group B1 and N1 (HMGB1 and HMGN1) proteins, which are immunogenic damage-associated molecular pattern molecules.
High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer.
New
Ren et al., Tianjin, China. In Tumour Biol, Dec 2015
The involvement of alarmin high-mobility group nucleosome-binding protein 1 (HMGN1) in non-small cell lung cancer (NSCLC) is unknown.
Hmgn1 acts downstream of C/EBPβ to regulate the decidualization of uterine stromal cells in mice.
New
Yue et al., Changchun, China. In Cell Cycle, Dec 2015
Although Hmgn1 is involved in the regulation of gene expression and cellular differentiation, its physiological roles on the differentiation of uterine stromal cells during decidualization still remain unknown.
Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.
New
Bustin et al., Bethesda, United States. In Genome Res, Sep 2015
We now show that HMGN1 and HMGN2, nucleosome-binding proteins that are ubiquitously expressed in vertebrate cells, maintain the DHS landscape of mouse embryonic fibroblasts (MEFs) synergistically.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
New
Deary et al., Edinburgh, United Kingdom. In Mol Psychiatry, Feb 2015
We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10(-6)).
Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels.
Oppenheim et al., Frederick, United States. In Biomaterials, 2014
The plasmid, DNA(TA), encapsulated within these gels encodes for a melanoma-specific gp100 antigen fused to the alarmin protein adjuvant HMGN1.
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Impact
Weinstock et al., Boston, United States. In Nat Genet, 2014
Overexpression of HMGN1, a nucleosome remodeling protein encoded on chromosome 21q22 (refs.
HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.
GeneRIF
Wilson et al., United States. In J Biol Chem, 2012
a regulatory role for HMGN1 in PARP-1 activation.
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
GeneRIF
Oppenheim et al., Frederick, United States. In J Exp Med, 2012
extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses.
The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.
GeneRIF
Bustin et al., Bethesda, United States. In J Biol Chem, 2012
HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice
DNA damage response and transcription.
Review
Mullenders et al., Leiden, Netherlands. In Dna Repair (amst), 2011
CSB functions as a repair coupling factor to attract NER proteins, chromatin remodelers and the CSA-E3-ubiquitin ligase complex to the stalled RNAPIIo; CSA is dispensable for attraction of NER proteins, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1 and TFIIS.
Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.
GeneRIF
Zhao et al., Bethesda, United States. In Mol Cell Biol, 2011
HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites.
Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.
GeneRIF
Duester et al., Los Angeles, United States. In Dev Dyn, 2010
Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis.
HMGNs, DNA repair and cancer.
Review
Gerlitz, Bethesda, United States. In Biochim Biophys Acta, 2010
High Mobility Group N1 (HMGN1) protein is an emerging factor that is important for chromatin alterations in response to DNA damage originated from both ultra violet light (UV) and ionizing irradiation (IR).
Signalling to chromatin through post-translational modifications of HMGN.
Review
Mahadevan et al., Oxford, United Kingdom. In Biochim Biophys Acta, 2010
One class of such are the High-Mobility Group (HMG) proteins which are architectural DNA and nucleosome-binding proteins that may be subdivided into three families; HMGA (HMGI/Y/C), HMGB (HMG1/2) and HMGN (HMG14/17).
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
Impact
GeneRIF
Bustin et al., Bethesda, United States. In Nat Cell Biol, 2009
Thus, by regulating the levels of histone modifications, HMGN1 affects ATM activation.
Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects.
Review
Mullenders et al., Leiden, Netherlands. In Cell Res, 2008
CSA is dispensable for attraction of NER proteins, yet in cooperation with CSB is required to recruit XAB2, the nucleosomal binding protein HMGN1 and TFIIS.
MSK activation and physiological roles.
Review
Arthur, Dundee, United Kingdom. In Front Biosci, 2007
In cells MSKs phosphorylate several substrates including CREB, NFkB, HMGN1 and histone H3.
Stimulation of RNA polymerase II elongation by chromosomal protein HMG-14.
Impact
Hansen et al., Boston, United States. In Science, 1994
The high-mobility group protein 14 (HMG-14) is a non-histone chromosomal protein that is preferentially associated with transcriptionally active chromatin.
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