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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cholinergic receptor, muscarinic 2

hm2, CHRM2, muscarinic acetylcholine receptor M2, 7TM receptor
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on hm2
[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].
GeneRIF
Sigala et al., Brescia, Italy. In Urologia, 2012
Exposure to the cholinergic agonist carbachol induced a concentration-dependent increase in cell proliferation rate. This effect was mainly mediated by the receptor subtypes M3 and M2.
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Impact
GeneRIF
Kobayashi et al., Tokyo, Japan. In Nature, 2012
Xray structure of the antagonist-bound human M2 receptor, the first human acetylcholine receptor to be characterized structurally
Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome.
GeneRIF
Blaes et al., Gießen, Germany. In Pain, 2011
Identification of functionally active autoantibodies to CHRM2 in serum samples from complex regional pain syndrome (CRPS) patients supports an autoimmune pathogenesis of CRPS.
Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
GeneRIF
Dick et al., Richmond, United States. In Child Dev, 2011
Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2.
Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence.
GeneRIF
Hutchison et al., Albuquerque, United States. In J Abnorm Child Psychol, 2011
SNP rs1455858 associated with adolescent substance abuse and temperamental risk factors
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