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Major histocompatibility complex, class II, DM alpha

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DMB, MHC, DRB1, POLYMERASE, DRA
Papers on HLA-DMA
Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study.
Lei et al., Suzhou, China. In J Clin Neurol, Oct 2015
In particular, four of the novel genes, those encoding myelin oligodendrocyte glycoprotein (MOG), coiled-coil alpha-helical rod protein 1 (CCHCR1), human leukocyte antigen complex group 22 (HCG22), and major histocompatibility complex, class II, DM alpha (HLA-DMA), were supported by the evidence of both.
Screening of differentially expressed genes associated with human glioblastoma and functional analysis using a DNA microarray.
Jin et al., Changchun, China. In Mol Med Report, Aug 2015
A close correlation was demonstrated between six important genes, associated with immune response, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-B, HLA-DMA and HLA-DRA, and the immune response.
Expression patterns of immune-associated genes in external genital and perianal warts treated with sinecatechins.
Tyring et al., Houston, United States. In Viral Immunol, May 2015
In the antigen processing array, HLA-A, HLA-C, HLA-DMA, HLA-DMB, HLA-F, PSMA5, PSMB8, and PSMB9 were differentially downregulated.
HLA-DMA polymorphisms differentially affect MHC class II peptide loading.
Freund et al., Berlin, Germany. In J Immunol, Feb 2015
As HLA-DM activity directly favors immunodominant peptide presentation, polymorphisms in HLA-DM (DMA or DMB chain) might well be a contributing risk factor for autoimmunity and immune disorders.
Tumor hypomethylation at 6p21.3 associates with longer time to recurrence of high-grade serous epithelial ovarian cancer.
Goode et al., Port Saint Lucie, United States. In Cancer Res, 2014
Hypomethylation of CpGs located in 6p21.3 in the R class associated with cis upregulation of genes enriched in immune response processes (TAP1, PSMB8, PSMB9, HLA-DQB1, HLA-DQB2, HLA-DMA, and HLA-DOA), increased CD8 T-cell tumor infiltration (P=7.6×10(-5)), and trans-regulation of genes in immune-related pathways (P=1.6×10(-32)).
Transcriptional profiling and co-expression network analysis identifies potential biomarkers to differentiate chronic hepatitis B and the caused cirrhosis.
Su et al., Shanghai, China. In Mol Biosyst, 2014
We validated the five core genes, CASP1, TGFBI, IFI30, HLA-DMA and PAG1 in CHB (n = 60) and HBC (n = 60) by quantitative RT-PCR.
Differential gene expression profiling analysis in workers occupationally exposed to benzene.
Tian et al., Beijing, China. In Sci Total Environ, 2014
4) Signet analysis showed that PIK3R1, PIK3CG, PIK3R2, GNAI3, KRAS, NRAS, NFKB1, HLA-DMA, and HLA-DMB were key genes involved in benzene hematotoxicity.
Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study.
Yu et al., Nanjing, China. In Bmc Infect Dis, 2013
METHODS: The current study determined the genotypes of 34 tagging-SNPs (single nucleotide polymorphisms) from 9 candidate genes (HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, TAP1, TAP2, LMP2, LMP7, and tapasin) in a Chinese population of paid blood donors with high risk of HCV infection.
Pathway analysis of genome-wide association studies on rheumatoid arthritis.
Lee et al., Seoul, South Korea. In Clin Exp Rheumatol, 2013
The most strongly associated pathway concerned HLA: rs1063478 alters the role of HLA-DMA in the context of the pathway of antigen processing and presentation of peptide antigen.
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.
Yamazaki et al., Singapore, Singapore. In Stem Cells, 2012
DNA microarray analysis and immunohistochemistry demonstrated that HLA-DMA was specifically expressed in drug-resistant LGR5(-) cells, and epiregulin was expressed in both LGR5(+) and drug-resistant LGR5(-) cells.
Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock.
Venet et al., In Crit Care, 2012
On the third day after shock, the mRNA expressions of five MHC class II-related genes (CD74, HLA-DRA, HLA-DMB, HLA-DMA, CIITA) were measured by qRT-PCR and monocyte human leukocyte antigen-DR (mHLA-DR) by flow cytometry.
Analysis of HLA-DM polymorphisms in the Chinese Han population.
Liu et al., Shanghai, China. In Tissue Antigens, 2012
DMA*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
Mellins et al., Stanford, United States. In Immunology, 2010
Multiple mechanisms, operating along the biosynthetic pathway of class II molecules, contribute to DM-mediated increases in the abundance of low-CLIP-affinity alleles.
The DMalpha and DMbeta chain cooperate in the oxidation and folding of HLA-DM.
Benham et al., Durham, United Kingdom. In J Immunol, 2006
glycosylation promotes, but is not essential for, DMalphabeta ER exit; single DMalpha chains cannot fully oxidize without DMbeta, while DMbeta forms disulfide-linked homodimers without DMalpha
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.
Neefjes et al., Amsterdam, Netherlands. In Immunity, 2005
The absence of HLA-DR/DM interactions at the limiting membrane prevents local loading of MHC class II molecules in phagosomes
[Association of human leukocyte antigen non-classical genes with type 1 diabetes].
Hu et al., Beijing, China. In Zhonghua Er Ke Za Zhi, 2003
HLA-DMA may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism.
Genetic influences on sarcoidosis.
Ohno et al., Yokohama, Japan. In Eye (lond), 1996
We screened the TNFA, TNFB, HSP70-1 and Hum70t genes around the class III region, as well as the HLA-DMA and -DMB genes in the class II region, for genetic polymorphism in sarcoidosis.
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.
Cresswell et al., New Haven, United States. In Immunity, 1994
The defect is repaired by introducing HLA-DMA and HLA-DMB cDNA expression vectors, determined by the restoration of SDS stability of class II alpha beta dimers, restoration of a normal conformation for HLA-DR3 as detected by a monoclonal antibody, and by a reduction in class II-associated invariant chain peptides.
Antigen presentation. Getting peptides into MHC class II molecules.
Cresswell, New Haven, United States. In Curr Biol, 1994
The long search for MHC-linked genes known to be required for antigen processing has turned up HLA-DMA and HLA-DMB, genes that seem to encode a dimer similar to the MHC class II molecule.
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.
Pious et al., Seattle, United States. In Nature, 1994
We show that (1) mutant 2.2.93 contains a mutation in HLA-DMA, and a representative c2p-1 mutant, 9.5.3,
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