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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hexokinase 3

HK3, Hook3, HK III
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: Hexokinase, hK2, CAN, STEP, Insulin
Papers using HK3 antibodies
Golgi membranes are absorbed into and reemerge from the ER during mitosis
Supplier
Krämer Helmut et al., In The Journal of Cell Biology, 1998
... The full-length human Hook3 sequence was obtained by 5′ and 3′ RACE reactions from a human placental cDNA library (CLONTECH Laboratories, Inc.) ...
Papers on HK3
High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3.
New
Fragoso et al., São Paulo, Brazil. In Acta Radiol, Apr 2015
PURPOSE: To investigate whether there is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH.
Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis.
Wang et al., Harbin, China. In Blood Cells Mol Dis, 2015
For the 75 key genes, 27 disease risk sub-pathways were identified, and HK3, HNMT, SULT2B1, KYNU, and PTGS2 were the significant key genes which were enriched in these sub-pathways.
High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer.
Krech et al., Hamburg, Germany. In Plos One, 2014
Hook microtubule-tethering protein 3 (HOOK3) is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking.
Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
Holzer et al., Leipzig, Germany. In Plos One, 2014
In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes.
Crystal structures of apparent saccharide sensors from histidine kinase receptors prevalent in a human gut symbiont.
Hendrickson et al., New York City, United States. In Febs J, 2014
These sensor domains belong to the third most populated (HK3) family based on a previous unpublished bioinformatics analysis of predicted histidine kinase sensors.
Meta-analysis of loci associated with age at natural menopause in African-American women.
Rajkovic et al., Framingham, United States. In Hum Mol Genet, 2014
We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8.
[Comparison and analysis of SNV results: detected by transcriptome sequencing technology on initial diagnosis and remission stage of a patient with AML-M2].
Liu et al., Changzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
Among them, 11 acquired mutations (P < 0.05) in coding regions were got, including ZRSR1, MLXIP, TLN1, LAP3, HK3.
CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation.
Tschan et al., Bern, Switzerland. In Sci Rep, 2013
In this study, we identified two novel unrelated CEBPA target genes, the glycolytic enzyme hexokinase 3 (HK3) and the krüppel-like factor 5 (KLF5) transcription factor, by comparing gene profiles in two cohorts of CEBPA wild-type and mutant AML patients.
Indocyanine green derivative 02-2-deoxy-d-glucose
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
HKI, HKII, and HKIII have molecular weights of ~100,000 each; HKI is found mainly in the brain, and HKII is insulin-sensitive and is found in adipose and muscle cells.
Cypate-2-Deoxy-d-glucose
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
HKI, HKII, and HKIII have molecular weights of ~100,000 each; HKI is found mainly in the brain, and HKII is insulin-sensitive and is found in adipose and muscle cells.
PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.
GeneRIF
Tschan et al., Bern, Switzerland. In Blood, 2012
HK3 is: (1) directly activated by PU.1, (2) repressed by PML-RARA, and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia cells.
ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure.
Review
Chen et al., Jinan, China. In Orphanet J Rare Dis, 2011
RESULTS: Three SNPs - rs2278493 in HK3, rs2234693 in ESR1 and rs12611091 in BRSK1 - showed nominally significant association with POF.
6-Deoxy-6-[(18)F]fluoro-D-fructose
Review
Leung, Bethesda, United States. In Unknown Journal, 2011
HKI, HKII, and HKIII have molecular weights of ~100,000 each.
Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.
GeneRIF
Tsai et al., Cambridge, United States. In Neuron, 2010
Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1.
Regulation and cytoprotective role of hexokinase III.
GeneRIF
Ardehali et al., Chicago, United States. In Plos One, 2009
Data show that HKIII exerts protective effects against oxidative stress, perhaps by increasing ATP levels, reducing oxidant-induced ROS production, preserving mitochondrial membrane potential, and increasing mitochondrial biogenesis.
Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.
GeneRIF
Van de Wiele et al., Groningen, Netherlands. In Histol Histopathol, 2009
The expression pattern of HK3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.
Impact
Chasman et al., Boston, United States. In Nat Genet, 2009
(in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L).
IRDye800-2-Deoxy-D-glucose
Review
Leung, Bethesda, United States. In Unknown Journal, 2009
HKI, HKII, and HKIII have molecular weights of ~100,000 each; HKI is found mainly in the brain, and HKII is insulin-sensitive and is found in adipose and muscle cells.
Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
GeneRIF
van Diest et al., Amsterdam, Netherlands. In Clin Endocrinol (oxf), 2008
Data demonstrated that in addition to galectin-3, HK III and cyclin A profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography.
Impact
Molthoff et al., Amsterdam, Netherlands. In J Clin Oncol, 2002
HIF-1alpha, VEGF(165), HK II, HK III, and macrophages showed no univariate correlation with (18)FDG.
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