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Helicase-like transcription factor

HLTF, helicase-like transcription factor, HIP116
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, CAN, Ubiquitin, BRG1, MLH1
Papers on HLTF
Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes.
Tiwari et al., Gwalior, India. In Gene, Mar 2016
MATERIALS AND METHODS: Methylation specific PCR for seven tumour associated genes, viz., MASPIN, 14-3-3 sigma gene, THBS1, FLNC, HLTF, COX-2 and SOCS1, was performed in 50 gallbladder cancer (GBC), 30 gall stone diseases (GSD) and their respective adjacent control tissues.
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo.
Ahnfelt-Rønne et al., Denmark. In Mol Endocrinol, Jan 2016
These included several proteins, not previously associated with pregnancy-induced islet expansion, such as CLIC1, STMN1, MCM6, PPIB, NEDD4, and HLTF.
Human HLTF mediates postreplication repair by its HIRAN domain-dependent replication fork remodelling.
Haracska et al., Szeged, Hungary. In Nucleic Acids Res, Jan 2016
Human HLTF, implicated in error-free replication of damaged DNA and tumour suppression, exhibits a HIRAN domain, a RING domain, and a SWI/SNF domain facilitating DNA-binding, PCNA-polyubiquitin-ligase, and dsDNA-translocase activities, respectively.
SMARCAL1 maintains telomere integrity during DNA replication.
Cortez et al., Nashville, United States. In Proc Natl Acad Sci U S A, Jan 2016
The SMARCAL1 (SWI/SNF related, matrix-associated, actin-dependent, regulator of chromatin, subfamily A-like 1) DNA translocase is one of several related enzymes, including ZRANB3 (zinc finger, RAN-binding domain containing 3) and HLTF (helicase-like transcription factor), that are recruited to stalled replication forks to promote repair and restart replication.
The helicase-like transcription factor (HLTF) in cancer: loss of function or oncomorphic conversion of a tumor suppressor?
Belayew et al., Mons, Belgium. In Cell Mol Life Sci, Nov 2015
UNASSIGNED: The Helicase-like Transcription Factor (HLTF) belongs to the SWI/SNF family of proteins involved in chromatin remodeling.
Crystallographic study of a novel DNA-binding domain of human HLTF involved in the template-switching pathway to avoid the replication arrest caused by DNA damage.
Hashimoto et al., Shizuoka, Japan. In Acta Crystallogr Sect F Struct Biol Commun, Jun 2015
HLTF is a pivotal protein in the template-switching pathway that allows DNA synthesis to continue even in the presence of DNA damage by utilizing a newly synthesized undamaged strand as a template.
Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance.
Hashimoto et al., Shizuoka, Japan. In J Biol Chem, Jun 2015
HLTF (helicase-like transcription factor) is a yeast RAD5 homolog found in mammals.
MicroRNA-145 contributes to enhancing radiosensitivity of cervical cancer cells.
Li et al., Shanghai, China. In Febs Lett, Apr 2015
We show that miR-145 targets the DNA damage repair-associated gene Helicase-like transcription factor (HLTF), which is involved in radio-resistance.
Analysis of SHPRH functions in DNA repair and immunoglobulin diversification.
Jungnickel et al., Jena, Germany. In Dna Repair (amst), 2014
An error-free bypass pathway may be initiated via K63-linked PCNA polyubiquitination by Ubc13/Mms2 and the E3 ligase Rad5 in yeast, or HLTF/SHPRH in vertebrates.
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Brosh et al., Baltimore, United States. In Biomolecules, 2014
Degradation of the helicase-like transcription factor (HLTF), a DNA translocase and ubiquitylating enzyme, influences the choice of post replication repair (PRR) pathway.
Identification of distal enhancers for Six2 expression in pronephros.
Ochi et al., Yamagata, Japan. In Int J Dev Biol, 2014
Motif analysis of transcription factors combined with phylogenetic footprinting revealed the enrichment of putative T-cell factor (Tcf)-, Hox-, and SWI/SNF complex helicase-like transcription factor (Hltf)- and AT-rich interactive domain 3A (Arid3a)-binding motif sequences in these enhancers.
Rad5 plays a major role in the cellular response to DNA damage during chromosome replication.
Tercero et al., Madrid, Spain. In Cell Rep, 2014
Here, we show that Rad5(HLTF/SHPRH), which mediates the error-free branch, has a major role in the response to DNA damage caused by methyl methanesulfonate (MMS) during chromosome replication, whereas translesion synthesis polymerases make only a minor contribution.
USP7 regulates the stability and function of HLTF through deubiquitination.
Ping et al., Shanghai, China. In J Cell Biochem, 2011
results delineate a previously unknown USP7-HLTF-PCNA molecular network controlling DNA damage response
Loss of HLTF function promotes intestinal carcinogenesis.
Ding et al., Winnipeg, Canada. In Mol Cancer, 2011
Results demonstrate that loss of HLTF function promotes the malignant transformation of intestinal or colonic adenomas to carcinomas by inducing genomic instability.
Coordinated protein and DNA remodeling by human HLTF on stalled replication fork.
Haracska et al., Szeged, Hungary. In Proc Natl Acad Sci U S A, 2011
HLTF can displace a broad spectrum of proteins such as replication protein A (RPA), PCNA, and replication factor C (RFC), thereby providing the first example for a protein clearing activity at the stalled replication fork.
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Cimprich et al., Stanford, United States. In Mol Cell, 2011
HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.
Helicase-like transcription factor confers radiation resistance in cervical cancer through enhancing the DNA damage repair capacity.
Park et al., Ch'ŏngju, South Korea. In J Cancer Res Clin Oncol, 2011
results suggest that HLTF is involved in DNA repair and apoptosis in cancer cells, which might represent a target for gene therapies of human cancer
Genetics of human iris colour and patterns.
Larsson et al., Brisbane, Australia. In Pigment Cell Melanoma Res, 2009
A model is presented whereby this SNP, serving as a target site for the SWI/SNF family member HLTF, acts as part of a highly evolutionary conserved regulatory element required for OCA2 gene activation through chromatin remodelling.
The helicase-like transcription factor and its implication in cancer progression.
Saussez et al., Mons, Belgium. In Cell Mol Life Sci, 2008
HLTF activation was recently linked to the initial steps of carcinogenesis in an experimental model of estrogen-induced kidney tumor. [REVIEW]
After chromatin is SWItched-on can it be RUSHed?
Chilton et al., Lubbock, United States. In Mol Cell Endocrinol, 1999
The SWI/SNF-related family of RUSH proteins which includes RUSH-1alpha and beta, hHLTF, HIP116, Zbu1, P113, and the transcription factor RUSH-1alpha isolog has been implicated as a highly conserved DNA binding site-specific ATPase.
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