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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Major histocompatibility complex, class I, B

HLA-B, HLA-B27, B-12
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HLA-A, CAN, HAD, AGE, DRB1
Papers using HLA-B antibodies
Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS
Supplier
Ma Averil et al., In Nature immunology, 2009
... Inflammatory disease in HLA-B27 transgenic rats ...
Inhibition of tumor angiogenesis in vivo by monoclonal antibody targeted to domain 5 of high molecular weight kininogen
Supplier
Colman Robert W et al., In Arthritis Research & Therapy, 2003
... HLA-B27 transgenic male rats were purchased ...
Expression of estrogen receptor related protein (p29) and estradiol binding in human arthritic synovium
Supplier
Harnish Douglas C et al., In Arthritis Research & Therapy, 1994
... Male HLA-B27 transgenic rats were obtained from ...
Papers on HLA-B
Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01.
New
Chong et al., Singapore, Singapore. In Photochem Photobiol, Feb 2016
All patients did not have a family history of AP and none had mucosal involvement, as such these clinical features differed from Caucasian AP patients.
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
New
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
The soluble and cellular mediators of these closely related diseases are being elucidated through genetic approaches such as genome-wide association studies (GWAS), as well as animal and molecular models.
Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
New
Lin et al., Taipei, Taiwan. In Scand J Rheumatol, Feb 2016
OBJECTIVES: This phase IIIB study compared the efficacy and safety of febuxostat and allopurinol in gout patients with or without tophi who were HLA-B*5801 negative.
Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis.
New
Orman et al., In Bosn J Basic Med Sci, Feb 2016
Serum calprotectin levels are associated with certain inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.
Gut inflammation and microbiome in spondyloarthritis.
Review
New
Danda et al., Vellore, India. In Rheumatol Int, Jan 2016
Bowel inflammation is common in SpA, which may be classified as acute or chronic.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
New
Ueno et al., Kumamoto, Japan. In Mbio, Dec 2015
However, the effects of HLA polymorphisms on recognition by primary Nef isolates remain elusive, as do the specific Nef regions responsible for downregulation of HLA-A versus HLA-B.
The ongoing quest for biomarkers in Ankylosing Spondylitis.
Review
New
O'Dell et al., Omaha, United States. In Int J Rheum Dis, Nov 2015
The C-reactive protein and HLA-B27 are most commonly used biomarkers.
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.
Review
New
Ueta, Kyoto, Japan. In Cornea, Nov 2015
Cold medicine-related SJS/TEN (CM-SJS/TEN) with SOCs is associated with HLA-A*02:06 in Japanese and Koreans and HLA-B*44:03 in Japanese, Indians, and Brazilian whites.
Genetics of ankylosing spondylitis-insights into pathogenesis.
Review
New
Wordsworth et al., Brisbane, Australia. In Nat Rev Rheumatol, Nov 2015
However, even though many theories have been advanced to explain how HLA-B(*)27 is involved in AS, no consensus about the answers to this question has been reached, and no successful treatments have yet been developed that target HLA-B27 or its functional pathways.
Class II HLA interactions modulate genetic risk for multiple sclerosis.
New
Impact
International Multiple Sclerosis Genetics Consortium et al., In Nat Genet, Oct 2015
Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02.
The involvement of the spine in psoriatic arthritis.
Review
New
Braun et al., Bochum, Germany. In Clin Exp Rheumatol, Sep 2015
In addition, clinical examination of patients initially diagnosed as PsA due to peripheral symptoms and skin lesions may also show inflammation in the axial skeleton causing inflammatory back pain, stiffness and changes on imaging including sacroiliitis, spondylitis and syndesmophyte formation, similar to what is known from ankylosing spondylitis (AS), the prototype of SpA.
Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
New
Impact
Kubo et al., Tokyo, Japan. In Nat Genet, Jul 2015
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
HLA-B27.
Review
Impact
Bowness, Oxford, United Kingdom. In Annu Rev Immunol, 2014
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown.
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Impact
Chanock et al., Rochester, United States. In Nat Genet, 2014
In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively).
HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.
Impact
Maiers et al., Latvia. In N Engl J Med, 2014
However, many patients will not have an optimal adult donor--that is, a donor who is matched at high resolution at HLA-A, HLA-B, HLA-C, and HLA-DRB1.
Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules.
GeneRIF
Sorrentino et al., Roma, Italy. In J Biol Chem, 2012
Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules.
Residue 81 confers a restricted C-terminal peptide binding motif in HLA-B*44:09.
GeneRIF
Bade-Doeding et al., Hannover, Germany. In Immunogenetics, 2012
Data indicate that B*44:09-derived peptides are restricted predominantly to L (Leu) or F (Phe).
HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.
GeneRIF
Xu et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
The relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted cytotoxic T lymphocytes.
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Impact
GeneRIF
Walker et al., Boston, United States. In Nat Immunol, 2012
The data indicated that HLA-B*27- and HLA-B*57-restricted CD8+ T cells targeting the same epitopes in elite controllers and progressors were distinctly different, on the basis of potency and cross-reactivity of TCR recognition of HIV-1 and viral variants.
Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease.
GeneRIF
Petzl-Erler et al., Curitiba, Brazil. In Plos One, 2011
Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease.
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