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Major histocompatibility complex, class I, A

HLA-A, A-I, major histocompatibility complex class I
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HLA-B, CAN, MHC, DRB1, HAD
Papers on HLA-A
A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.
Chen et al., New York City, United States. In Nature, Feb 2016
UNASSIGNED: Cellular immunity against viral infection and tumour cells depends on antigen presentation by major histocompatibility complex class I (MHC I) molecules.
Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.
Spritz et al., Milano, Italy. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: HLA-A is a class I major histocompatibility complex receptor that presents peptide antigens on the surface of most cells.
Prediction of T Cell Epitopes from Leishmania major Potentially Excreted/Secreted Proteins Inducing Granzyme B Production.
Louzir et al., Tunisia. In Plos One, Dec 2015
Seventy-eight nonameric peptides that are predicted to be loaded by HLA-A*0201 molecule were generated and their binding capacity to HLA-A2 was evaluated.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
Ueno et al., Kumamoto, Japan. In Mbio, Dec 2015
UNLABELLED: HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells.
Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies.
Hattori et al., Tokyo, Japan. In Plos One, Dec 2015
The CTLs induced by PEPP2271-279 recognized PEPP2-positive target cells in an HLA-A*24:02-restricted manner.
Etiology and Pathogenesis of Psoriatic Arthritis.
Ritchlin et al., Rochester, United States. In Rheum Dis Clin North Am, Nov 2015
Although specific major histocompatibility complex class I molecules are associated with the psoriatic disease phenotype, no specific antigen or autoantibody has been identified.
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.
Ueta, Kyoto, Japan. In Cornea, Nov 2015
Cold medicine-related SJS/TEN (CM-SJS/TEN) with SOCs is associated with HLA-A*02:06 in Japanese and Koreans and HLA-B*44:03 in Japanese, Indians, and Brazilian whites.
The immunogenetics of Behçet's disease: A comprehensive review.
Remmers et al., Bethesda, United States. In J Autoimmun, Nov 2015
In addition to the positive association of HLA-B*51, which was identified more than four decades ago, and which has since been confirmed in multiple populations, recent studies report additional independent associations in the major histocompatibility complex class I region.
Toward the Clonotype Analysis of Alopecia Areata-Specific, Intralesional Human CD8+ T Lymphocytes.
Paus et al., Münster, Germany. In J Investig Dermatol Symp Proc, Nov 2015
Autoreactive CD8+ T cells are not only present in the characteristic peribulbar inflammatory cell infiltrate of lesional AA HFs but are also found to be infiltrating in lesional HF epithelium where they are thought to recognize major histocompatibility complex class I-presented (auto-)antigens.
Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1.
Scheinberg et al., New York City, United States. In Nat Biotechnol, Oct 2015
Here we describe a bispecific T-cell engager (BiTE) antibody derived from a T-cell receptor (TCR)-mimic monoclonal antibody (mAb) ESK1, which binds a peptide derived from the intracellular oncoprotein WT1 presented on HLA-A*02:01.
The pharmacogenomics of epilepsy.
Perucca et al., Pavia, Italy. In Expert Rev Neurother, Oct 2015
The indication for HLA-A*31:01 testing to identify individuals at risk for skin reactions from carbamazepine, or for CYP2C9 genotyping to identify individuals at risk for serious skin reactions from phenytoin is less compelling.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.
Takahama et al., Tokushima, Japan. In Nat Immunol, Oct 2015
Here we report that TCR responsiveness of mature CD8(+) T cells is fine tuned by their affinity for positively selecting peptides in the thymus and that optimal TCR responsiveness requires positive selection on major histocompatibility complex class I-associated peptides produced by the thymoproteasome, which is specifically expressed in the thymic cortical epithelium.
Class II HLA interactions modulate genetic risk for multiple sclerosis.
International Multiple Sclerosis Genetics Consortium et al., In Nat Genet, Oct 2015
Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02.
Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes.
Getz et al., Boston, United States. In Nat Biotechnol, Oct 2015
We describe a computational pipeline that enables accurate inference of germline alleles of class I HLA-A, B and C genes and subsequent detection of mutations in these genes using the inferred alleles as a reference.
Quantification of anti-sperm antibody and soluble MICA/MICB levels in the serum of infertile people of the Li ethnic group in China.
Yu et al., Changsha, China. In Int J Clin Exp Med, 2014
OBJECTIVE: To investigate the presence of anti-sperm antibodies (AsAb) and the correlation between AsAb positivity and the expression of soluble major histocompatibility complex class I chain-related A and B (sMICA or sMICB) in the sera of infertile people of the Li nationality from Hainan, China.
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes.
Heydel et al., Bucureşti, Romania. In Toxicol Lett, 2012
Catalytic properties/expression of UGT1A6/7 are influenced by the pro-oxidant environment in astrocytes.
HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.
Xu et al., Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
The relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted cytotoxic T lymphocytes.
Generation of donor-specific anti-human leukocyte antigen antibodies after the transplantation of a fully matched kidney allograft and its impact on the selection of a subsequent renal regraft: a case report.
Altermann et al., Halle, Germany. In Transplant Proc, 2012
Case Report: rare HLA-A25 genotype may result in allele-specific antibodies directed against the common variants, thus leading to unexpected positive cross-match results against apparently matched allografts.
[HLA-class I gene polymorphisms in Japanese Stevens-Johnson syndrome patients with ocular surface complications].
Kinoshita et al., Kyoto, Japan. In Nihon Ganka Gakkai Zasshi, 2012
HLA-A* 0206 is strongly associated with Japanese SJS/TEN patients with ocular surface complications.
High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation.
Wistuba et al., Houston, United States. In J Thorac Oncol, 2012
High RFC1 is associated with adenocarcinoma in non-small-cell lung carcinoma EGFR [corrected] mutation.
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